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Microcytic anemia. Differential diagnosis and management of iron deficiency anemia.
Massey AC. Massey AC. Med Clin North Am. 1992 May;76(3):549-66. doi: 10.1016/s0025-7125(16)30339-x. Med Clin North Am. 1992. PMID: 1578956 Review.
Microcytic anemia is defined as the presence of small, often hypochromic, red blood cells in a peripheral blood smear and is usually characterized by a low MCV (less than 83 micron 3). Iron deficiency is the most common cause of microcytic anemia. The absence …
Microcytic anemia is defined as the presence of small, often hypochromic, red blood cells in a peripheral blood smear and is usually …
Ineffective erythropoiesis and its treatment.
Cazzola M. Cazzola M. Blood. 2022 Apr 21;139(16):2460-2470. doi: 10.1182/blood.2021011045. Blood. 2022. PMID: 34932791 Free article.
The erythroid marrow and circulating red blood cells (RBCs) are the key components of the human erythron. Abnormalities of the erythron that are responsible for anemia can be separated into 3 major categories: erythroid hypoproliferation, ineffective erythropoiesis, …
The erythroid marrow and circulating red blood cells (RBCs) are the key components of the human erythron. Abnormalities of the erythron that …
Myelodysplastic syndromes with ring sideroblasts (MDS-RS) and MDS/myeloproliferative neoplasm with RS and thrombocytosis (MDS/MPN-RS-T) - "2021 update on diagnosis, risk-stratification, and management".
Patnaik MM, Tefferi A. Patnaik MM, et al. Am J Hematol. 2021 Mar 1;96(3):379-394. doi: 10.1002/ajh.26090. Epub 2021 Jan 28. Am J Hematol. 2021. PMID: 33428785 Free article. Review.
Both diseases are associated with a low risk of leukemic transformation. TREATMENT: Anemia and iron overload are complications seen in both and are managed similar to lower risk MDS and MPN. Luspatercept, a first-in-class erythroid maturation agent is now approved for the …
Both diseases are associated with a low risk of leukemic transformation. TREATMENT: Anemia and iron overload are complications seen i …
Thalidomide as an Effective Treatment in Sideroblastic Anemia, Immunodeficiency, Periodic Fevers, and Developmental Delay (SIFD).
Li Y, Deng M, Han T, Mo W, Mao H. Li Y, et al. J Clin Immunol. 2023 May;43(4):780-793. doi: 10.1007/s10875-023-01441-7. Epub 2023 Feb 2. J Clin Immunol. 2023. PMID: 36729249 Free PMC article.
PURPOSE: Sideroblastic anemia, immunodeficiency, periodic fevers, and developmental delay (SIFD) is an autosomal recessive syndrome caused by biallelic loss-of-function variant of tRNA nucleotidyl transferase 1 (TRNT1). ...The male: female ratio was 1: 1, and the me …
PURPOSE: Sideroblastic anemia, immunodeficiency, periodic fevers, and developmental delay (SIFD) is an autosomal recessive syn …
Erythropoiesis-stimulating agents in the treatment of anemia in myelodysplastic syndromes: a meta-analysis.
Moyo V, Lefebvre P, Duh MS, Yektashenas B, Mundle S. Moyo V, et al. Ann Hematol. 2008 Jul;87(7):527-36. doi: 10.1007/s00277-008-0450-7. Epub 2008 Mar 20. Ann Hematol. 2008. PMID: 18351340 Review.
The present meta-analysis was undertaken to (1) assess erythroid response rates in myelodysplastic syndromes (MDS) patients treated with epoetin alfa as a monotherapy, (2) gain further insights into predictors of response rates, and (3) compare the erythroid response rates …
The present meta-analysis was undertaken to (1) assess erythroid response rates in myelodysplastic syndromes (MDS) patients treated with epo …
Diagnosis and treatment of sideroblastic anemias: from defective heme synthesis to abnormal RNA splicing.
Cazzola M, Malcovati L. Cazzola M, et al. Hematology Am Soc Hematol Educ Program. 2015;2015:19-25. doi: 10.1182/asheducation-2015.1.19. Hematology Am Soc Hematol Educ Program. 2015. PMID: 26637696
X-linked sideroblastic anemia (XLSA) is caused by germline mutations in ALAS2. ...Autosomal recessive sideroblastic anemia attributable to mutations in SLC25A38, a member of the mitochondrial carrier family, is a severe disease: patients present in inf …
X-linked sideroblastic anemia (XLSA) is caused by germline mutations in ALAS2. ...Autosomal recessive sideroblastic …
Refractory anemia with ring sideroblasts (RARS) and RARS with thrombocytosis (RARS-T): 2017 update on diagnosis, risk-stratification, and management.
Patnaik MM, Tefferi A. Patnaik MM, et al. Am J Hematol. 2017 Mar;92(3):297-310. doi: 10.1002/ajh.24637. Am J Hematol. 2017. PMID: 28188970 Free PMC article. Review.
Disease outcome in MDS/MPN-RS-T is better than that of MDS-RS-SLD, but worse than that of essential thrombocythemia. Both diseases have a low risk of leukemic TREATMENT: Anemia and iron overload are complications seen in both and are managed similar to lower risk MDS and M …
Disease outcome in MDS/MPN-RS-T is better than that of MDS-RS-SLD, but worse than that of essential thrombocythemia. Both diseases have a lo …
Cardiovascular function and treatment in beta-thalassemia major: a consensus statement from the American Heart Association.
Pennell DJ, Udelson JE, Arai AE, Bozkurt B, Cohen AR, Galanello R, Hoffman TM, Kiernan MS, Lerakis S, Piga A, Porter JB, Walker JM, Wood J; American Heart Association Committee on Heart Failure and Transplantation of the Council on Clinical Cardiology and Council on Cardiovascular Radiology and Imaging. Pennell DJ, et al. Circulation. 2013 Jul 16;128(3):281-308. doi: 10.1161/CIR.0b013e31829b2be6. Epub 2013 Jun 17. Circulation. 2013. PMID: 23775258
The principles of diagnosis and treatment of cardiac iron loading in TM are directly relevant to other iron-overload conditions, including in particular Diamond-Blackfan anemia, sideroblastic anemia, and hereditary hemochromatosis. Heart failure is the most c …
The principles of diagnosis and treatment of cardiac iron loading in TM are directly relevant to other iron-overload conditions, including i …
Severe autoimmune cytopenias in treatment-naive hepatitis C virus infection: clinical description of 35 cases.
Ramos-Casals M, García-Carrasco M, López-Medrano F, Trejo O, Forns X, López-Guillermo A, Muñoz C, Ingelmo M, Font J. Ramos-Casals M, et al. Medicine (Baltimore). 2003 Mar;82(2):87-96. doi: 10.1097/00005792-200303000-00003. Medicine (Baltimore). 2003. PMID: 12640185 Free article. Review.
We considered active autoimmune hemolytic anemia (AHA) as a decrease of at least 2 g/dL in hemoglobin levels, an increase of at least 0.6 mg/dL in the serum unconjugated bilirubin level, a reticulocyte count >5%, and a positive direct Coombs test. ...We identified the f …
We considered active autoimmune hemolytic anemia (AHA) as a decrease of at least 2 g/dL in hemoglobin levels, an increase of at least …
Genotype/phenotype correlations of childhood-onset congenital sideroblastic anaemia in a European cohort.
Fouquet C, Le Rouzic MA, Leblanc T, Fouyssac F, Leverger G, Hessissen L, Marlin S, Bourrat E, Fahd M, Raffoux E, Vannier JP, Jäkel N, Knoefler R, Triolo V, Pasquet M, Bayart S, Thuret I, Lutz P, Vermylen C, Touati M, Rose C, Matthes T, Isidor B, Kannengiesser C, Ducassou S. Fouquet C, et al. Br J Haematol. 2019 Nov;187(4):530-542. doi: 10.1111/bjh.16100. Epub 2019 Jul 23. Br J Haematol. 2019. PMID: 31338833 Free article.
Congenital sideroblastic anaemia (CSA) is a rare disease caused by germline mutations of genes involved in haem and iron-sulphur cluster formation, and mitochondrial protein biosynthesis. ...Among the patients, the most frequently mutated genes were ALAS2 (n = 10; 2 …
Congenital sideroblastic anaemia (CSA) is a rare disease caused by germline mutations of genes involved in haem and iron-sulph …
16 results