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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 2
1998 2
2000 1
2001 1
2003 1
2004 1
2010 2
2011 1
2013 1
2014 1
2015 2
2016 2
2018 2
2019 3
2023 2
2024 0

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23 results

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Page 1
Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients.
Zhang N, Gordon ML. Zhang N, et al. Clin Interv Aging. 2018 Oct 11;13:1963-1970. doi: 10.2147/CIA.S159920. eCollection 2018. Clin Interv Aging. 2018. PMID: 30349215 Free PMC article. Review.
In this review, we discuss 1) the efficacy of donepezil and its comparison with other AChEIs or memantine, 2) the therapeutic responses to donepezil and its influencing factors, and 3) the safety and tolerability of donepezil in Chinese patients with different stages of AD …
In this review, we discuss 1) the efficacy of donepezil and its comparison with other AChEIs or memantine, 2) the therapeutic respons …
Fatigue in Alzheimer's disease: biological basis and clinical management-a narrative review.
Angioni D, Raffin J, Ousset PJ, Delrieu J, de Souto Barreto P. Angioni D, et al. Aging Clin Exp Res. 2023 Oct;35(10):1981-1989. doi: 10.1007/s40520-023-02482-z. Epub 2023 Jul 3. Aging Clin Exp Res. 2023. PMID: 37395951 Review.
Fatigue and neurodegeneration of Alzheimer's disease could share common brain signatures (i.e. hippocampal atrophy and periventricular leukoaraiosis). Some mechanisms of aging (i.e. inflammation, mitochondrial dysfunction, telomere shortening) may be proposed to pla …
Fatigue and neurodegeneration of Alzheimer's disease could share common brain signatures (i.e. hippocampal atrophy and periven …
Hippocampal neurogenesis as a target for the treatment of mental illness: a critical evaluation.
DeCarolis NA, Eisch AJ. DeCarolis NA, et al. Neuropharmacology. 2010 May;58(6):884-93. doi: 10.1016/j.neuropharm.2009.12.013. Epub 2010 Jan 6. Neuropharmacology. 2010. PMID: 20060007 Free PMC article. Review.
In particular, preclinical and clinical research suggests that hippocampal neurogenesis, the generation of new neurons in the adult dentate gyrus, may be harnessed to treat mental illness. There are obvious applications and allures of this approach; for example, perhaps st …
In particular, preclinical and clinical research suggests that hippocampal neurogenesis, the generation of new neurons in the adult d …
Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.
Jack CR Jr, Petersen RC, Xu YC, O'Brien PC, Waring SC, Tangalos EG, Smith GE, Ivnik RJ, Thibodeau SN, Kokmen E. Jack CR Jr, et al. Ann Neurol. 1998 Mar;43(3):303-10. doi: 10.1002/ana.410430307. Ann Neurol. 1998. PMID: 9506546 Free PMC article. Review.
One of the strongest imaging associations identified is between AD and hippocampal atrophy. The epsilon4 allele of the apolipoprotein E (ApoE) gene increases the risk of developing AD and lowers the mean age of onset of the disease. ...Both the epsilon4 allele of Ap …
One of the strongest imaging associations identified is between AD and hippocampal atrophy. The epsilon4 allele of the apolipo …
Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence.
Freiherr J, Hallschmid M, Frey WH 2nd, Brünner YF, Chapman CD, Hölscher C, Craft S, De Felice FG, Benedict C. Freiherr J, et al. CNS Drugs. 2013 Jul;27(7):505-14. doi: 10.1007/s40263-013-0076-8. CNS Drugs. 2013. PMID: 23719722 Free PMC article. Review.
These results, in conjunction with the finding that insulin mitigates hippocampal synapse vulnerability to beta amyloid, a peptide thought to be causative in the development of AD, provide a strong rationale for hypothesizing that pharmacological strategies bolstering brai …
These results, in conjunction with the finding that insulin mitigates hippocampal synapse vulnerability to beta amyloid, a peptide th …
Functional disconnectivity of the hippocampal network and neural correlates of memory impairment in treatment-resistant depression.
Ge R, Torres I, Brown JJ, Gregory E, McLellan E, Downar JH, Blumberger DM, Daskalakis ZJ, Lam RW, Vila-Rodriguez F. Ge R, et al. J Affect Disord. 2019 Jun 15;253:248-256. doi: 10.1016/j.jad.2019.04.096. Epub 2019 Apr 29. J Affect Disord. 2019. PMID: 31060011
Neuroimaging studies have consistently linked memory deficits with hippocampal atrophy in MDD patients. However, there has been a paucity of research examining how the hippocampus functionally contributes to memory impairments in MDD. ...Task-based imaging studies a …
Neuroimaging studies have consistently linked memory deficits with hippocampal atrophy in MDD patients. However, there has bee …
Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum.
Liu Y, Tan L, Wang HF, Liu Y, Hao XK, Tan CC, Jiang T, Liu B, Zhang DQ, Yu JT; Alzheimer’s Disease Neuroimaging Initiative. Liu Y, et al. Mol Neurobiol. 2016 Sep;53(7):4539-47. doi: 10.1007/s12035-015-9388-7. Epub 2015 Aug 23. Mol Neurobiol. 2016. PMID: 26298664
A total of 1718 participants from the ADNI cohort were selected, and we evaluated the impact of epsilon4 dose on cerebrospinal fluid (CSF) levels' Abeta1-42 (Abeta1-42), tau, and phosphorylated-tau (p-tau); cortical amyloid deposition (Florbetapir-PET-AV45); brain atrophy …
A total of 1718 participants from the ADNI cohort were selected, and we evaluated the impact of epsilon4 dose on cerebrospinal fluid (CSF) l …
Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling.
Finegan E, Li Hi Shing S, Chipika RH, Doherty MA, Hengeveld JC, Vajda A, Donaghy C, Pender N, McLaughlin RL, Hardiman O, Bede P. Finegan E, et al. Neuroimage Clin. 2019;24:102089. doi: 10.1016/j.nicl.2019.102089. Epub 2019 Nov 12. Neuroimage Clin. 2019. PMID: 31795059 Free PMC article.
The hippocampus was further parcellated to characterise the involvement of specific subfields. RESULTS: Considerable thalamic, caudate, and hippocampal atrophy was detected in PLS based on both volumetric and vertex analyses. Significant volume reductions were also …
The hippocampus was further parcellated to characterise the involvement of specific subfields. RESULTS: Considerable thalamic, caudate, and …
Influence of APOE Genotype on Hippocampal Atrophy over Time - An N=1925 Surface-Based ADNI Study.
Li B, Shi J, Gutman BA, Baxter LC, Thompson PM, Caselli RJ, Wang Y; Alzheimer’s Disease Neuroimaging Initiative. Li B, et al. PLoS One. 2016 Apr 11;11(4):e0152901. doi: 10.1371/journal.pone.0152901. eCollection 2016. PLoS One. 2016. PMID: 27065111 Free PMC article.
We now examine the longitudinal effects of APOE genotype on hippocampal morphometry at 6-, 12- and 24-months, in the ADNI cohort. ...These findings, combined with our earlier investigations, demonstrate an e4 dose effect on accelerated hippocampal atrophy, an …
We now examine the longitudinal effects of APOE genotype on hippocampal morphometry at 6-, 12- and 24-months, in the ADNI cohort. ... …
NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia.
Ballard CG, Burton EJ, Barber R, Stephens S, Kenny RA, Kalaria RN, O'Brien JT. Ballard CG, et al. Neurology. 2004 Sep 28;63(6):983-8. doi: 10.1212/01.wnl.0000138435.19761.93. Neurology. 2004. PMID: 15452287
The proportion of patients with and without poststroke dementia meeting the imaging component of the NINDS AIREN criteria was determined, and hippocampal atrophy (measured using the Schelten scale) was compared between the two groups. ...In addition, there were no s …
The proportion of patients with and without poststroke dementia meeting the imaging component of the NINDS AIREN criteria was determined, an …
23 results