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Page 1
Molecular stratifications, biomarker candidates and new therapeutic options in current medulloblastoma treatment approaches.
Menyhárt O, Győrffy B. Menyhárt O, et al. Cancer Metastasis Rev. 2020 Mar;39(1):211-233. doi: 10.1007/s10555-020-09854-1. Cancer Metastasis Rev. 2020. PMID: 31970590 Free PMC article. Review.
Medulloblastoma (MB) is the most common malignant childhood tumor of the brain. Multimodal treatment consisting of surgery, radiation therapy, and chemotherapy reduced cumulative incidence of late mortality but increased the incidence of subsequent neoplasms …
Medulloblastoma (MB) is the most common malignant childhood tumor of the brain. Multimodal treatment consisting of surgery, radiation …
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P. Franceschi E, et al. Lancet Oncol. 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. Lancet Oncol. 2019. PMID: 31797797 Review.
Our recommendations are a resource for professionals involved in the management of post-pubertal and adult patients with medulloblastoma, for patients and caregivers, and for health-care providers in Europe. The implementation of this guideline requires multidisciplinary s …
Our recommendations are a resource for professionals involved in the management of post-pubertal and adult patients with medulloblastoma, fo …
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.
Donovan LK, Delaidelli A, Joseph SK, Bielamowicz K, Fousek K, Holgado BL, Manno A, Srikanthan D, Gad AZ, Van Ommeren R, Przelicki D, Richman C, Ramaswamy V, Daniels C, Pallota JG, Douglas T, Joynt ACM, Haapasalo J, Nor C, Vladoiu MC, Kuzan-Fischer CM, Garzia L, Mack SC, Varadharajan S, Baker ML, Hendrikse L, Ly M, Kharas K, Balin P, Wu X, Qin L, Huang N, Stucklin AG, Morrissy AS, Cavalli FMG, Luu B, Suarez R, De Antonellis P, Michealraj A, Rastan A, Hegde M, Komosa M, Sirbu O, Kumar SA, Abdullaev Z, Faria CC, Yip S, Hukin J, Tabori U, Hawkins C, Aldape K, Daugaard M, Maris JM, Sorensen PH, Ahmed N, Taylor MD. Donovan LK, et al. Nat Med. 2020 May;26(5):720-731. doi: 10.1038/s41591-020-0827-2. Epub 2020 Apr 27. Nat Med. 2020. PMID: 32341580 Free PMC article.
Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent medulloblastomas and posterior fossa group A (PFA) ependymomas are located adjacent to and bath …
Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently und …
Medulloblastoma: Molecular understanding, treatment evolution, and new developments.
Liu X, Ding C, Tan W, Zhang A. Liu X, et al. Pharmacol Ther. 2020 Jun;210:107516. doi: 10.1016/j.pharmthera.2020.107516. Epub 2020 Feb 24. Pharmacol Ther. 2020. PMID: 32105673 Review.
Medulloblastoma (MB) is the most common childhood malignant brain tumor, accounting for approximately 20% of all pediatric central nervous system tumors. ...More recent studies have indicated that up to seven molecular subgroups exist in childhood MB. Moreover, stud …
Medulloblastoma (MB) is the most common childhood malignant brain tumor, accounting for approximately 20% of all pediatric central ne …
Guide for paediatric radiotherapy procedures.
Laprie A, Bernier V, Padovani L, Martin V, Chargari C, Supiot S, Claude L. Laprie A, et al. Cancer Radiother. 2022 Feb-Apr;26(1-2):356-367. doi: 10.1016/j.canrad.2021.11.018. Epub 2021 Dec 27. Cancer Radiother. 2022. PMID: 34969622
The treatment guidelines follow the recommendations of the French society for childhood cancers (SFCE) or the French and European prospective protocols. ...The irradiation methods include all the techniques currently available: 3D conformational irradiation, intensity modu …
The treatment guidelines follow the recommendations of the French society for childhood cancers (SFCE) or the French and European pro …
Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile.
Sadighi Z, Vats T, Khatua S. Sadighi Z, et al. J Child Neurol. 2012 Oct;27(10):1302-7. doi: 10.1177/0883073812449690. Epub 2012 Jul 22. J Child Neurol. 2012. PMID: 22826514 Review.
Medulloblastoma is the most common malignant brain tumor of childhood, accounting for nearly 25% to 30% of primary central nervous system tumors in children younger than 18 years of age. ...This could now help to identify patients who might benefit from dose escalation and …
Medulloblastoma is the most common malignant brain tumor of childhood, accounting for nearly 25% to 30% of primary central nervous sy …
SHH inhibitors for the treatment of medulloblastoma.
Samkari A, White J, Packer R. Samkari A, et al. Expert Rev Neurother. 2015;15(7):763-70. doi: 10.1586/14737175.2015.1052796. Epub 2015 May 31. Expert Rev Neurother. 2015. PMID: 26027634 Review.
Medulloblastoma is the most common malignant brain tumor of childhood. It is currently stratified into four molecular variants through the advances in transcriptional profiling. ...
Medulloblastoma is the most common malignant brain tumor of childhood. It is currently stratified into four molecular variants throug …
Advances in the biology and treatment of pediatric central nervous system tumors.
Vitanza NA, Cho YJ. Vitanza NA, et al. Curr Opin Pediatr. 2016 Feb;28(1):34-9. doi: 10.1097/MOP.0000000000000309. Curr Opin Pediatr. 2016. PMID: 26709691 Review.
Here, we provide an update on insights gained through molecular profiling of the most common malignant childhood brain tumors. RECENT FINDINGS: Genomic profiling studies of medulloblastoma, ependymoma, and diffuse intrinsic pontine glioma (diffuse midline glioma, with H3-K …
Here, we provide an update on insights gained through molecular profiling of the most common malignant childhood brain tumors. RECENT …
How do we approach the management of medulloblastoma in young children?
Lafay-Cousin L, Baroni L, Ramaswamy V, Bouffet E. Lafay-Cousin L, et al. Pediatr Blood Cancer. 2022 Oct;69(10):e29838. doi: 10.1002/pbc.29838. Epub 2022 Jun 10. Pediatr Blood Cancer. 2022. PMID: 35686728
Therapeutic strategies avoiding craniospinal irradiation were developed for young children with medulloblastoma to improve survival while protecting the neurocognitive outcomes of these vulnerable patients. ...While recent clinical trials point toward more encouraging surv …
Therapeutic strategies avoiding craniospinal irradiation were developed for young children with medulloblastoma to improve survival w …
Neurological Complications of the Treatment of Pediatric Neoplastic Disorders.
Sun LR, Cooper S. Sun LR, et al. Pediatr Neurol. 2018 Aug;85:33-42. doi: 10.1016/j.pediatrneurol.2018.05.011. Epub 2018 Jun 2. Pediatr Neurol. 2018. PMID: 30126755 Review.
Neurological complications resulting from childhood cancer treatments are common. Treatment for childhood neoplastic disorders is often multimodal and may include procedures, cranial irradiation, chemotherapy, transplant, and immunotherapy, each of which carries dis …
Neurological complications resulting from childhood cancer treatments are common. Treatment for childhood neoplastic disorders …
84 results