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Low dose venetoclax as a single agent treatment of plasma cell malignancies harboring t(11;14).
Nahi H, Kashif M, Klimkowska M, Karvouni M, Wallblom A, Gran C, Hauenstein J, Frengen N, Gustafsson C, Afram G, Uttervall K, Lund J, Månsson R, Wagner AK, Alici E. Nahi H, et al. Am J Hematol. 2021 Aug 1;96(8):925-933. doi: 10.1002/ajh.26207. Epub 2021 May 18. Am J Hematol. 2021. PMID: 33901326 Free article.
Additionally, patient material from venetoclax non-treated group including non-t(11;14) diagnosis (n = 27), t(11;14) diagnosis (n = 17), t(11;14) relapse (n = 7), hyperdiploidy (n = 6) and hyperdiploidy + t(11;14) (n …
Additionally, patient material from venetoclax non-treated group including non-t(11;14) diagnosis (n = 27), t(11 …
Retinoic acid and acute promyelocytic leukemia: a model of targetting treatment for human cancer.
Chen Z, Chen SJ, Wang ZY. Chen Z, et al. C R Acad Sci III. 1994 Dec;317(12):1135-41. C R Acad Sci III. 1994. PMID: 7697468 Review.
PML/RAR alpha antagonizes wild-type PML and RXR and could block the differentiation pathways mediated by these two regulators. A variant translocation t(11;17) has also been discovered in a subset of APL which fuses RAR alpha to a new gene, PLZF on chromosome …
PML/RAR alpha antagonizes wild-type PML and RXR and could block the differentiation pathways mediated by these two regulators. A variant tra …
Clinical features and treatment outcomes of pediatric acute promyelocytic leukemia in a Mexican pediatric hospital.
Dorantes-Acosta E, Medina-Sanson A, Jaimes-García Y, López-Martínez B. Dorantes-Acosta E, et al. Rev Invest Clin. 2013 Sep-Oct;65(5):392-8. Rev Invest Clin. 2013. PMID: 24687338
In all cases, the diagnoses were made by aspirating bone marrow and evaluating the t(15:17) or t(11:17) transcript. In eight cases, the molecular biology-based diagnostics for the PLM-RARa transcript were positive, and they were negative in two …
In all cases, the diagnoses were made by aspirating bone marrow and evaluating the t(15:17) or t(11:17) t …
Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins.
Rego EM, He LZ, Warrell RP Jr, Wang ZG, Pandolfi PP. Rego EM, et al. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10173-8. doi: 10.1073/pnas.180290497. Proc Natl Acad Sci U S A. 2000. PMID: 10954752 Free PMC article.
Acute promyelocytic leukemia (APL) is associated with chromosomal translocations always involving the RARalpha gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes) in t(15;17) or t(11;17), respectively. APL …
Acute promyelocytic leukemia (APL) is associated with chromosomal translocations always involving the RARalpha gene, which variably fuses to …