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1968 1
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1980 4
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1982 4
1983 5
1984 2
1985 5
1986 6
1987 2
1988 4
1989 7
1990 4
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1993 4
1994 8
1995 4
1996 2
1997 6
1998 7
1999 3
2000 9
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2002 19
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2005 39
2006 44
2007 59
2008 53
2009 70
2010 78
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2012 91
2013 109
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2016 95
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2024 40

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1,685 results

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Page 1
Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases.
Vrba J, Papoušková B, Lněničková K, Kosina P, Křen V, Ulrichová J. Vrba J, et al. Antioxidants (Basel). 2021 Jun 14;10(6):954. doi: 10.3390/antiox10060954. Antioxidants (Basel). 2021. PMID: 34198653 Free PMC article.
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of the natural flavonolignans silybin A and silybin B, respectively. ...Furthermore, we found that recombinant human UGTs 1A1, 1 …
2,3-Dehydrosilybin A and 2,3-dehydrosilybin B are a pair of enantiomers formed by the oxidation of …
2,3-Dehydrosilybin A/B as a pro-longevity and anti-aggregation compound.
Filippopoulou K, Papaevgeniou N, Lefaki M, Paraskevopoulou A, Biedermann D, Křen V, Chondrogianni N. Filippopoulou K, et al. Free Radic Biol Med. 2017 Feb;103:256-267. doi: 10.1016/j.freeradbiomed.2016.12.042. Epub 2016 Dec 28. Free Radic Biol Med. 2017. PMID: 28039083
As a consequence, the identification of compounds, preferably natural-occurring, administered through diet, with lifespan-extending, anti-aggregation and anti-oxidation properties that in parallel exhibit negligible side-effects is the main goal in the battle against aging. Here …
As a consequence, the identification of compounds, preferably natural-occurring, administered through diet, with lifespan-extending, anti-ag …
In vitro study of 2,3-dehydrosilybin and its galloyl esters as potential inhibitors of angiogenesis.
Pivodová V, Zahler S, Karas D, Valentová K, Ulrichova J. Pivodová V, et al. Pharmazie. 2016 Aug 1;71(8):478-483. doi: 10.1691/ph.2016.6579. Pharmazie. 2016. PMID: 29442036
2,3-Dehydrosilybin exhibits substantial anticancer and antiangiogenic effects, which can be potentially improved by semi-synthetic modification such as esterification with gallic acid. The aim of this study was to examine the potential antiangiogenic effect o …
2,3-Dehydrosilybin exhibits substantial anticancer and antiangiogenic effects, which can be potentially improved by sem …
Silybin and 2,3-Dehydrosilybin Flavonolignans as Free Radical Scavengers.
Reina M, Martínez A. Reina M, et al. J Phys Chem B. 2015 Sep 3;119(35):11597-606. doi: 10.1021/acs.jpcb.5b06448. Epub 2015 Aug 19. J Phys Chem B. 2015. PMID: 26259041
These spectra may be useful for monitoring the oxidation between silybin and 2,3-dehydrosilybin, thus providing important experimental information. The relative abundance of deprotonated species under physiological conditions is also reported. Under ph …
These spectra may be useful for monitoring the oxidation between silybin and 2,3-dehydrosilybin, thus providing …
Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells.
Karas D, Gažák R, Valentová K, Chambers CS, Pivodová V, Biedermann D, Křenková A, Oborná I, Kuzma M, Cvačka J, Ulrichová J, Křen V. Karas D, et al. J Nat Prod. 2016 Apr 22;79(4):812-20. doi: 10.1021/acs.jnatprod.5b00905. Epub 2016 Mar 25. J Nat Prod. 2016. PMID: 27015547
The effects in vitro of 2,3-dehydrosilybin and several galloyl esters and methyl ethers on the viability, proliferation, and migration of human umbilical vein endothelial cells (HUVECs) were evaluated. The monogalloyl esters were synthesized by a chemoselecti …
The effects in vitro of 2,3-dehydrosilybin and several galloyl esters and methyl ethers on the viability, proliferation …
Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases.
Abenavoli L, Izzo AA, Milić N, Cicala C, Santini A, Capasso R. Abenavoli L, et al. Phytother Res. 2018 Nov;32(11):2202-2213. doi: 10.1002/ptr.6171. Epub 2018 Aug 6. Phytother Res. 2018. PMID: 30080294 Review.
MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main component. This article reviews the chemistry of MT, the pharmacokinetics and bioavailability, the pharmacologically relevant actions for liver dise …
MT fruits contain a mixture of flavonolignans collectively known as silymarin, being silybin (also named silibinin) the main componen …
Chemo-enzymatic synthesis of silybin and 2,3-dehydrosilybin dimers.
Vavříková E, Vacek J, Valentová K, Marhol P, Ulrichová J, Kuzma M, Křen V. Vavříková E, et al. Molecules. 2014 Apr 2;19(4):4115-34. doi: 10.3390/molecules19044115. Molecules. 2014. PMID: 24699152 Free PMC article.
Here we present enzymatically and chemically prepared dimers of the flavonolignans silybin and 2,3-dehydrosilybin. Their electrochemical behavior was studied by in situ and ex situ square wave voltammetry. ...A 1,1-diphenyl-2-picrylhydrazyl (DPPH) and …
Here we present enzymatically and chemically prepared dimers of the flavonolignans silybin and 2,3-dehydrosilybin …
Oxidation of Natural Bioactive Flavonolignan 2,3-Dehydrosilybin: An Electrochemical and Spectral Study.
Sokolová R, Kocábová J, Marhol P, Fiedler J, Biedermann D, Vacek J, Křen V. Sokolová R, et al. J Phys Chem B. 2017 Jul 20;121(28):6841-6846. doi: 10.1021/acs.jpcb.7b04651. Epub 2017 Jul 11. J Phys Chem B. 2017. PMID: 28654289
The electrochemical oxidation of the natural antioxidant 2,3-dehydrosilybin (DHS) was investigated in acetonitrile. The spectral changes during two electron and two proton oxidation registered by in situ IR spectroelectrochemistry show that the electron trans …
The electrochemical oxidation of the natural antioxidant 2,3-dehydrosilybin (DHS) was investigated in acetonitrile. The …
New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity.
Dzubák P, Hajdúch M, Gazák R, Svobodová A, Psotová J, Walterová D, Sedmera P, Kren V. Dzubák P, et al. Bioorg Med Chem. 2006 Jun 1;14(11):3793-810. doi: 10.1016/j.bmc.2006.01.035. Epub 2006 Feb 8. Bioorg Med Chem. 2006. PMID: 16466920
Large series of O-alkyl derivatives (methyl and benzyl) of silybin and 2,3-dehydrosilybin was prepared. Selective alkylation of the silybin molecule was systematically investigated. ...Another group of 2,3-dehydrosilybin der …
Large series of O-alkyl derivatives (methyl and benzyl) of silybin and 2,3-dehydrosilybin was prepared. Selectiv …
Induction of apoptosis by 2,3-dehydrosilybin via a caspase-dependent pathway in human HeLa cells.
Cho BO, So Y, Jin CH, Byun MW, Seo KI, Ko K, Chun MS, Jeong IY. Cho BO, et al. Biosci Biotechnol Biochem. 2014;78(2):255-62. doi: 10.1080/09168451.2014.885828. Epub 2014 Apr 14. Biosci Biotechnol Biochem. 2014. PMID: 25036678
The aim of this study was to investigate the mechanisms involved in the apoptosis of HeLa cells due to 2,3-dehydrosilybin (DHS) treatment. DHS treatment over 24 h significantly inhibited cell viability and induced apoptosis in a dose-dependent manner. ...
The aim of this study was to investigate the mechanisms involved in the apoptosis of HeLa cells due to 2,3-dehydrosilybin …
1,685 results