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Year Number of Results
1981 1
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1988 16
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1993 13
1994 16
1995 30
1996 22
1997 18
1998 32
1999 33
2000 32
2001 36
2002 40
2003 48
2004 56
2005 54
2006 78
2007 69
2008 83
2009 82
2010 105
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3,002 results

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Page 1
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Spangenberg E, Severson PL, Hohsfield LA, Crapser J, Zhang J, Burton EA, Zhang Y, Spevak W, Lin J, Phan NY, Habets G, Rymar A, Tsang G, Walters J, Nespi M, Singh P, Broome S, Ibrahim P, Zhang C, Bollag G, West BL, Green KN. Spangenberg E, et al. Nat Commun. 2019 Aug 21;10(1):3758. doi: 10.1038/s41467-019-11674-z. Nat Commun. 2019. PMID: 31434879 Free PMC article.
We designed and synthesized a highly selective brain-penetrant CSF1R inhibitor (PLX5622) allowing for extended and specific microglial elimination, preceding and during pathology development. We find that in the 5xFAD mouse model of AD, plaques fail to form in the parenchy …
We designed and synthesized a highly selective brain-penetrant CSF1R inhibitor (PLX5622) allowing for extended and specific microglial elimi …
A cellular and molecular spatial atlas of dystrophic muscle.
Stec MJ, Su Q, Adler C, Zhang L, Golann DR, Khan NP, Panagis L, Villalta SA, Ni M, Wei Y, Walls JR, Murphy AJ, Yancopoulos GD, Atwal GS, Kleiner S, Halasz G, Sleeman MW. Stec MJ, et al. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2221249120. doi: 10.1073/pnas.2221249120. Epub 2023 Jul 6. Proc Natl Acad Sci U S A. 2023. PMID: 37410813 Free PMC article.
Asynchronous skeletal muscle degeneration/regeneration is a hallmark feature of Duchenne muscular dystrophy (DMD); however, traditional -omics technologies that lack spatial context make it difficult to study the biological mechanisms of how asynchronous regeneration contributes …
Asynchronous skeletal muscle degeneration/regeneration is a hallmark feature of Duchenne muscular dystrophy (DMD); however, traditional -omi …
Current In Vivo Models of Varicella-Zoster Virus Neurotropism.
Mahalingam R, Gershon A, Gershon M, Cohen JI, Arvin A, Zerboni L, Zhu H, Gray W, Messaoudi I, Traina-Dorge V. Mahalingam R, et al. Viruses. 2019 May 31;11(6):502. doi: 10.3390/v11060502. Viruses. 2019. PMID: 31159224 Free PMC article. Review.
An understanding of VZV neurotropism in humans has long been hampered by the lack of an adequate animal model. For example, experimental inoculation of VZV in small animals including guinea pigs and cotton rats results in the infection of ganglia but n …
An understanding of VZV neurotropism in humans has long been hampered by the lack of an adequate animal model. For example, experimen …
Cerebrovascular phenotypes in mouse models of Alzheimer's disease.
Szu JI, Obenaus A. Szu JI, et al. J Cereb Blood Flow Metab. 2021 Aug;41(8):1821-1841. doi: 10.1177/0271678X21992462. Epub 2021 Feb 8. J Cereb Blood Flow Metab. 2021. PMID: 33557692 Free PMC article. Review.
In this review, we delve into known structural and functional vascular alterations in various mouse models of AD and the cellular and molecular constituents that influence these changes to further disease progression. ...
In this review, we delve into known structural and functional vascular alterations in various mouse models of AD and the cellular and …
Borna disease virus.
Jordan I, Lipkin WI. Jordan I, et al. Rev Med Virol. 2001 Jan-Feb;11(1):37-57. doi: 10.1002/rmv.300. Rev Med Virol. 2001. PMID: 11241801 Free PMC article. Review.
Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species. Unlike other non-segmented negative-strand RNA animal viruses, BDV replicates in t …
Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolyti …
Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer's Disease.
Dunham SJB, McNair KA, Adams ED, Avelar-Barragan J, Forner S, Mapstone M, Whiteson KL. Dunham SJB, et al. mBio. 2022 Dec 20;13(6):e0179422. doi: 10.1128/mbio.01794-22. Epub 2022 Dec 5. mBio. 2022. PMID: 36468884 Free PMC article.
Taken together, these findings strengthen the link between Turicibacter abundance and AD, provide a basis for further microbiome studies of murine models for AD, and suggest that greater control over animal model microbiomes is needed in AD research. ...Here, we pre …
Taken together, these findings strengthen the link between Turicibacter abundance and AD, provide a basis for further microbiome studies of …
Antioxidants in Down syndrome.
Lott IT. Lott IT. Biochim Biophys Acta. 2012 May;1822(5):657-63. doi: 10.1016/j.bbadis.2011.12.010. Epub 2011 Dec 21. Biochim Biophys Acta. 2012. PMID: 22206998 Free PMC article. Review.
Individuals with Down syndrome (DS) have high levels of oxidative stress throughout the lifespan. Mouse models of DS share some structural and functional abnormalities that parallel findings seen in the human phenotype. Several of the mouse models show evidence of c …
Individuals with Down syndrome (DS) have high levels of oxidative stress throughout the lifespan. Mouse models of DS share some struc …
Evaluation of the clinical relevance of vancomycin for the treatment of Lyme disease.
Wormser GP, Barbour AG. Wormser GP, et al. Wien Klin Wochenschr. 2023 Apr;135(7-8):185-189. doi: 10.1007/s00508-019-1505-6. Epub 2019 May 10. Wien Klin Wochenschr. 2023. PMID: 31076888
Vancomycin is active in vitro and in vivo in mouse systems against Lyme disease borrelia; however, there are no published data on the efficacy of vancomycin in patients with Lyme disease and no convincing theoretical advantages of vancomycin over the currentl …
Vancomycin is active in vitro and in vivo in mouse systems against Lyme disease borrelia; however, there are no publish …
Development of zirconium-89 PET for in vivo imaging of alpha-klotho.
Lau WL, Liang C, Liu H, Singh K, Mukherjee J. Lau WL, et al. Am J Nucl Med Mol Imaging. 2020 Apr 15;10(2):95-105. eCollection 2020. Am J Nucl Med Mol Imaging. 2020. PMID: 32419978 Free PMC article.
For in vivo testing, C57BL/6J mice were injected retro-orbitally with [(89)Zr]DFO-anti-mKlotho and were scanned using Inveon PET/CT. ...In summary, we have successfully synthesized [(89)Zr]DFO-anti-mKlotho and our initial in vitro and in vivo st …
For in vivo testing, C57BL/6J mice were injected retro-orbitally with [(89)Zr]DFO-anti-mKlotho and were scanned using I …
Interneuron Transplantation as a Treatment for Epilepsy.
Hunt RF, Baraban SC. Hunt RF, et al. Cold Spring Harb Perspect Med. 2015 Dec 1;5(12):a022376. doi: 10.1101/cshperspect.a022376. Cold Spring Harb Perspect Med. 2015. PMID: 26627452 Free PMC article. Review.
Here, we review recent efforts to isolate and transplant cortical interneuron precursors derived from embryonic mouse and human cell sources. We also discuss some of the important challenges that must be addressed before stem-cell-based treatment for human epilepsy is real …
Here, we review recent efforts to isolate and transplant cortical interneuron precursors derived from embryonic mouse and human cell …
3,002 results