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The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.
Van de Wijer L, van der Heijden WA, Ter Horst R, Jaeger M, Trypsteen W, Rutsaert S, van Cranenbroek B, van Rijssen E, Joosten I, Joosten L, Vandekerckhove L, Schoofs T, van Lunzen J, Netea MG, Koenen HJPM, van der Ven AJAM, de Mast Q. Van de Wijer L, et al. Front Immunol. 2021 Apr 19;12:661990. doi: 10.3389/fimmu.2021.661990. eCollection 2021. Front Immunol. 2021. PMID: 33953724 Free PMC article.
Long-term changes in the immune system of successfully treated people living with HIV (PLHIV) remain incompletely understood. In this study, we assessed 108 white blood cell (WBC) populations in a cohort of 211 PLHIV on stable antiretroviral therapy and in 56 HIV-un …
Long-term changes in the immune system of successfully treated people living with HIV (PLHIV) remain incompletely understood. In this study, …
Direct-Acting Antiviral Treatment of HCV Infection Does Not Resolve the Dysfunction of Circulating CD8(+) T-Cells in Advanced Liver Disease.
Vranjkovic A, Deonarine F, Kaka S, Angel JB, Cooper CL, Crawley AM. Vranjkovic A, et al. Front Immunol. 2019 Aug 13;10:1926. doi: 10.3389/fimmu.2019.01926. eCollection 2019. Front Immunol. 2019. PMID: 31456810 Free PMC article.
In HCV(+)(F4) individuals, nearly all CD8(+) T-cell subsets had an elevated proportion of perforin(+) cells while naive cells had increased proportions of IFN-gamma(+) and CD107(+) cells. These exaggerated CD8(+) T-cell activities were not resolved when evaluated 24 weeks …
In HCV(+)(F4) individuals, nearly all CD8(+) T-cell subsets had an elevated proportion of perforin(+) cells while naive cells had increased …
Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria.
Looareesuwan S, Sjostrom L, Krudsood S, Wilairatana P, Porter RS, Hills F, Warrell DA. Looareesuwan S, et al. Am J Trop Med Hyg. 1999 Jul;61(1):26-33. doi: 10.4269/ajtmh.1999.61.26. Am J Trop Med Hyg. 1999. PMID: 10432050
On admission all patients had markedly elevated levels of TNF-alpha (85-1,532 ng/L) and interleukin-6 (IL-6) (30-27,500 ng/L). Also, 86% had elevated interferon-gamma (IFN-gamma) levels, 75% had increased IL-2 levels, 36% had increased IL-8 levels, and 21% ha …
On admission all patients had markedly elevated levels of TNF-alpha (85-1,532 ng/L) and interleukin-6 (IL-6) (30-27,500 ng/L). Also, 86% had …