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Page 1
Agammaglobulinemia: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management.
Pashangzadeh S, Yazdani R, Nazari F, Azizi G, Abolhassani H, Aghamohammadi A. Pashangzadeh S, et al. Endocr Metab Immune Disord Drug Targets. 2020;20(9):1434-1447. doi: 10.2174/1871530320666200508114349. Endocr Metab Immune Disord Drug Targets. 2020. PMID: 32384040 Review.
Agammaglobulinemia is a type of primary antibody deficiencies, characterized by severe reduction in serum level of all types of immunoglobulins level and absence of B cells in the peripheral blood. ...Affected patients present a broad range of clinical manifestations, incl …
Agammaglobulinemia is a type of primary antibody deficiencies, characterized by severe reduction in serum level of all types of immun …
Ibrutinib-associated bleeding: pathogenesis, management and risk reduction strategies.
Shatzel JJ, Olson SR, Tao DL, McCarty OJT, Danilov AV, DeLoughery TG. Shatzel JJ, et al. J Thromb Haemost. 2017 May;15(5):835-847. doi: 10.1111/jth.13651. Epub 2017 Mar 27. J Thromb Haemost. 2017. PMID: 28182323 Free PMC article. Review.
Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (Btk) that has proven to be an effective therapeutic agent for multiple B-cell-mediated lymphoproliferative disorders. ...There is currently a minimal amount of data to guide clinicians regarding the use of …
Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (Btk) that has proven to be an effective therapeutic agent for mul …
Diagnosis and treatment of gastrointestinal disorders in patients with primary immunodeficiency.
Agarwal S, Mayer L. Agarwal S, et al. Clin Gastroenterol Hepatol. 2013 Sep;11(9):1050-63. doi: 10.1016/j.cgh.2013.02.024. Epub 2013 Mar 13. Clin Gastroenterol Hepatol. 2013. PMID: 23501398 Free PMC article. Review.
Therapies for primary immunodeficiency comprise immunoglobulin replacement, antibiotics, and, in severe cases, bone marrow transplantation. Treatment of immunodeficient patients with concomitant gastrointestinal disease can be challenging, and therapy with immunomod …
Therapies for primary immunodeficiency comprise immunoglobulin replacement, antibiotics, and, in severe cases, bone marrow transplant …
A Novel Point-of-Care Rapid Diagnostic Test for Screening Individuals for Antibody Deficiencies.
Israeli S, Golden A, Atalig M, Mekki N, Rais A, Storey H, Barbouche MR, Peck R. Israeli S, et al. J Clin Immunol. 2022 Feb;42(2):394-403. doi: 10.1007/s10875-021-01179-0. Epub 2021 Nov 27. J Clin Immunol. 2022. PMID: 34839430 Free PMC article.
METHODS: Three prototype tests distinguishing low and normal IgG levels were evaluated with a blinded panel of serum/plasma specimens from 32 healthy controls and 86 primary immunodeficiency-confirmed patients with agammaglobulinemia, common variable immunodeficiency, and …
METHODS: Three prototype tests distinguishing low and normal IgG levels were evaluated with a blinded panel of serum/plasma specimens from 3 …
COVID-19-related health outcomes in people with primary immunodeficiency: A systematic review.
Drzymalla E, Green RF, Knuth M, Khoury MJ, Dotson WD, Gundlapalli A. Drzymalla E, et al. Clin Immunol. 2022 Oct;243:109097. doi: 10.1016/j.clim.2022.109097. Epub 2022 Aug 13. Clin Immunol. 2022. PMID: 35973637 Free PMC article. Review.
In addition to being up-to-date on vaccinations, current strategies for optimizing protection for people with PI can include pre-exposure prophylaxis for those eligible and use of therapeutics. Overall, people with PI, when infected, tested positive and showed symptoms for …
In addition to being up-to-date on vaccinations, current strategies for optimizing protection for people with PI can include pre-exposure pr …
Treatment of chronic or relapsing COVID-19 in immunodeficiency.
Brown LK, Moran E, Goodman A, Baxendale H, Bermingham W, Buckland M, AbdulKhaliq I, Jarvis H, Hunter M, Karanam S, Patel A, Jenkins M, Robbins A, Khan S, Simpson T, Jolles S, Underwood J, Savic S, Richter A, Shields A, Brown M, Lowe DM. Brown LK, et al. J Allergy Clin Immunol. 2022 Feb;149(2):557-561.e1. doi: 10.1016/j.jaci.2021.10.031. Epub 2021 Nov 12. J Allergy Clin Immunol. 2022. PMID: 34780850 Free PMC article.
Their underlying immunodeficiency was most commonly characterized by antibody deficiency with absent or profoundly reduced peripheral B-cell levels; prior anti-CD20 therapy, and X-linked agammaglobulinemia. Their clinical features of COVID-19 were similar to those o …
Their underlying immunodeficiency was most commonly characterized by antibody deficiency with absent or profoundly reduced peripheral B-cell …
Who's your data? Primary immune deficiency differential diagnosis prediction via machine learning and data mining of the USIDNET registry.
Méndez Barrera JA, Rocha Guzmán S, Hierro Cascajares E, Garabedian EK, Fuleihan RL, Sullivan KE, Lugo Reyes SO. Méndez Barrera JA, et al. Clin Immunol. 2023 Oct;255:109759. doi: 10.1016/j.clim.2023.109759. Epub 2023 Sep 9. Clin Immunol. 2023. PMID: 37678719
RESULTS: The twelve PID diagnoses were CVID (1098 patients), DiGeorge syndrome, Chronic granulomatous disease, Congenital agammaglobulinemia, PID not otherwise classified, Specific antibody deficiency, Complement deficiency, Hyper-IgM, Leukocyte adhesion deficiency, ectode …
RESULTS: The twelve PID diagnoses were CVID (1098 patients), DiGeorge syndrome, Chronic granulomatous disease, Congenital agammaglobuline …
From identification of the BTK kinase to effective management of leukemia.
Smith CI. Smith CI. Oncogene. 2017 Apr;36(15):2045-2053. doi: 10.1038/onc.2016.343. Epub 2016 Sep 26. Oncogene. 2017. PMID: 27669440 Free PMC article. Review.
BTK was initially identified by positional cloning of the gene causing X-linked agammaglobulinemia and independently in a search for new kinases. Given the phenotype of affected patients, namely lack of B-lymphocytes and plasma cells with the ensuing inability to mount hum …
BTK was initially identified by positional cloning of the gene causing X-linked agammaglobulinemia and independently in a search for …
Splice-correction strategies for treatment of X-linked agammaglobulinemia.
Bestas B, Turunen JJ, Blomberg KE, Wang Q, Månsson R, El Andaloussi S, Berglöf A, Smith CI. Bestas B, et al. Curr Allergy Asthma Rep. 2015 Mar;15(3):510. doi: 10.1007/s11882-014-0510-0. Curr Allergy Asthma Rep. 2015. PMID: 25638286 Free PMC article. Review.
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease caused by mutations in the gene coding for Bruton's tyrosine kinase (BTK). ...A substantial portion of the mutations in BTK results in splicing defects, consequently preventing the formation of protein …
X-linked agammaglobulinemia (XLA) is a primary immunodeficiency disease caused by mutations in the gene coding for Bruton's tyrosine …
Prenatal diagnosis and genetic analysis of X-linked immunodeficiency disorders.
Puck JM. Puck JM. Pediatr Res. 1993 Jan;33(1 Suppl):S29-33; discussion S33-4. doi: 10.1203/00006450-199305001-00158. Pediatr Res. 1993. PMID: 8433872 Review.
Several congenital immunodeficiency diseases can exhibit X-linked inheritance, including agammaglobulinemia, severe combined immunodeficiency, Wiskott-Aldrich syndrome, X-linked lymphoproliferative syndrome, and X-linked hyper-IgM syndrome. ...As a partial solution to this …
Several congenital immunodeficiency diseases can exhibit X-linked inheritance, including agammaglobulinemia, severe combined immunode …
72 results