Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages.
Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CN.
Dalli J, et al.
Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12232-12237. doi: 10.1073/pnas.1607003113. Epub 2016 Oct 6.
Proc Natl Acad Sci U S A. 2016.
PMID: 27791009
Free PMC article.
With human recombinant enzymes, primary cells, and enantiomerically pure compounds we found that the synthetic maresin epoxide intermediate 13S,14S-eMaR (13S,14S-epoxy- 4Z,7Z,9E,11E,16Z,19Z-docosahexaenoic acid) was converted to MCTR1 (13R-glutathionyl, 14S-hydroxy- …
With human recombinant enzymes, primary cells, and enantiomerically pure compounds we found that the synthetic maresin epoxide intermediate …