Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1976 1
1979 1
1982 1
1983 1
1984 1
1985 2
1986 1
1987 5
1988 17
1989 20
1990 17
1991 17
1992 20
1993 33
1994 25
1995 26
1996 20
1997 23
1998 26
1999 28
2000 19
2001 23
2002 43
2003 37
2004 44
2005 50
2006 64
2007 57
2008 48
2009 35
2010 38
2011 41
2012 49
2013 62
2014 74
2015 81
2016 87
2017 90
2018 74
2019 108
2020 79
2021 102
2022 84
2023 79
2024 21

Text availability

Article attribute

Article type

Publication date

Search Results

1,615 results

Results by year

Filters applied: . Clear all
Page 1
Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia.
Zhao N, Qiao W, Li F, Ren Y, Zheng J, Martens YA, Wang X, Li L, Liu CC, Chen K, Zhu Y, Ikezu TC, Li Z, Meneses AD, Jin Y, Knight JA, Chen Y, Bastea L, Linares C, Sonustun B, Job L, Smith ML, Xie M, Liu YU, Umpierre AD, Haruwaka K, Quicksall ZS, Storz P, Asmann YW, Wu LJ, Bu G. Zhao N, et al. J Exp Med. 2022 Dec 5;219(12):e20212479. doi: 10.1084/jem.20212479. Epub 2022 Sep 15. J Exp Med. 2022. PMID: 36107206 Free PMC article.
However, the effective therapeutic window targeting TREM2 is unclear. Here, by using microglia-specific inducible mouse models overexpressing human wild-type TREM2 (TREM2-WT) or R47H risk variant (TREM2-R47H), we show that TREM2-WT expression reduces amyloid deposition and …
However, the effective therapeutic window targeting TREM2 is unclear. Here, by using microglia-specific inducible mouse models overex …
Schlafens: Emerging Proteins in Cancer Cell Biology.
Al-Marsoummi S, Vomhof-DeKrey EE, Basson MD. Al-Marsoummi S, et al. Cells. 2021 Aug 29;10(9):2238. doi: 10.3390/cells10092238. Cells. 2021. PMID: 34571887 Free PMC article. Review.
This review will briefly summarize the history, structure, and non-malignant biological functions of Schlafens. The roles of human and mouse Schlafens in different cancer types will then be outlined. ...
This review will briefly summarize the history, structure, and non-malignant biological functions of Schlafens. The roles of human and mo …
Probing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice.
Buffenstein R, Lewis KN, Gibney PA, Narayan V, Grimes KM, Smith M, Lin TD, Brown-Borg HM. Buffenstein R, et al. Physiology (Bethesda). 2020 Mar 1;35(2):96-111. doi: 10.1152/physiol.00032.2019. Physiology (Bethesda). 2020. PMID: 32024425 Free article. Review.
., slow growth rates, low hormone levels, and delayed sexual maturity) are shared with spontaneously mutated, long-lived dwarf mice. Although some youthful traits likely evolved as adaptations to subterranean habitats (e.g., thermolability), the nature of these intrinsic p …
., slow growth rates, low hormone levels, and delayed sexual maturity) are shared with spontaneously mutated, long-lived dwarf mice. …
Function of SLAM-Associated Protein (SAP) in Acute Pneumoseptic Bacterial Infection.
Tripathi JK, Sharma A, Gupta K, Abdelrahman H, Chauhan P, Mishra BB, Sharma J. Tripathi JK, et al. J Mol Biol. 2019 Oct 4;431(21):4345-4353. doi: 10.1016/j.jmb.2019.07.002. Epub 2019 Jul 8. J Mol Biol. 2019. PMID: 31295456 Review.
Here we report a previously unrecognized innate protective function of SAP, an adaptor protein primarily reported in T cells, NK cells, and NKT cells, during acute pneumonic infection with Klebsiella pneumoniae (KPn). SAP-deficient mice were highly susceptible to this infe …
Here we report a previously unrecognized innate protective function of SAP, an adaptor protein primarily reported in T cells, NK cells, and …
GH and IGF1: roles in energy metabolism of long-living GH mutant mice.
Brown-Borg HM, Bartke A. Brown-Borg HM, et al. J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):652-60. doi: 10.1093/gerona/gls086. Epub 2012 Mar 30. J Gerontol A Biol Sci Med Sci. 2012. PMID: 22466316 Free PMC article. Review.
Mitochondrial metabolism is upregulated in the absence of GH, whereas in GH transgenic mice and dwarf mice treated with GH, multiple aspects of these pathways are suppressed. Core body temperature is markedly lower in dwarf mice, yet whole-body metabolism, as …
Mitochondrial metabolism is upregulated in the absence of GH, whereas in GH transgenic mice and dwarf mice treated with GH, mu …
Host transcriptome response to Borrelia burgdorferi sensu lato.
Thompson D, Watt JA, Brissette CA. Thompson D, et al. Ticks Tick Borne Dis. 2021 Mar;12(2):101638. doi: 10.1016/j.ttbdis.2020.101638. Epub 2020 Dec 13. Ticks Tick Borne Dis. 2021. PMID: 33360384 Free PMC article. Review.
Effects of Probiotics on Colitis-Induced Exacerbation of Alzheimer's Disease in App(NL-G-F) Mice.
Sahu B, Johnson LM, Sohrabi M, Usatii AA, Craig RMJ, Kaelberer JB, Chandrasekaran SP, Kaur H, Nookala S, Combs CK. Sahu B, et al. Int J Mol Sci. 2023 Jul 17;24(14):11551. doi: 10.3390/ijms241411551. Int J Mol Sci. 2023. PMID: 37511312 Free PMC article.
Previously, we separately demonstrated that an IBD-like condition exacerbates AD-related changes in the brains of the App(NL-G-F) mouse model of AD, while probiotic intervention has an attenuating effect. In this study, we investigated the combination of a dietary probioti …
Previously, we separately demonstrated that an IBD-like condition exacerbates AD-related changes in the brains of the App(NL-G-F) mouse …
Liver Bile Acid Changes in Mouse Models of Alzheimer's Disease.
Kaur H, Seeger D, Golovko S, Golovko M, Combs CK. Kaur H, et al. Int J Mol Sci. 2021 Jul 12;22(14):7451. doi: 10.3390/ijms22147451. Int J Mol Sci. 2021. PMID: 34299071 Free PMC article.
This study was performed to better understand the role of liver cholesterol and bile acid metabolism in the pathophysiology of AD. We used male and female wild-type control (C57BL/6J) mice to compare to two well-characterized amyloidosis models of AD, APP/PS1, and App(NL-G …
This study was performed to better understand the role of liver cholesterol and bile acid metabolism in the pathophysiology of AD. We used m …
Systems Genetics Approaches in Mouse Models of Group A Streptococcal Necrotizing Soft-Tissue Infections.
Nookala S, Krishnan KC, Mukundan S, Kotb M. Nookala S, et al. Adv Exp Med Biol. 2020;1294:151-166. doi: 10.1007/978-3-030-57616-5_10. Adv Exp Med Biol. 2020. PMID: 33079368 Review.
This leads to a pro-inflammatory cytokine storm and the subsequent multiple organ damage and shock. Inbred mice are innately refractive to SAg-mediated responses. In this chapter, we discuss the versatility of the HLA-II transgenic mouse model that allowed the biolo …
This leads to a pro-inflammatory cytokine storm and the subsequent multiple organ damage and shock. Inbred mice are innately refracti …
Multifactorial Attenuation of the Murine Heat Shock Response With Age.
Jurivich DA, Manocha GD, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H. Jurivich DA, et al. J Gerontol A Biol Sci Med Sci. 2020 Sep 25;75(10):1846-1852. doi: 10.1093/gerona/glz204. J Gerontol A Biol Sci Med Sci. 2020. PMID: 31612204 Free PMC article.
When comparing liver extracts from middle aged (12 M) and old (24 M) mice, significant differences are found in HSF1 phosphorylation and acetylation. ...
When comparing liver extracts from middle aged (12 M) and old (24 M) mice, significant differences are found in HSF1 phosphorylation …
1,615 results