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Year Number of Results
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2001 1
2006 1
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2014 3
2015 1
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2020 3
2021 1
2024 0

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18 results

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Page 1
Fighting Alzheimer's disease and type 2 diabetes: pathological links and treatment strategies.
Dai Y, Kamal MA. Dai Y, et al. CNS Neurol Disord Drug Targets. 2014 Mar;13(2):271-82. doi: 10.2174/18715273113126660134. CNS Neurol Disord Drug Targets. 2014. PMID: 24059324 Review.
Emerging evidence indicates that AD and T2DM share some common risk factors with comparable pathological features including insulin resistance, amyloidogenesis, glucocorticoid imbalance, inflammation, mitochondrial function and oxidative stress. ...This review summarizes r …
Emerging evidence indicates that AD and T2DM share some common risk factors with comparable pathological features including insulin resistan …
Targeting transthyretin - Mechanism-based treatment approaches and future perspectives in hereditary amyloidosis.
Dohrn MF, Ihne S, Hegenbart U, Medina J, Züchner SL, Coelho T, Hahn K. Dohrn MF, et al. J Neurochem. 2021 Mar;156(6):802-818. doi: 10.1111/jnc.15233. Epub 2020 Dec 3. J Neurochem. 2021. PMID: 33155274 Free article.
The liver-derived, circulating transport protein transthyretin (TTR) is the cause of systemic hereditary (ATTRv) and wild-type (ATTRwt) amyloidosis. TTR stabilization and knockdown are approved therapies to mitigate the otherwise lethal disease course. To date, the variety …
The liver-derived, circulating transport protein transthyretin (TTR) is the cause of systemic hereditary (ATTRv) and wild-type (ATTRwt) amyl …
Amyloidosis in Inflammatory Bowel Disease: A Systematic Review of Epidemiology, Clinical Features, and Treatment.
Tosca Cuquerella J, Bosca-Watts MM, Anton Ausejo R, Tejedor Alonso S, Mora De Miguel F, Minguez Perez M. Tosca Cuquerella J, et al. J Crohns Colitis. 2016 Oct;10(10):1245-53. doi: 10.1093/ecco-jcc/jjw080. Epub 2016 Apr 7. J Crohns Colitis. 2016. PMID: 27056947 Review.
BACKGROUND AND AIMS: Amyloidosis is a rare complication of inflammatory bowel disease [IBD]; its low prevalence has hindered both descriptive and therapeutic studies. The aim of this study was to estimate the prevalence of amyloidosis in IBD and the risk factors associated …
BACKGROUND AND AIMS: Amyloidosis is a rare complication of inflammatory bowel disease [IBD]; its low prevalence has hindered both descriptiv …
Pathogenesis, diagnosis and treatment of systemic amyloidosis.
Pepys MB. Pepys MB. Philos Trans R Soc Lond B Biol Sci. 2001 Feb 28;356(1406):203-10; discussion 210-1. doi: 10.1098/rstb.2000.0766. Philos Trans R Soc Lond B Biol Sci. 2001. PMID: 11260801 Free PMC article. Review.
In addition to the fibrils, amyloid deposits always contain the non-fibrillar pentraxin plasma protein, serum amyloid P component (SAP), because it undergoes specific calcium-dependent binding to amyloid fibrils. SAP contributes to amyloidogenesis, probably by stabilizing …
In addition to the fibrils, amyloid deposits always contain the non-fibrillar pentraxin plasma protein, serum amyloid P component (SAP), bec …
Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidence.
Tobinick E. Tobinick E. CNS Drugs. 2009 Sep;23(9):713-25. doi: 10.2165/11310810-000000000-00000. CNS Drugs. 2009. PMID: 19689163 Review.
TNF may also play a role in endothelial and microvascular dysfunction in AD, and in amyloidogenesis and amyloid-induced memory dysfunction in AD. Genetic and epidemiological evidence has implicated increased TNF production as a risk factor for AD. ...
TNF may also play a role in endothelial and microvascular dysfunction in AD, and in amyloidogenesis and amyloid-induced memory dysfun …
The antidepressant drug; trazodone inhibits Tau amyloidogenesis: Prospects for prophylaxis and treatment of AD.
Akbari V, Ghobadi S, Mohammadi S, Khodarahmi R. Akbari V, et al. Arch Biochem Biophys. 2020 Jan 15;679:108218. doi: 10.1016/j.abb.2019.108218. Epub 2019 Dec 2. Arch Biochem Biophys. 2020. PMID: 31805267
Trazodone (TRZ), a triazolopyridine derivative, is a selective serotonin reuptake inhibitor (SSRI) which increases serotonin levels in synaptic cleft and potentiating serotonin activity, with antidepressant and sedative properties. This drug is more effective and tolerable than o …
Trazodone (TRZ), a triazolopyridine derivative, is a selective serotonin reuptake inhibitor (SSRI) which increases serotonin levels in synap …
Anti-amyloid drugs: potential in the treatment of diseases associated with aging.
Kisilevsky R. Kisilevsky R. Drugs Aging. 1996 Feb;8(2):75-83. doi: 10.2165/00002512-199608020-00001. Drugs Aging. 1996. PMID: 8845588 Review.
The requirements for amyloidogenesis, as it is currently understood, include an adequate amyloid precursor pool, a nidus for fibrillogenesis, interactions with a set of common components (most of which are involved in basement membrane structure) and amyloid turnover. Thes …
The requirements for amyloidogenesis, as it is currently understood, include an adequate amyloid precursor pool, a nidus for fibrillo …
Serotonin Selective Reuptake Inhibitor Treatment Improves Cognition and Grey Matter Atrophy but not Amyloid Burden During Two-Year Follow-Up in Mild Cognitive Impairment and Alzheimer's Disease Patients with Depressive Symptoms.
Brendel M, Sauerbeck J, Greven S, Kotz S, Scheiwein F, Blautzik J, Delker A, Pogarell O, Ishii K, Bartenstein P, Rominger A; Alzheimer’s Disease Neuroimaging Initiative. Brendel M, et al. J Alzheimers Dis. 2018;65(3):793-806. doi: 10.3233/JAD-170387. J Alzheimers Dis. 2018. PMID: 30010116
Preclinical studies have suggested that serotonin selective reuptake inhibitors (SSRIs) can attenuate amyloidogenesis. Therefore, we aimed to investigate the effect of SSRI medication on amyloidosis and grey matter volume in subsyndromal depressed subjects with MCI and AD …
Preclinical studies have suggested that serotonin selective reuptake inhibitors (SSRIs) can attenuate amyloidogenesis. Therefore, we …
18 results