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Neuromyelitis optica spectrum disorder: Pathogenesis, treatment, and experimental models.
Wu Y, Zhong L, Geng J. Wu Y, et al. Mult Scler Relat Disord. 2019 Jan;27:412-418. doi: 10.1016/j.msard.2018.12.002. Epub 2018 Dec 3. Mult Scler Relat Disord. 2019. PMID: 30530071 Review.
Neuromyelitis optica (NMO) and NMO spectrum disorder (NMOSD) are inflammatory CNS syndromes mainly involving the optic nerve and/or spinal cord and characterized by the presence of serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). The pa …
Neuromyelitis optica (NMO) and NMO spectrum disorder (NMOSD) are inflammatory CNS syndromes mainly involving the …
Treatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study.
Demuth S, Guillaume M, Bourre B, Ciron J, Zephir H, Sirejacob Y, Kerbrat A, Lebrun-Frenay C, Papeix C, Michel L, Laplaud D, Vukusic S, Maillart E, Cohen M, Audoin B, Marignier R, Collongues N; NOMADMUS Study Group. Demuth S, et al. J Neuroinflammation. 2022 Mar 2;19(1):62. doi: 10.1186/s12974-022-02420-2. J Neuroinflammation. 2022. PMID: 35236386 Free PMC article.
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) attacks require an urgent probabilistic anti-inflammatory therapeutic strategy. ...RESULTS: We included 211 attacks among 183 patients (104 with anti-AQP4 antibodies, 60 with a …
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) attacks require an urgent probabilistic anti-inflamma …
Pathogenesis, Clinical Features, and Treatment of Patients with Myelin Oligodendrocyte Glycoprotein (MOG) Autoantibody-Associated Disorders Focusing on Optic Neuritis with Consideration of Autoantibody-Binding Sites: A Review.
Tanaka K, Kezuka T, Ishikawa H, Tanaka M, Sakimura K, Abe M, Kawamura M. Tanaka K, et al. Int J Mol Sci. 2023 Aug 29;24(17):13368. doi: 10.3390/ijms241713368. Int J Mol Sci. 2023. PMID: 37686172 Free PMC article. Review.
Although there is a substantial amount of data on the clinical characteristics, diagnostic criteria, and pathogenesis of myelin oligodendrocyte glycoprotein (MOG) autoantibody-associated disease (MOGAD), there is still uncertainty regarding the MOG protein function and the pathog …
Although there is a substantial amount of data on the clinical characteristics, diagnostic criteria, and pathogenesis of myelin oligodendroc …
Clinical utility of anti-MOG antibody testing in a Danish cohort.
Papp V, Langkilde AR, Blinkenberg M, Schreiber K, Jensen PEH, Sellebjerg F. Papp V, et al. Mult Scler Relat Disord. 2018 Nov;26:61-67. doi: 10.1016/j.msard.2018.09.010. Epub 2018 Sep 11. Mult Scler Relat Disord. 2018. PMID: 30227311
METHODS: In a cross-sectional study 184 adults (age 16) were tested for anti-MOG antibody (Ab) with a cell-based assay. To define the relevant target population for anti-MOG antibody testing in a neurology clinic, we divided the entire st …
METHODS: In a cross-sectional study 184 adults (age 16) were tested for anti-MOG antibody (Ab) with a cell-based assay. …
Identifying autoantigens in demyelinating diseases: valuable clues to diagnosis and treatment?
Derfuss T, Meinl E. Derfuss T, et al. Curr Opin Neurol. 2012 Jun;25(3):231-8. doi: 10.1097/WCO.0b013e3283533a64. Curr Opin Neurol. 2012. PMID: 22487571 Review.
Patients with anti-AQP4 have the distinct clinical presentation of neuromyelitis optica (NMO), and these patients often also harbour other autoimmune responses. In contrast, anti-MOG is seen in patients with different disease entities such as childhood …
Patients with anti-AQP4 have the distinct clinical presentation of neuromyelitis optica (NMO), and these patients often also h …
Successful treatment of a woman with relapsing neuromyelitis optica by interferon beta.
Xu Y, Zhang Y, Ye J, Peng B, Wang JM, Cui LY. Xu Y, et al. Neurol Sci. 2012 Aug;33(4):911-3. doi: 10.1007/s10072-011-0849-0. Epub 2011 Nov 27. Neurol Sci. 2012. PMID: 22120187
Neuromyelitis optica (NMO) is an antibody-mediated disease with the target antigen being the water channel aquaporin-4 (AQP4). ...However, we present a case of NMO with positive anti-myelin oligodendrocyte glycoprotein (MOG)(27-38) IgG and anti-AQP4 IgG treat …
Neuromyelitis optica (NMO) is an antibody-mediated disease with the target antigen being the water channel aquaporin-4 …
An update on epidemiology, diagnosis & management of NMO-SD in the tertiary neurology department of Marrakech (Morocco).
Kissani N, Cherkaoui Rhazouani O, Berrhoute L, Chraa M, Louhab N. Kissani N, et al. Rev Neurol (Paris). 2021 Jan-Feb;177(1-2):80-84. doi: 10.1016/j.neurol.2020.05.006. Epub 2020 Jul 30. Rev Neurol (Paris). 2021. PMID: 32741562
INTRODUCTION: Neuromyelitis optica (NMO) and NMO spectrum disorders (NMO-SD) are inflammatory demyelinating diseases of the central nervous system. ...Cervical myelitis extending to more than three vertebrae was found in 60% of patients. AQP4-antibody …
INTRODUCTION: Neuromyelitis optica (NMO) and NMO spectrum disorders (NMO-SD) are inflammatory demyelinating diseases of …
Comparing myelin oligodendrocyte glycoprotein antibody (MOG-Ab) and non MOG-Ab associated optic neuritis: Clinical course and treatment outcome.
Etemadifar M, Abbasi M, Salari M, Etemadifar F, Tavakoli H. Etemadifar M, et al. Mult Scler Relat Disord. 2019 Jan;27:127-130. doi: 10.1016/j.msard.2018.10.013. Epub 2018 Oct 19. Mult Scler Relat Disord. 2019. PMID: 30368225
BACKGROUND: Recent studies have suggested that anti-MOG antibodies and optic neuritis are associated and anti-MOG antibody positive patients have had better recoveries. ...METHODS: Patients diagnosed with optic neuritis were referred for …
BACKGROUND: Recent studies have suggested that anti-MOG antibodies and optic neuritis are associated and anti- …
Paediatric acute disseminated encephalomyelitis followed by optic neuritis: disease course, treatment response and outcome.
Wong YYM, Hacohen Y, Armangue T, Wassmer E, Verhelst H, Hemingway C, van Pelt ED, Catsman-Berrevoets CE, Hintzen RQ, Deiva K, Lim MJ, Rostásy K, Neuteboom RF. Wong YYM, et al. Eur J Neurol. 2018 May;25(5):782-786. doi: 10.1111/ene.13602. Epub 2018 Mar 9. Eur J Neurol. 2018. PMID: 29443442
BACKGROUND AND PURPOSE: Acute disseminated encephalomyelitis followed by optic neuritis (ADEM-ON) is a rare demyelinating syndrome that is different from multiple sclerosis and neuromyelitis optica spectrum disorder. The aim of this study was to descri …
BACKGROUND AND PURPOSE: Acute disseminated encephalomyelitis followed by optic neuritis (ADEM-ON) is a rare demyelinating syndrome that is d …