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Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition.
Compher C, Bingham AL, McCall M, Patel J, Rice TW, Braunschweig C, McKeever L. Compher C, et al. JPEN J Parenter Enteral Nutr. 2022 Jan;46(1):12-41. doi: 10.1002/jpen.2267. Epub 2022 Jan 3. JPEN J Parenter Enteral Nutr. 2022. PMID: 34784064
BACKGROUND: This guideline updates recommendations from the 2016 American Society for Parenteral and Enteral Nutrition (ASPEN)/Society of Critical Care Medicine (SCCM) critical care nutrition guideline for five foundational questions central to critical care …
BACKGROUND: This guideline updates recommendations from the 2016 American Society for Parenteral and Enteral Nutrition (ASPEN)/Society of Cr …
An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients.
Limper AH, Knox KS, Sarosi GA, Ampel NM, Bennett JE, Catanzaro A, Davies SF, Dismukes WE, Hage CA, Marr KA, Mody CH, Perfect JR, Stevens DA; American Thoracic Society Fungal Working Group. Limper AH, et al. Am J Respir Crit Care Med. 2011 Jan 1;183(1):96-128. doi: 10.1164/rccm.2008-740ST. Am J Respir Crit Care Med. 2011. PMID: 21193785
At the same time, the introduction of new treatment modalities has significantly broadened options available to physicians who treat these conditions. While traditionally antifungal therapy was limited to the use of amphotericin B, flucytosine, and a handful of clinically …
At the same time, the introduction of new treatment modalities has significantly broadened options available to physicians who treat these c …
Ramatroban for chemoprophylaxis and treatment of COVID-19: David takes on Goliath.
Chiang KC, Rizk JG, Nelson DJ, Krishnamurti L, Subbian S, Imig JD, Khan I, Reddy ST, Gupta A. Chiang KC, et al. Expert Opin Ther Targets. 2022 Jan;26(1):13-28. doi: 10.1080/14728222.2022.2031975. Epub 2022 Feb 22. Expert Opin Ther Targets. 2022. PMID: 35068281 Free PMC article. Review.
INTRODUCTION: In COVID-19 pneumonia, there is a massive increase in fatty acid levels and lipid mediators with a predominance of cyclooxygenase metabolites, notably TxB(2) PGE(2) > PGD(2) in the lungs, and 11-dehydro-TxB(2), a TxA(2) metabolite, in the systemic c …
INTRODUCTION: In COVID-19 pneumonia, there is a massive increase in fatty acid levels and lipid mediators with a predominance …
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?
Bailly C, Vergoten G. Bailly C, et al. Pharmacol Ther. 2020 Oct;214:107618. doi: 10.1016/j.pharmthera.2020.107618. Epub 2020 Jun 24. Pharmacol Ther. 2020. PMID: 32592716 Free PMC article. Review.
At the membrane level, GLR induces cholesterol-dependent disorganization of lipid rafts which are important for the entry of coronavirus into cells. ...
At the membrane level, GLR induces cholesterol-dependent disorganization of lipid rafts which are important for the entry of coronavi …
Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery.
Zhao G, Xue L, Geisler HC, Xu J, Li X, Mitchell MJ, Vaughan AE. Zhao G, et al. Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2314747121. doi: 10.1073/pnas.2314747121. Epub 2024 Feb 5. Proc Natl Acad Sci U S A. 2024. PMID: 38315853 Free PMC article.
However, limited macrophage-specific delivery vehicles have hindered the development of macrophage-targeted therapies. In this study, we screened a pool of 112 lipid nanoparticles (LNPs) to identify an optimal LNP formulation for efficient siRNA delivery. ...
However, limited macrophage-specific delivery vehicles have hindered the development of macrophage-targeted therapies. In this study, …
Drug-induced disorders of glucose metabolism. Mechanisms and management.
Chan JC, Cockram CS, Critchley JA. Chan JC, et al. Drug Saf. 1996 Aug;15(2):135-57. doi: 10.2165/00002018-199615020-00005. Drug Saf. 1996. PMID: 8884164 Review.
On the other hand, the potential hypoglycaemic effects of ACE inhibitors, alpha-blockers, lipid-lowering agents and recombinant human insulin-like growth factor demonstrated in experimental settings, are of potential therapeutic interest. ...An understanding of thes …
On the other hand, the potential hypoglycaemic effects of ACE inhibitors, alpha-blockers, lipid-lowering agents and recombinant human …
Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach.
Baralić K, Jorgovanović D, Živančević K, Antonijević Miljaković E, Antonijević B, Buha Djordjevic A, Ćurčić M, Đukić-Ćosić D. Baralić K, et al. Toxicol Appl Pharmacol. 2020 Nov 1;406:115237. doi: 10.1016/j.taap.2020.115237. Epub 2020 Sep 11. Toxicol Appl Pharmacol. 2020. PMID: 32920000 Free PMC article.
As expected, inflammation, cardiotoxicity, and dyslipidaemias were revealed as the main risks of lopinavir/ritonavir treatment, while chloroquine/hydroxychloroquine + azithromycin therapy was additionally linked to gastrointestinal and skin diseases. According to our resul …
As expected, inflammation, cardiotoxicity, and dyslipidaemias were revealed as the main risks of lopinavir/ritonavir treatment, while chloro …
Top 20 Research Studies of 2019 for Primary Care Physicians.
Ebell MH, Grad R. Ebell MH, et al. Am Fam Physician. 2020 May 15;101(10):608-617. Am Fam Physician. 2020. PMID: 32412223 Free article. Review.
Automated devices are the best way to measure blood pressure. Nonfasting lipid profiles are preferred over fasting lipid profiles, and nonfasting and fasting lipid profiles are equally effective at predicting risk. ...Regarding infections, a meta-analysis sho …
Automated devices are the best way to measure blood pressure. Nonfasting lipid profiles are preferred over fasting lipid profi …
Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK.
Iqbal Z, Ho JH, Adam S, France M, Syed A, Neely D, Rees A, Khatib R, Cegla J, Byrne C, Qureshi N, Capps N, Ferns G, Payne J, Schofield J, Nicholson K, Datta D, Pottle A, Halcox J, Krentz A, Durrington P, Soran H; Heart UK's Medical Scientific and Research Committee. Iqbal Z, et al. Atherosclerosis. 2020 Nov;313:126-136. doi: 10.1016/j.atherosclerosis.2020.09.008. Epub 2020 Sep 15. Atherosclerosis. 2020. PMID: 33045618 Free PMC article. Review.
Some have suggested they may exacerbate their condition. It is important to consider known interactions with lipid-lowering agents and with specific therapies for COVID-19. This statement aims to collate current evidence surrounding the safety of lipid-loweri …
Some have suggested they may exacerbate their condition. It is important to consider known interactions with lipid-lowering agents an …
Systematic Network and Meta-analysis on the Antiviral Mechanisms of Probiotics: A Preventive and Treatment Strategy to Mitigate SARS-CoV-2 Infection.
Patra S, Saxena S, Sahu N, Pradhan B, Roychowdhury A. Patra S, et al. Probiotics Antimicrob Proteins. 2021 Aug;13(4):1138-1156. doi: 10.1007/s12602-021-09748-w. Epub 2021 Feb 3. Probiotics Antimicrob Proteins. 2021. PMID: 33537958 Free PMC article.
The functional modules and pathway enrichment analysis of the association network clearly show that the application of probiotics could have therapeutic effects on ACE2-mediated virus entry, activation of the systemic immune response, nlrp3-mediated immunomodulatory pathwa …
The functional modules and pathway enrichment analysis of the association network clearly show that the application of probiotics could have …
30 results