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Page 1
"Root"ing for successful T-ALL treatment.
Padi SKR, Kraft AS. Padi SKR, et al. Blood. 2021 May 6;137(18):2422-2423. doi: 10.1182/blood.2020009748. Blood. 2021. PMID: 33956068 Free PMC article.
In this issue of Blood, Anand et al provide compelling evidence that resistance to Notch inhibitor therapy in early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) occurs as a result of an activated phosphatidylinositol 3-k …
In this issue of Blood, Anand et al provide compelling evidence that resistance to Notch inhibitor therapy in early T-cell …
Integrated clinical genotype-phenotype characteristics of early T-cell precursor acute lymphoblastic leukemia.
Ye MT, Wang Y, Zuo Z, Calin S, He H, Tang Z, Jabbour EJ, Borthakur G, Zhang Y, Yang Y, You MJ. Ye MT, et al. Cancer. 2023 Jan 1;129(1):49-59. doi: 10.1002/cncr.34515. Epub 2022 Oct 25. Cancer. 2023. PMID: 36281717 Free article.
BACKGROUND: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of T-ALL with a unique immunophenotype and high treatment failure rate. ...TP53 mutation was the only molecular prognostic marker and w …
BACKGROUND: Early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) is a distinct subtype of …
Recent Advances in the Biology and Treatment of T Cell Acute Lymphoblastic Leukemia.
Hefazi M, Litzow MR. Hefazi M, et al. Curr Hematol Malig Rep. 2018 Aug;13(4):265-274. doi: 10.1007/s11899-018-0455-9. Curr Hematol Malig Rep. 2018. PMID: 29948644 Review.
PURPOSE OF REVIEW: This article provides an overview of the current knowledge regarding the biology and treatment of T cell acute lymphoblastic leukemia (T-ALL) and highlights the most recent findings in this field over the past 5 years. …
PURPOSE OF REVIEW: This article provides an overview of the current knowledge regarding the biology and treatment of T cell …
Recent developments in the management of T-cell precursor acute lymphoblastic leukemia/lymphoma.
Fielding AK, Banerjee L, Marks DI. Fielding AK, et al. Curr Hematol Malig Rep. 2012 Jun;7(2):160-9. doi: 10.1007/s11899-012-0123-4. Curr Hematol Malig Rep. 2012. PMID: 22476945 Review.
T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma are uncommon disorders classified together by the World Health Organization classification as "T-lymphoblastic leukemia/lymphoma." Th …
T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma are uncommon d …
High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response.
Remke M, Pfister S, Kox C, Toedt G, Becker N, Benner A, Werft W, Breit S, Liu S, Engel F, Wittmann A, Zimmermann M, Stanulla M, Schrappe M, Ludwig WD, Bartram CR, Radlwimmer B, Muckenthaler MU, Lichter P, Kulozik AE. Remke M, et al. Blood. 2009 Jul 30;114(5):1053-62. doi: 10.1182/blood-2008-10-186536. Epub 2009 Apr 30. Blood. 2009. PMID: 19406988 Free article.
Precursor T-cell acute lymphoblastic leukemia (T-ALL) in children represents a clinical challenge, because relapses are usually fatal. ...We show that DNA copy-number changes are common in T-ALL and affect 70 of 73 (96%) pat …
Precursor T-cell acute lymphoblastic leukemia (T-ALL) in children represents a clinical cha …
Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma.
Li S, Juco J, Mann KP, Holden JT. Li S, et al. Am J Clin Pathol. 2004 Feb;121(2):268-74. doi: 10.1309/K2FY-1TED-8GEG-FLNG. Am J Clin Pathol. 2004. PMID: 14983942
We compared the antigen expression profile of thymocytes in lymphocyte-rich thymoma with that of precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-cell ALL/LBL) cells using 4-colorflow cytometry. …
We compared the antigen expression profile of thymocytes in lymphocyte-rich thymoma with that of precursor T-cell ac …
Discriminant function analysis as decision support system for the diagnosis of acute leukemia with a minimal four color screening panel and multiparameter flow cytometry immunophenotyping.
Ratei R, Karawajew L, Lacombe F, Jagoda K, Del Poeta G, Kraan J, De Santiago M, Kappelmayer J, Björklund E, Ludwig WD, Gratama JW, Orfao A; European Working Group of Clinical Cell Analysis. Ratei R, et al. Leukemia. 2007 Jun;21(6):1204-11. doi: 10.1038/sj.leu.2404675. Epub 2007 Apr 5. Leukemia. 2007. PMID: 17410192
We determined the potential value of a minimal four-color combination panel of 13 monoclonal antibodies (mAbs) with a CD45/sideward light scatter-gating strategy for a standardized MFC immunophenotyping of the clinically most relevant subgroups of AL. Bone marrow samples from 155 …
We determined the potential value of a minimal four-color combination panel of 13 monoclonal antibodies (mAbs) with a CD45/sideward light sc …