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Treatment of Richter's syndrome.
Thompson PA, Siddiqi T. Thompson PA, et al. Hematology Am Soc Hematol Educ Program. 2022 Dec 9;2022(1):329-336. doi: 10.1182/hematology.2022000345. Hematology Am Soc Hematol Educ Program. 2022. PMID: 36485138 Free PMC article. Review.
Richter's syndrome (RS) is an aggressive histologic transformation of chronic lymphocytic leukemia (CLL), most commonly to diffuse large B-cell lymphoma (DLBCL). ...Finally, we review available data for bispecific antibodies, antibody-drug conjugates, and chimeric antigen …
Richter's syndrome (RS) is an aggressive histologic transformation of chronic lymphocytic leukemia (CLL), most commonly to diffuse la …
Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment.
Siddiqi OK, Ruberg FL. Siddiqi OK, et al. Trends Cardiovasc Med. 2018 Jan;28(1):10-21. doi: 10.1016/j.tcm.2017.07.004. Epub 2017 Jul 13. Trends Cardiovasc Med. 2018. PMID: 28739313 Free PMC article. Review.
Wild-type ATTR amyloidosis mainly involves the heart, although the reported occurrence of bilateral carpal tunnel syndrome, spinal stenosis and biceps tendon rupture in these patients speaks to more generalized protein deposition. ...Cardiac transplantation can be consider …
Wild-type ATTR amyloidosis mainly involves the heart, although the reported occurrence of bilateral carpal tunnel syndrome, spinal st …
Fixed-duration ibrutinib plus venetoclax for first-line treatment of CLL: primary analysis of the CAPTIVATE FD cohort.
Tam CS, Allan JN, Siddiqi T, Kipps TJ, Jacobs R, Opat S, Barr PM, Tedeschi A, Trentin L, Bannerji R, Jackson S, Kuss BJ, Moreno C, Szafer-Glusman E, Russell K, Zhou C, Ninomoto J, Dean JP, Wierda WG, Ghia P. Tam CS, et al. Blood. 2022 Jun 2;139(22):3278-3289. doi: 10.1182/blood.2021014488. Blood. 2022. PMID: 35196370 Free PMC article.
At baseline, 21% of patients were in the high tumor burden category for tumor lysis syndrome (TLS) risk; after ibrutinib lead-in, only 1% remained in this category. ...
At baseline, 21% of patients were in the high tumor burden category for tumor lysis syndrome (TLS) risk; after ibrutinib lead-in, onl …
Real-World Evidence of Axicabtagene Ciloleucel for the Treatment of Large B Cell Lymphoma in the United States.
Jacobson CA, Locke FL, Ma L, Asubonteng J, Hu ZH, Siddiqi T, Ahmed S, Ghobadi A, Miklos DB, Lin Y, Perales MA, Lunning MA, Herr MM, Hill BT, Ganguly S, Dong H, Nikiforow S, Hooper M, Kawashima J, Xu H, Pasquini MC. Jacobson CA, et al. Transplant Cell Ther. 2022 Sep;28(9):581.e1-581.e8. doi: 10.1016/j.jtct.2022.05.026. Epub 2022 May 21. Transplant Cell Ther. 2022. PMID: 35609867 Free PMC article.
Axicabtagene ciloleucel (axi-cel) is a standard-of-care for patients with relapsed or refractory (r/r) large B cell lymphoma who have received 2 or more lines of prior therapy. ...Patients age 65 years had favorable ORR (odds ratio [OR], 1.39; 95% CI, 1.05 to 1.83) …
Axicabtagene ciloleucel (axi-cel) is a standard-of-care for patients with relapsed or refractory (r/r) large B cell lymphoma who have …
Consensus Clinical Guidance for Diagnosis and Management of Adult COVID-19 Encephalopathy Patients.
Michael BD, Walton D, Westenberg E, García-Azorín D, Singh B, Tamborska AA, Netravathi M, Chomba M, Wood GK, Easton A, Siddiqi OK, Jackson TA, Pollak TA, Nicholson TR, Nair S, Breen G, Prasad K, Thakur KT, Chou SH, Schmutzhard E, Frontera JA, Helbok R, Padovani A, Menon DK, Solomon T, Winkler AS; Global COVID-19 Neuro Research Coalition. Michael BD, et al. J Neuropsychiatry Clin Neurosci. 2023 Winter;35(1):12-27. doi: 10.1176/appi.neuropsych.22010002. Epub 2022 Jul 25. J Neuropsychiatry Clin Neurosci. 2023. PMID: 35872617 Review.
Given the large number of patients hospitalized with severe acute respiratory syndrome coronavirus-2 infection, even these relatively unlikely complications are increasingly recognized and are particularly important because they require specific management. ...
Given the large number of patients hospitalized with severe acute respiratory syndrome coronavirus-2 infection, even these relatively …
Canadian Guidelines for Hereditary Transthyretin Amyloidosis Polyneuropathy Management.
Alcantara M, Mezei MM, Baker SK, Breiner A, Dhawan P, Fiander A, Fine NM, Hahn C, Katzberg HD, Khayambashi S, Massie R, Matte G, Putko B, Siddiqi Z, Delgado D, Bril V. Alcantara M, et al. Can J Neurol Sci. 2022 Jan;49(1):7-18. doi: 10.1017/cjn.2021.34. Epub 2021 Feb 26. Can J Neurol Sci. 2022. PMID: 33631091 Review.
Common neurologic manifestations include: sensorimotor polyneuropathy (PN), autonomic neuropathy, small-fiber PN, and carpal tunnel syndrome. Many patients have significant progression due to diagnostic delays as hATTR PN is not considered within the differential diagnosis …
Common neurologic manifestations include: sensorimotor polyneuropathy (PN), autonomic neuropathy, small-fiber PN, and carpal tunnel syndr …
Tethered cord syndrome: overview of diagnosis and treatment.
Yamada S, Won DJ, Siddiqi J, Yamada SM. Yamada S, et al. Neurol Res. 2004 Oct;26(7):719-21. doi: 10.1179/016164104225017947. Neurol Res. 2004. PMID: 15494110 Review.
This article covers the basis of tethered cord syndrome as a stretch-induced spinal cord disorder, including pathophysiology, signs and symptoms, imaging diagnosis, indication for surgical treatment, and surgical procedures. ...
This article covers the basis of tethered cord syndrome as a stretch-induced spinal cord disorder, including pathophysiology, signs a …
Sleep disorders in chronic obstructive pulmonary disease: etiology, impact, and management.
Budhiraja R, Siddiqi TA, Quan SF. Budhiraja R, et al. J Clin Sleep Med. 2015 Mar 15;11(3):259-70. doi: 10.5664/jcsm.4540. J Clin Sleep Med. 2015. PMID: 25700872 Free PMC article. Review.
Recognition of hypoventilation can be vital as supplemental oxygen therapy itself can acutely worsen hypoventilation and lead to disastrous consequences. Finally, accruing data establish an association between restless leg syndrome and COPD--an association that may …
Recognition of hypoventilation can be vital as supplemental oxygen therapy itself can acutely worsen hypoventilation and lead to disa …
CD19-directed CAR T-cell therapy for treatment of primary CNS lymphoma.
Siddiqi T, Wang X, Blanchard MS, Wagner JR, Popplewell LL, Budde LE, Stiller TL, Clark MC, Lim L, Vyas V, Brown CE, Forman SJ. Siddiqi T, et al. Blood Adv. 2021 Oct 26;5(20):4059-4063. doi: 10.1182/bloodadvances.2020004106. Blood Adv. 2021. PMID: 34492703 Free PMC article.
CD19-directed chimeric antigen receptor (CD19CAR) T-cell therapy has been successful in treating several B-cell lineage malignancies, including B-cell non-Hodgkin lymphoma (NHL). ...Here, we report the outcome of a subset of patients with primary CNS lymphoma (PCNSL; n = 5 …
CD19-directed chimeric antigen receptor (CD19CAR) T-cell therapy has been successful in treating several B-cell lineage malignancies, …
Management of the insulin-dependent diabetic during labor and delivery. Influences on neonatal outcome.
Miodovnik M, Mimouni F, Tsang RC, Skillman C, Siddiqi TA, Butler JB, Holroyde J. Miodovnik M, et al. Am J Perinatol. 1987 Apr;4(2):106-14. doi: 10.1055/s-2007-999750. Am J Perinatol. 1987. PMID: 3551973
Infants of insulin-dependent diabetic mothers are at risk for neonatal polycythemia, hyperbilirubinemia, respiratory distress syndrome (RDS), and hypoglycemia. The purpose of this study was to determine whether labor and delivery management of diabetes may influence the ra …
Infants of insulin-dependent diabetic mothers are at risk for neonatal polycythemia, hyperbilirubinemia, respiratory distress syndrome …
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