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Page 1
Clinical Efficacy and Short-Term Prognosis of Butylphthalide and Sodium Chloride Injection Compared to Edaravone in the Treatment of Patients with Acute Stroke.
Yang D, Zhang M, Wang X, Zhang J. Yang D, et al. Altern Ther Health Med. 2023 Oct;29(7):370-375. Altern Ther Health Med. 2023. PMID: 37499159 Free article. Review.
On the other hand, edaravone demonstrated its efficacy by reducing oxidative stress response, inhibiting inflammatory response, and regulating the metabolism of arachidonic acid and apoptosis. These findings highlight the distinct mechanisms through which but …
On the other hand, edaravone demonstrated its efficacy by reducing oxidative stress response, inhibiting inflammatory response …
Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications.
Anderson G, Maes M. Anderson G, et al. Curr Top Med Chem. 2020;20(7):524-539. doi: 10.2174/1568026620666200131094445. Curr Top Med Chem. 2020. PMID: 32003689 Review.
Both orexin and melatonin positively regulate mitochondria oxidative phosphorylation. Consequently, gut-mediated increases in ceramide have impacts on the circadian rhythm and the circadian regulation of mitochondrial function. Butyrate, orexin and mel …
Both orexin and melatonin positively regulate mitochondria oxidative phosphorylation. Consequently, gut-mediated increa …
Targeting the Canonical WNT/beta-Catenin Pathway in Cancer Treatment Using Non-Steroidal Anti-Inflammatory Drugs.
Vallée A, Lecarpentier Y, Vallée JN. Vallée A, et al. Cells. 2019 Jul 15;8(7):726. doi: 10.3390/cells8070726. Cells. 2019. PMID: 31311204 Free PMC article. Review.
Chronic inflammation and oxidative stress are common and co-substantial pathological processes accompanying and contributing to cancers. ...This pathway is closely associated with both chronic inflammation and oxidative stress in cancers. The ad …
Chronic inflammation and oxidative stress are common and co-substantial pathological processes accompanying and contrib …
Redox-dependent regulation of the Na+-K+ pump: new twists to an old target for treatment of heart failure.
Liu CC, Fry NA, Hamilton EJ, Chia KK, Garcia A, Karimi Galougahi K, Figtree GA, Clarke RJ, Bundgaard H, Rasmussen HH. Liu CC, et al. J Mol Cell Cardiol. 2013 Aug;61:94-101. doi: 10.1016/j.yjmcc.2013.05.013. Epub 2013 May 30. J Mol Cell Cardiol. 2013. PMID: 23727392 Free article. Review.
Its role as a target is well integrated with the paradigms of neurohormonal abnormalities, raised myocardial oxidative stress and energy deficiency implicated in the pathophysiology of the failing heart. ...This article is part of a Special Issue entitled "Na(+)R …
Its role as a target is well integrated with the paradigms of neurohormonal abnormalities, raised myocardial oxidative stress …
Glucocorticosteroids as antioxidants in treatment of asthma and COPD. New application for an old medication?
Sadowska AM, Klebe B, Germonpré P, De Backer WA. Sadowska AM, et al. Steroids. 2007 Jan;72(1):1-6. doi: 10.1016/j.steroids.2006.10.007. Epub 2006 Dec 4. Steroids. 2007. PMID: 17145070 Review.
Inhaled corticosteroids (ICS) are the standard of care in asthma and are widely used in the treatment of patients with COPD. ...Inflammatory processes are usually accompanied by an increased oxidative burden followed by a depletion of antioxidants. ...
Inhaled corticosteroids (ICS) are the standard of care in asthma and are widely used in the treatment of patients with COPD. ...Infla …
Exploring the mechanism of Buyang Huanwu Decoction in the treatment of spinal cord injury based on network pharmacology and molecular docking.
Wang Y, Chen H, Wang J, Chen X, Chen L. Wang Y, et al. Medicine (Baltimore). 2022 Oct 7;101(40):e31023. doi: 10.1097/MD.0000000000031023. Medicine (Baltimore). 2022. PMID: 36221378 Free PMC article.
By studying protein-protein interaction network, a total of 8 core proteins were identified, primarily interleukin-6, tumor protein P53, epidermal growth factor receptor, and others. Positive regulation of kinase activity regulation of reaction to inorganic c …
By studying protein-protein interaction network, a total of 8 core proteins were identified, primarily interleukin-6, tumor protein P53, epi …
Mitochondria dysfunction in CD8+ T cells as an important contributing factor for cancer development and a potential target for cancer treatment: a review.
Zhang L, Zhang W, Li Z, Lin S, Zheng T, Hao B, Hou Y, Zhang Y, Wang K, Qin C, Yue L, Jin J, Li M, Fan L. Zhang L, et al. J Exp Clin Cancer Res. 2022 Jul 21;41(1):227. doi: 10.1186/s13046-022-02439-6. J Exp Clin Cancer Res. 2022. PMID: 35864520 Free PMC article. Review.
Excessively low mitochondrial membrane potential will cause the release of cytochrome c and apoptosis of CD8+ T cells, while excessively high will exacerbate oxidative stress. Dysregulation of mitochondrial Ca2+ signaling will affect various physiological pathways i …
Excessively low mitochondrial membrane potential will cause the release of cytochrome c and apoptosis of CD8+ T cells, while excessively hig …
Thermosensitive hydrogel with emodin-loaded triple-targeted nanoparticles for a rectal drug delivery system in the treatment of chronic non-bacterial prostatitis.
Ye Y, Zhong W, Luo R, Wen H, Ma Z, Qi S, Han X, Nie W, Chang D, Xu R, Ye N, Gao F, Zhang P. Ye Y, et al. J Nanobiotechnology. 2024 Jan 18;22(1):33. doi: 10.1186/s12951-023-02282-7. J Nanobiotechnology. 2024. PMID: 38238760 Free PMC article.
Thus, we developed a triple-targeted nanoparticle (NPs)/thermosensitive hydrogel (Gel) rectal drug delivery system. In this process, LF, with its positive charge, was utilized to load EMO through dialysis, producing LF@EMO-NPs. ...Animal experiments showed that rect …
Thus, we developed a triple-targeted nanoparticle (NPs)/thermosensitive hydrogel (Gel) rectal drug delivery system. In this process, …
A New Treatment Strategy for Parkinson's Disease through the Gut-Brain Axis: The Glucagon-Like Peptide-1 Receptor Pathway.
Kim DS, Choi HI, Wang Y, Luo Y, Hoffer BJ, Greig NH. Kim DS, et al. Cell Transplant. 2017 Sep;26(9):1560-1571. doi: 10.1177/0963689717721234. Cell Transplant. 2017. PMID: 29113464 Free PMC article. Review.
Common pathophysiological features exist between T2DM, AD, and PD, including oxidative stress, inflammation, insulin resistance, abnormal protein processing, and cognitive decline, and suggest that effective drugs for T2DM that positively impact the gu …
Common pathophysiological features exist between T2DM, AD, and PD, including oxidative stress, inflammation, insulin resistanc …
The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways.
Guerram M, Jiang ZZ, Yousef BA, Hamdi AM, Hassan HM, Yuan ZQ, Luo HW, Zhu X, Zhang LY. Guerram M, et al. Oncotarget. 2015 Sep 8;6(26):21865-77. doi: 10.18632/oncotarget.4156. Oncotarget. 2015. PMID: 26068969 Free PMC article.
However, the molecular mechanism(s) mediating this cytotoxic effect on HER2-positive breast cancer remained undefined. Studies described here report that ATA induced G1/S phase arrest and apoptosis in the HER2-positive MDA-MB-453, SK-BR-3, and BT-474 breast cancer c …
However, the molecular mechanism(s) mediating this cytotoxic effect on HER2-positive breast cancer remained undefined. Studies descri …