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beta-Casein nanoparticle-based oral drug delivery system for potential treatment of gastric carcinoma: stability, target-activated release and cytotoxicity.
Shapira A, Davidson I, Avni N, Assaraf YG, Livney YD. Shapira A, et al. Eur J Pharm Biopharm. 2012 Feb;80(2):298-305. doi: 10.1016/j.ejpb.2011.10.022. Epub 2011 Nov 9. Eur J Pharm Biopharm. 2012. PMID: 22085654
Following encapsulation and simulated digestion with pepsin (2 hours at pH=2, 37 C), paclitaxel retained its cytotoxic activity to human N-87 gastric cancer cells; the IC(50) value (32.5 6.2 nM) was similar to that of non-encapsulated paclitaxel (25.4 2.6 nM). Witho …
Following encapsulation and simulated digestion with pepsin (2 hours at pH=2, 37 C), paclitaxel retained its cytotoxic activity to human N-8 …
Liposomal daunorubicin as treatment for Kaposi's sarcoma.
Petre CE, Dittmer DP. Petre CE, et al. Int J Nanomedicine. 2007;2(3):277-88. Int J Nanomedicine. 2007. PMID: 18019828 Free PMC article. Review.
As a result, KS patients benefit from higher cumulative chemotherapeutic doses without significant cardiotoxicity. Tumor response to DNX treatment surpasses that of non-encapsulated daunorubicin and is similar to that observed with conventional multi-drug therapi
As a result, KS patients benefit from higher cumulative chemotherapeutic doses without significant cardiotoxicity. Tumor response to DNX tre …
Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer.
Xu J, Singh A, Amiji MM. Xu J, et al. BMC Cancer. 2014 Feb 8;14:75. doi: 10.1186/1471-2407-14-75. BMC Cancer. 2014. PMID: 24507760 Free PMC article.
BACKGROUND: Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing frontline chemotherapeutic drugs. Gene therapy in combination with a cytotoxic agent could be a promising approach to circumvent the limi …
BACKGROUND: Pancreatic adenocarcinoma is one of the most dreaded cancers with very low survival rate and poor prognosis to the existing fron …
Postenucleation orbital radiotherapy for the treatment of malignant melanoma of the choroid with extrascleral extension.
Hykin PG, McCartney AC, Plowman PN, Hungerford JL. Hykin PG, et al. Br J Ophthalmol. 1990 Jan;74(1):36-9. doi: 10.1136/bjo.74.1.36. Br J Ophthalmol. 1990. PMID: 2106340 Free PMC article.
The outcome is reported in 17 patients in whom an eye was enucleated for malignant melanoma of the choroid with extrascleral extension and who subsequently underwent adjuvant external beam radiotherapy to the orbit as the primary treatment of the extraocular spread of their tumou …
The outcome is reported in 17 patients in whom an eye was enucleated for malignant melanoma of the choroid with extrascleral extension and w …