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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1979 1
1982 2
1983 2
1984 3
1985 2
1986 3
1989 1
1992 2
1994 1
1996 1
1998 1
2000 1
2001 1
2002 2
2003 1
2004 3
2005 4
2006 5
2007 2
2008 5
2009 2
2010 1
2011 1
2012 4
2013 2
2014 3
2015 2
2016 6
2017 3
2018 3
2019 4
2020 3
2021 3
2024 1

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76 results

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Page 1
Benefit-Risk Assessment of Plecanatide in the Treatment of Chronic Idiopathic Constipation.
Miner PB Jr. Miner PB Jr. Drug Saf. 2019 May;42(5):603-615. doi: 10.1007/s40264-018-0781-9. Drug Saf. 2019. PMID: 30649746 Review.
Plecanatide, a uroguanylin analog, activates the guanylate cyclase C receptors in the epithelial lining of the gastrointestinal tract in a pH-dependent fashion initiating (1) the conversion of intracellular guanosine triphosphate to cyclic guanosine monophosphate, which …
Plecanatide, a uroguanylin analog, activates the guanylate cyclase C receptors in the epithelial lining of the gastrointestinal tract in a p …
Clinical protocol for the management of malignant hyperthermia.
Kollmann-Camaiora A, Alsina E, Domínguez A, Del Blanco B, Yepes MJ, Guerrero JL, García A. Kollmann-Camaiora A, et al. Rev Esp Anestesiol Reanim. 2017 Jan;64(1):32-40. doi: 10.1016/j.redar.2016.06.004. Epub 2016 Sep 12. Rev Esp Anestesiol Reanim. 2017. PMID: 27633384 Review. English, Spanish.
It is induced by an abnormal regulation of the ryanodine receptors, producing a massive release of calcium from the sarcoplasmic reticulum in the striate muscle. Clinical manifestations include: CO(2) increase, tachycardia, haemodynamic instability, metabolic and respirato …
It is induced by an abnormal regulation of the ryanodine receptors, producing a massive release of calcium from the sarcoplasmic reticulum i …
Hypophosphatemia: an evidence-based approach to its clinical consequences and management.
Amanzadeh J, Reilly RF Jr. Amanzadeh J, et al. Nat Clin Pract Nephrol. 2006 Mar;2(3):136-48. doi: 10.1038/ncpneph0124. Nat Clin Pract Nephrol. 2006. PMID: 16932412 Review.
The majority of this reabsorption (80%) occurs in the proximal tubule and is mediated by an isoform of the sodium-phosphate cotransporter (NaPi-II). Parathyroid hormone, via a variety of intracellular signaling cascades leading to NaPi-IIa internalization and downre …
The majority of this reabsorption (80%) occurs in the proximal tubule and is mediated by an isoform of the sodium-phosphate cotranspo …
Classification and Reporting of Potentially Proarrhythmic Common Genetic Variation in Long QT Syndrome Genetic Testing.
Giudicessi JR, Roden DM, Wilde AAM, Ackerman MJ. Giudicessi JR, et al. Circulation. 2018 Feb 6;137(6):619-630. doi: 10.1161/CIRCULATIONAHA.117.030142. Circulation. 2018. PMID: 29431662 Free PMC article. Review.
In turn, these molecular insights led to the development and increased utilization of clinically impactful genetic testing for congenital long QT syndrome. ...In this white paper, we examine the current classification and reporting (or lack thereof) of potentially proarrhy …
In turn, these molecular insights led to the development and increased utilization of clinically impactful genetic testing for congen …
Treatment of exertional rhabdomyolysis in athletes: a systematic review.
Manspeaker S, Henderson K, Riddle D. Manspeaker S, et al. JBI Database System Rev Implement Rep. 2016 Jun;14(6):117-47. doi: 10.11124/JBISRIR-2016-001879. JBI Database System Rev Implement Rep. 2016. PMID: 27532656 Review.
BACKGROUND: Exertional rhabdomyolysis (ER) is the breakdown of skeletal muscle tissue following intense physical activity that results in impairment of the cell membrane, which allows intracellular contents to be released into the bloodstream. Signs and symptoms include my …
BACKGROUND: Exertional rhabdomyolysis (ER) is the breakdown of skeletal muscle tissue following intense physical activity that results in im …
Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications.
Anderson G, Maes M. Anderson G, et al. Curr Top Med Chem. 2020;20(7):524-539. doi: 10.2174/1568026620666200131094445. Curr Top Med Chem. 2020. PMID: 32003689 Review.
Both orexin and melatonin positively regulate mitochondria oxidative phosphorylation. Consequently, gut-mediated increases in ceramide have impacts on the circadian rhythm and the circadian regulation of mitochondrial function. ...This has a number of treatment implication …
Both orexin and melatonin positively regulate mitochondria oxidative phosphorylation. Consequently, gut-mediated increases in ceramid …
New Therapeutic Approaches for the Treatment of Hyperkalemia in Patients Treated with Renin-Angiotensin-Aldosterone System Inhibitors.
Tamargo J, Caballero R, Delpón E. Tamargo J, et al. Cardiovasc Drugs Ther. 2018 Feb;32(1):99-119. doi: 10.1007/s10557-017-6767-5. Cardiovasc Drugs Ther. 2018. PMID: 29372448 Review.
Hyperkalemia (serum potassium > 5.5 mEq/L) is a common clinical problem in patients with chronic kidney disease, hypertension, diabetes, and heart failure. It can result from increased K(+) intake, impaired distribution between intracellular and extracellular spa …
Hyperkalemia (serum potassium > 5.5 mEq/L) is a common clinical problem in patients with chronic kidney disease, hypertension, diabetes, …
Treatment of acute metabolic acidosis: a pathophysiologic approach.
Kraut JA, Madias NE. Kraut JA, et al. Nat Rev Nephrol. 2012 Oct;8(10):589-601. doi: 10.1038/nrneph.2012.186. Epub 2012 Sep 4. Nat Rev Nephrol. 2012. PMID: 22945490 Review.
Calculation of the serum anion gap and the change from baseline enables the physician to detect organic acidoses, a common cause of severe metabolic acidosis, and aids therapeutic decisions. A fall in extracellular and intracellular pH can affect cellular function v …
Calculation of the serum anion gap and the change from baseline enables the physician to detect organic acidoses, a common cause of severe m …
Telomere and microtubule targeting in treatment-sensitive and treatment-resistant human prostate cancer cells.
Zhang B, Suer S, Livak F, Adediran S, Vemula A, Khan MA, Ning Y, Hussain A. Zhang B, et al. Mol Pharmacol. 2012 Aug;82(2):310-21. doi: 10.1124/mol.111.076752. Epub 2012 May 14. Mol Pharmacol. 2012. PMID: 22584221
Telomere dynamics and the effects of targeting telomeres with sodium meta-arsenite (KML001) (an agent undergoing early clinical trials), including combinations with paclitaxel and docetaxel, were evaluated in parental and drug-resistant cells. ...Wild-type DU145 cells have …
Telomere dynamics and the effects of targeting telomeres with sodium meta-arsenite (KML001) (an agent undergoing early clinical trial …
Risk Stratification in Patients With Nonisquemic Dilated Cardiomyopathy. The Role of Genetic Testing.
Peña-Peña ML, Monserrat L. Peña-Peña ML, et al. Rev Esp Cardiol (Engl Ed). 2019 Apr;72(4):333-340. doi: 10.1016/j.rec.2018.10.017. Epub 2019 Feb 18. Rev Esp Cardiol (Engl Ed). 2019. PMID: 30792015 English, Spanish.
More than 90 genes have been associated with this disease, which is one of the main causes of heart transplant and has been associated with an increased risk of sudden cardiac death. Risk stratification in these patients continues to be challenging. ...Genetic study often …
More than 90 genes have been associated with this disease, which is one of the main causes of heart transplant and has been associated with …
76 results