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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1942 1
1970 1
1974 1
1980 1
1985 1
1986 7
1987 12
1988 22
1989 30
1990 30
1991 43
1992 28
1993 25
1994 25
1995 20
1996 23
1997 35
1998 43
1999 27
2000 46
2001 56
2002 55
2003 55
2004 66
2005 85
2006 76
2007 82
2008 80
2009 77
2010 81
2011 89
2012 112
2013 127
2014 199
2015 196
2016 199
2017 177
2018 202
2019 219
2020 227
2021 197
2022 156
2023 152
2024 88

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3,191 results

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Page 1
Strategy for Treatment of Infected Diabetic Foot Ulcers.
Chang M, Nguyen TT. Chang M, et al. Acc Chem Res. 2021 Mar 2;54(5):1080-1093. doi: 10.1021/acs.accounts.0c00864. Epub 2021 Feb 17. Acc Chem Res. 2021. PMID: 33596041 Review.
Lead optimization of the thiirane class of inhibitors led to the discovery of (R)-ND-336, a potent (19 nM) and selective (450-fold) MMP-9 inhibitor. (R)-ND-336 accelerated wound healing in diabetic mice by decreasing ROS and NF-kappaB, lowering inflammation, and increasing …
Lead optimization of the thiirane class of inhibitors led to the discovery of (R)-ND-336, a potent (19 nM) and selective (450-fold) MMP-9 in …
In vivo tumor growth of high-grade serous ovarian cancer cell lines.
Mitra AK, Davis DA, Tomar S, Roy L, Gurler H, Xie J, Lantvit DD, Cardenas H, Fang F, Liu Y, Loughran E, Yang J, Sharon Stack M, Emerson RE, Cowden Dahl KD, V Barbolina M, Nephew KP, Matei D, Burdette JE. Mitra AK, et al. Gynecol Oncol. 2015 Aug;138(2):372-7. doi: 10.1016/j.ygyno.2015.05.040. Epub 2015 Jun 5. Gynecol Oncol. 2015. PMID: 26050922 Free PMC article.
However, OC lines that appear to genomically resemble HGSOC have not been extensively used and their growth characteristics in murine xenografts are essentially unknown. METHODS: To better understand growth patterns and characteristics of HGSOC cell lines in vivo …
However, OC lines that appear to genomically resemble HGSOC have not been extensively used and their growth characteristics in murine …
The oxadiazole antibacterials.
Janardhanan J, Chang M, Mobashery S. Janardhanan J, et al. Curr Opin Microbiol. 2016 Oct;33:13-17. doi: 10.1016/j.mib.2016.05.009. Epub 2016 May 27. Curr Opin Microbiol. 2016. PMID: 27239942 Free PMC article. Review.
These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). They show in vivo efficacy in murine models of peritonitis/sepsis and neutr …
These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) a …
Limitations of a morphological criterion of adaptive inference in the fossil record.
Ravosa MJ, Menegaz RA, Scott JE, Daegling DJ, McAbee KR. Ravosa MJ, et al. Biol Rev Camb Philos Soc. 2016 Nov;91(4):883-898. doi: 10.1111/brv.12199. Epub 2015 Jun 5. Biol Rev Camb Philos Soc. 2016. PMID: 26052620 Free article. Review.
Diet-related variation in loading magnitude and frequency induce a cascade of changes at the gross, tissue, cellular, protein and genetic levels, with such modelling and remodelling maintaining the integrity of oral structures vis-a-vis routine masticatory stresses. Ongoing integ …
Diet-related variation in loading magnitude and frequency induce a cascade of changes at the gross, tissue, cellular, protein and genetic le …
Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds.
Moraski GC, Deboosère N, Marshall KL, Weaver HA, Vandeputte A, Hastings C, Woolhiser L, Lenaerts AJ, Brodin P, Miller MJ. Moraski GC, et al. PLoS One. 2020 Jan 6;15(1):e0227224. doi: 10.1371/journal.pone.0227224. eCollection 2020. PLoS One. 2020. PMID: 31905374 Free PMC article.
The in vitro ADME properties (protein binding, CaCo-2, human microsomal stability and CYP450 inhibition) were determined for an outstanding compound of the series, ND-11543. ND-11543 was tolerable at >500 mg/kg in mice and at a dose of 200 mg/kg displayed good drug expo …
The in vitro ADME properties (protein binding, CaCo-2, human microsomal stability and CYP450 inhibition) were determined for an outstanding …
Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer.
Zhao D, Cai L, Lu X, Liang X, Li J, Chen P, Ittmann M, Shang X, Jiang S, Li H, Meng C, Flores I, Song JH, Horner JW, Lan Z, Wu CJ, Li J, Chang Q, Chen KC, Wang G, Deng P, Spring DJ, Wang YA, DePinho RA. Zhao D, et al. Cancer Discov. 2020 Sep;10(9):1374-1387. doi: 10.1158/2159-8290.CD-19-1352. Epub 2020 May 8. Cancer Discov. 2020. PMID: 32385075 Free PMC article.
We previously identified CHD1 as an essential gene in PTEN-deficient cancer cells. Here, we sought definitive in vivo genetic evidence for, and mechanistic understanding of, the essential role of CHD1 in PTEN-deficient prostate cancer. In Pten and Pten/Smad4 genetic …
We previously identified CHD1 as an essential gene in PTEN-deficient cancer cells. Here, we sought definitive in vivo genetic …
A dysmorphic mouse model reveals developmental interactions of chondrocranium and dermatocranium.
Motch Perrine SM, Pitirri MK, Durham EL, Kawasaki M, Zheng H, Chen DZ, Kawasaki K, Richtsmeier JT. Motch Perrine SM, et al. Elife. 2022 Jun 15;11:e76653. doi: 10.7554/eLife.76653. Elife. 2022. PMID: 35704354 Free PMC article.
We evaluate the embryonic mouse chondrocranium and dermatocranium in 3D, and delineate the effects of a Fgfr2 variant on embryonic chondrocranial cartilages and on their association with forming dermal bones using the Fgfr2c(C342Y/+) Crouzon syndrome mouse. ...The c …
We evaluate the embryonic mouse chondrocranium and dermatocranium in 3D, and delineate the effects of a Fgfr2 variant on embryonic ch …
Generation and characterization of a plasminogen-binding group A streptococcal M-protein/streptokinase-sensitive mouse line.
Ayinuola YA, Donahue DL, Charles J, Liang Z, Castellino FJ, Ploplis VA. Ayinuola YA, et al. J Thromb Haemost. 2023 Jun;21(6):1630-1635. doi: 10.1016/j.jtha.2023.02.028. Epub 2023 Mar 11. J Thromb Haemost. 2023. PMID: 36914052 Free article.
Binding to Pg and its activation are dictated by selected sequences within the human host Pg protein, making it difficult to generate animal models to study this pathogen. OBJECTIVES: To develop a murine model for studying GAS infection by minimally modifying mou …
Binding to Pg and its activation are dictated by selected sequences within the human host Pg protein, making it difficult to generate ani …
Noninvasive measurement of mucosal immunity in a free-ranging baboon population.
Gesquiere LR, Habig B, Hansen C, Li A, Freid K, Learn NH, Alberts SC, Graham AL, Archie EA. Gesquiere LR, et al. Am J Primatol. 2020 Feb;82(2):e23093. doi: 10.1002/ajp.23093. Epub 2020 Jan 13. Am J Primatol. 2020. PMID: 31930746 Free PMC article.
Ecoimmunological patterns and processes remain understudied in wild primates, in part because of the lack of noninvasive methods to measure immunity. ...Here we validated a commercial ELISA kit to measure fecal IgA in baboons, tested the robustness of its results to …
Ecoimmunological patterns and processes remain understudied in wild primates, in part because of the lack of noninvasive methods to m …
In vivo X-ray computed tomographic imaging of soft tissue with native, intravenous, or oral contrast.
Wathen CA, Foje N, van Avermaete T, Miramontes B, Chapaman SE, Sasser TA, Kannan R, Gerstler S, Leevy WM. Wathen CA, et al. Sensors (Basel). 2013 May 27;13(6):6957-80. doi: 10.3390/s130606957. Sensors (Basel). 2013. PMID: 23711461 Free PMC article. Review.
Here we review the strategies available to visualize lung, fat, brain, kidney, liver, spleen, vasculature, gastrointestinal tract, and liver tissues of living mice using either innate contrast, or commercial injectable or ingestible agents with selective perfusion. Further …
Here we review the strategies available to visualize lung, fat, brain, kidney, liver, spleen, vasculature, gastrointestinal tract, and liver …
3,191 results