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2010 1
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16 results

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A New Cellular Interactome of SARS-CoV-2 Nucleocapsid Protein and Its Biological Implications.
Min YQ, Huang M, Feng K, Jia Y, Sun X, Ning YJ. Min YQ, et al. Mol Cell Proteomics. 2023 Jul;22(7):100579. doi: 10.1016/j.mcpro.2023.100579. Epub 2023 May 20. Mol Cell Proteomics. 2023. PMID: 37211047 Free PMC article.
Furthermore, a newly identified host factor, DDX1, was verified to interact and colocalize with N mainly by binding to the N-terminal domain of the viral protein. Importantly, loss/gain/reconstitution-of-function experiments showed that DDX1 acts as a potent anti-SA …
Furthermore, a newly identified host factor, DDX1, was verified to interact and colocalize with N mainly by binding to the N-terminal domain …
Systematic analysis of nuclear localization of Autographa californica multiple nucleopolyhedrovirus proteins.
He L, Shao W, Li J, Deng F, Wang H, Hu Z, Wang M. He L, et al. J Gen Virol. 2021 Mar;102(3). doi: 10.1099/jgv.0.001517. Epub 2021 Jan 18. J Gen Virol. 2021. PMID: 33459587
Baculoviruses are large DNA viruses that replicate within the nucleus of infected host cells. Therefore, many viral proteins must gain access to the nucleus for efficient viral genome replication, gene transcription and virion assembly. ...This study presents the first glo …
Baculoviruses are large DNA viruses that replicate within the nucleus of infected host cells. Therefore, many viral proteins must gain …
Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways.
Huang SN, Zhou YP, Jiang X, Yang B, Cheng H, Luo MH. Huang SN, et al. Viruses. 2021 Apr 6;13(4):623. doi: 10.3390/v13040623. Viruses. 2021. PMID: 33917368 Free PMC article. Review.
In this review, we focus on the impact of CMV infection on the key players in inner ear development including the Wnt and Notch signaling pathways. Investigations on these interactions may gain new insights into viral pathogenesis and reveal novel targets for therapy....
In this review, we focus on the impact of CMV infection on the key players in inner ear development including the Wnt and Notch signaling pa …
Analysis of Synonymous Codon Usage Bias of Zika Virus and Its Adaption to the Hosts.
Wang H, Liu S, Zhang B, Wei W. Wang H, et al. PLoS One. 2016 Nov 28;11(11):e0166260. doi: 10.1371/journal.pone.0166260. eCollection 2016. PLoS One. 2016. PMID: 27893824 Free PMC article.
Codon usage bias analysis can reveal much about the molecular evolution and host adaption of ZIKV. To gain insight into the evolutionary characteristics of ZIKV, we performed a comprehensive analysis on the codon usage pattern in 46 ZIKV strains by calculating the effectiv …
Codon usage bias analysis can reveal much about the molecular evolution and host adaption of ZIKV. To gain insight into the evolution …
Genomic analysis of two Chinese isolates of hyphantria cunea nucleopolyhedrovirus reveals a novel species of alphabaculovirus that infects hyphantria cunea drury (lepidoptera: arctiidae).
Peng X, Zhang W, Lei C, Min S, Hu J, Wang Q, Sun X. Peng X, et al. BMC Genomics. 2022 May 13;23(1):367. doi: 10.1186/s12864-022-08604-7. BMC Genomics. 2022. PMID: 35562654 Free PMC article.
By analyzing non-synonymous variants, we found that hotspot mutation-containing genes had mainly unknown functions and most were early expressing genes. We found that the hycu78 gene which had early and late promoter was under positive selection. ...CONCLUSIONS: The genome …
By analyzing non-synonymous variants, we found that hotspot mutation-containing genes had mainly unknown functions and most were earl …
Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis.
Gao YR, Li DF, Fleming J, Zhou YF, Liu Y, Deng JY, Zhou L, Zhou J, Zhu GF, Zhang XE, Wang DC, Bi LJ. Gao YR, et al. Sci Rep. 2017 Jul 25;7(1):6471. doi: 10.1038/s41598-017-01705-4. Sci Rep. 2017. PMID: 28743871 Free PMC article.
Greater understanding of their underlying regulatory mechanism may open up new avenues for the effective treatment of bacterial infections. To gain molecular insight into the mechanism of Rv2887, a MarR family protein in M. tuberculosis, we first showed that it binds salic …
Greater understanding of their underlying regulatory mechanism may open up new avenues for the effective treatment of bacterial infections. …
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
Zhang LK, Xin QL, Zhu SL, Wan WW, Wang W, Xiao G. Zhang LK, et al. J Virol. 2016 Oct 28;90(22):10259-10270. doi: 10.1128/JVI.01292-16. Print 2016 Nov 15. J Virol. 2016. PMID: 27605671 Free PMC article.
Our study provides a possible explanation for how IFN-I can become activated during arenavirus infection and may help us gain insights into the interactions that form between different arenavirus components and the innate immune system....
Our study provides a possible explanation for how IFN-I can become activated during arenavirus infection and may help us gain insight …
Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly.
Mo Q, Xu Z, Deng F, Wang H, Ning YJ. Mo Q, et al. PLoS Pathog. 2020 Dec 7;16(12):e1009129. doi: 10.1371/journal.ppat.1009129. eCollection 2020 Dec. PLoS Pathog. 2020. PMID: 33284835 Free PMC article.
MOV10 that was further shown to be induced specifically by SFTSV and related bunyaviruses in turn inhibits the bunyaviral replication in infected cells in series of loss/gain-of-function assays. Moreover, animal infection experiments with MOV10 knockdown corroborate …
MOV10 that was further shown to be induced specifically by SFTSV and related bunyaviruses in turn inhibits the bunyaviral replication in inf …
PPARγ Is Activated during Congenital Cytomegalovirus Infection and Inhibits Neuronogenesis from Human Neural Stem Cells.
Rolland M, Li X, Sellier Y, Martin H, Perez-Berezo T, Rauwel B, Benchoua A, Bessières B, Aziza J, Cenac N, Luo M, Casper C, Peschanski M, Gonzalez-Dunia D, Leruez-Ville M, Davrinche C, Chavanas S. Rolland M, et al. PLoS Pathog. 2016 Apr 14;12(4):e1005547. doi: 10.1371/journal.ppat.1005547. eCollection 2016 Apr. PLoS Pathog. 2016. PMID: 27078877 Free PMC article.
Congenital infection by human cytomegalovirus (HCMV) is a leading cause of permanent sequelae of the central nervous system, including sensorineural deafness, cerebral palsies or devastating neurodevelopmental abnormalities (0.1% of all births). To gain insight on the impa …
Congenital infection by human cytomegalovirus (HCMV) is a leading cause of permanent sequelae of the central nervous system, including senso …
Immunogenicity of the spike glycoprotein of bat SARS-like coronavirus.
Hou YX, Peng C, Han ZG, Zhou P, Chen JG, Shi ZL. Hou YX, et al. Virol Sin. 2010 Feb;25(1):36-44. doi: 10.1007/s12250-010-3096-2. Epub 2010 Feb 12. Virol Sin. 2010. PMID: 20960282 Free PMC article.
Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental differenc …
Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular …
16 results