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Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T. Fujimaki T. J Child Neurol. 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. J Child Neurol. 2009. PMID: 19841431 Review.
Central nervous system germ cell tumors are neoplasms that affect children and young adults. They are subclassified into germinoma and nongerminomatous germ cell tumors. The latter include teratoma (mature teratoma, immature teratoma …
Central nervous system germ cell tumors are neoplasms that affect children and young adults. They are subclassified int …
Rare and challenging extra-axial brain lesions: CT and MRI findings with clinico-radiological differential diagnosis and pathological correlation.
Demir MK, Yapıcıer O, Onat E, Toktaş ZO, Akakın A, Urgun K, Kılıç T. Demir MK, et al. Diagn Interv Radiol. 2014 Sep-Oct;20(5):448-52. doi: 10.5152/dir.2014.14031. Diagn Interv Radiol. 2014. PMID: 25010368 Free PMC article. Review.
In this pictorial essay, we present rare and challenging extra-axial brain lesions including neuroenteric cyst, primary leptomeningeal melanomatosis, isolated dural neurosarcoidosis, intradiploic epidermoid cyst, ruptured dermoid cyst, intraventricular …
In this pictorial essay, we present rare and challenging extra-axial brain lesions including neuroenteric cyst, primary leptomeningea …
The treatment of cranial germ cell tumours.
Brandes AA, Pasetto LM, Monfardini S. Brandes AA, et al. Cancer Treat Rev. 2000 Aug;26(4):233-42. doi: 10.1053/ctrv.2000.0169. Cancer Treat Rev. 2000. PMID: 10913379 Review.
Germ cell tumours of the central nervous system (CNS) include many subtypes whose response to treatment varies, even though the symptoms and radiological appearances are similar. ...Patients with choriocarcinoma, embryonal carcinoma, or yolk sac tumour have t …
Germ cell tumours of the central nervous system (CNS) include many subtypes whose response to treatment varies, even th …
Indications for salvage surgery during treatment for intracranial germ cell tumors.
Kanamori M, Kumabe T, Watanabe M, Chonan M, Saito R, Yamashita Y, Ogawa Y, Sonoda Y, Tominaga T. Kanamori M, et al. J Neurooncol. 2018 Jul;138(3):601-607. doi: 10.1007/s11060-018-2827-3. Epub 2018 Mar 26. J Neurooncol. 2018. PMID: 29582270
Changes in tumor markers, histological findings, and the pattern of failure after salvage surgery were reviewed. Growing teratoma syndrome (GTS) is defined as enlargement of tumor consisting of mature teratoma after chemotherapy with normalization of tumor ma …
Changes in tumor markers, histological findings, and the pattern of failure after salvage surgery were reviewed. Growing teratoma syn …
Strategy of combined treatment of germ cell tumors.
Sawamura Y. Sawamura Y. Prog Neurol Surg. 2009;23:86-95. doi: 10.1159/000210055. Epub 2009 Mar 23. Prog Neurol Surg. 2009. PMID: 19329863 Review.
Pineal GCTs can be grossly divided into three categories: those with a good, intermediate, and poor prognostic. Germinoma and mature teratoma are curable and classified into the good prognostic group, whereas embryonal carcinoma, yolk sac tumor, and other highly mal …
Pineal GCTs can be grossly divided into three categories: those with a good, intermediate, and poor prognostic. Germinoma and mature …
Teratomas of the central nervous system: treatment considerations based on 34 cases.
Sawamura Y, Kato T, Ikeda J, Murata J, Tada M, Shirato H. Sawamura Y, et al. J Neurosurg. 1998 Nov;89(5):728-37. doi: 10.3171/jns.1998.89.5.0728. J Neurosurg. 1998. PMID: 9817409
OBJECT: The optimum clinical management of central nervous system (CNS) teratomas, particularly postsurgical adjuvant therapy, is still unclear, partly as a result of the tumors' low incidence. ...Four of these 27 patients died as a result of radical s …
OBJECT: The optimum clinical management of central nervous system (CNS) teratomas, particularly postsurgical adjuvant …
Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation.
Khatua S, Dhall G, O'Neil S, Jubran R, Villablanca JG, Marachelian A, Nastia A, Lavey R, Olch AJ, Gonzalez I, Gilles F, Nelson M, Panigrahy A, McComb G, Krieger M, Fan J, Sposto R, Finlay JL. Khatua S, et al. Pediatr Blood Cancer. 2010 Jul 15;55(1):42-6. doi: 10.1002/pbc.22468. Pediatr Blood Cancer. 2010. PMID: 20222020
BACKGROUND: The purpose of this study was to evaluate a reduced irradiation dose strategy for newly diagnosed primary central nervous system (CNS) germinomas. METHODS: Twenty patients with histologically diagnosed localized pure germinoma (n = 19) or germinom …
BACKGROUND: The purpose of this study was to evaluate a reduced irradiation dose strategy for newly diagnosed primary central nerv …
A review of soluble c-kit (s-kit) as a novel tumor marker and possible molecular target for the treatment of CNS germinoma.
Takeshima H, Kuratsu J. Takeshima H, et al. Surg Neurol. 2003 Oct;60(4):321-4; discussion 324-5. doi: 10.1016/s0090-3019(03)00430-0. Surg Neurol. 2003. PMID: 14505850 Review.
BACKGROUND: Although germinomas are the most common central nervous system (CNS) germ cell tumors (GCTs), no specific tumor marker(s) has been identified. ...RESULTS: On the cell surface of germinomas, c-kit was diffusely positive. Some mature terat …
BACKGROUND: Although germinomas are the most common central nervous system (CNS) germ cell tumors (GCTs), no specific t …
Management of malignant pineal germ cell tumors with residual mature teratoma.
Friedman JA, Lynch JJ, Buckner JC, Scheithauer BW, Raffel C. Friedman JA, et al. Neurosurgery. 2001 Mar;48(3):518-22; discussion 522-3. doi: 10.1097/00006123-200103000-00011. Neurosurgery. 2001. PMID: 11270541
RESULTS: All patients with residual pineal tumors underwent surgical resection via an infratentorial, supracerebellar approach. Pathological examination revealed mature teratoma in five patients and amorphous debris in one patient. ...CONCLUSION: Residual pineal tum …
RESULTS: All patients with residual pineal tumors underwent surgical resection via an infratentorial, supracerebellar approach. Pathological …
Is histological diagnosis necessary to start treatment for germ cell tumours in the pineal region?
Kanamori M, Kumabe T, Tominaga T. Kanamori M, et al. J Clin Neurosci. 2008 Sep;15(9):978-87. doi: 10.1016/j.jocn.2007.08.004. Epub 2008 Jul 9. J Clin Neurosci. 2008. PMID: 18617412
Forty-one patients were treated under a clinical diagnosis of pineal germ cell tumour using neoadjuvant chemotherapy and radiation therapy without histological verification. Of the 41 patients, 32 achieved an excellent response, whereas nine required the delayed resection …
Forty-one patients were treated under a clinical diagnosis of pineal germ cell tumour using neoadjuvant chemotherapy and radiation therap …
13 results