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1988 17
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2008 18
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636 results

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Page 1
2,5-hexanedione-induced testicular injury.
Boekelheide K, Fleming SL, Allio T, Embree-Ku ME, Hall SJ, Johnson KJ, Kwon EJ, Patel SR, Rasoulpour RJ, Schoenfeld HA, Thompson S. Boekelheide K, et al. Annu Rev Pharmacol Toxicol. 2003;43:125-47. doi: 10.1146/annurev.pharmtox.43.100901.135930. Epub 2002 Jan 10. Annu Rev Pharmacol Toxicol. 2003. PMID: 12471174 Review.
Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is a well-studied model with a rich database. ...
Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is …
One-Pot Conversion of Cellulose into 2,5-Hexanedione in H(2)O-Tetrahydrofuran Co-Solvents.
Shi N, Zhu T, Zhang H, Huang H, Zhou L, Liu Y, Shu R. Shi N, et al. ACS Omega. 2023 Mar 14;8(12):11574-11582. doi: 10.1021/acsomega.3c00708. eCollection 2023 Mar 28. ACS Omega. 2023. PMID: 37008153 Free PMC article.
Catalytic conversion of cellulose into the novel platform molecule 2,5-hexanedione (HXD) is regarded as one feasible approach for high-value utilization of biomass resources. ...
Catalytic conversion of cellulose into the novel platform molecule 2,5-hexanedione (HXD) is regarded as one feasible ap …
The Wnt/beta-catenin pathway is involved in 2,5-hexanedione-induced ovarian granulosa cell cycle arrest.
Xu X, Pan Y, Zhan L, Sun Y, Chen S, Zhu J, Luo L, Zhang W, Li Y. Xu X, et al. Ecotoxicol Environ Saf. 2023 Dec;268:115720. doi: 10.1016/j.ecoenv.2023.115720. Epub 2023 Nov 22. Ecotoxicol Environ Saf. 2023. PMID: 37995618 Free article.
N-Hexane causes significant ovarian toxicity, and its main active metabolite 2,5-hexanedione (2,5-HD) can induce ovarian injury through mechanisms such as inducing apoptosis in ovarian granulosa cells (GCs); however, the specific mechanism has not been fully …
N-Hexane causes significant ovarian toxicity, and its main active metabolite 2,5-hexanedione (2,5-HD) can induce ovaria …
Mitophagy-dependent mitochondrial ROS mediates 2,5-hexanedione-induced NLRP3 inflammasome activation in BV2 microglia.
Wang W, Chang R, Wang Y, Hou L, Wang Q. Wang W, et al. Neurotoxicology. 2023 Dec;99:50-58. doi: 10.1016/j.neuro.2023.09.008. Epub 2023 Sep 16. Neurotoxicology. 2023. PMID: 37722613
However, the mechanisms of how the activation of NLRP3 inflammasome was triggered by 2,5-hexanedione (HD), the toxic product of n-hexane metabolism, remain to be explored. ...
However, the mechanisms of how the activation of NLRP3 inflammasome was triggered by 2,5-hexanedione (HD), the toxic pr …
Biochemical and physiological aspects of 2,5-hexanedione: endogenous or exogenous product?
Perbellini L, Pezzoli G, Brugnone F, Canesi M. Perbellini L, et al. Int Arch Occup Environ Health. 1993;65(1):49-52. doi: 10.1007/BF00586058. Int Arch Occup Environ Health. 1993. PMID: 8354575
This article reports results regarding two different physiological aspects of 2,5-hexanedione (2,5-HD). The first is the relationship between "free" 2,5-HD (the fraction of "real" 2,5-HD) and "total" 2,5-HD (2,5-HD obtained from acid hydrolysis) in urine and …
This article reports results regarding two different physiological aspects of 2,5-hexanedione (2,5-HD). The first is th …
2,5-Hexanedione increases the percentage of proliferative Sox2(+) cells in rat hippocampus.
Wang L, Liu S, Su D, Chen F, Lei T, Chen H, Dong W, Jiang Y, Sun X, Sun W. Wang L, et al. Toxicol Ind Health. 2018 Sep;34(9):589-595. doi: 10.1177/0748233718772767. Epub 2018 May 15. Toxicol Ind Health. 2018. PMID: 29764313
n-Hexane is an organic solvent widely used in industry. 2,5-Hexanedione (2,5-HD), the major neurotoxic metabolite of n-hexane, decreases the levels of neurofilaments (NFs) in neurons. ...
n-Hexane is an organic solvent widely used in industry. 2,5-Hexanedione (2,5-HD), the major neurotoxic metabolite of n- …
Proapoptotic effects of 2,5-hexanedione on pheochromocytoma cells via oxidative injury.
Qi B, Xu S, Liang Y, Wang J, Zhang Z, Li J, Zhou J. Qi B, et al. Mol Med Rep. 2019 Oct;20(4):3249-3255. doi: 10.3892/mmr.2019.10546. Epub 2019 Aug 1. Mol Med Rep. 2019. PMID: 31432125 Free PMC article.
Central and peripheral neuropathies induced by n-hexane exposure are a major health concern. 2,5-Hexanedione (2,5-HD) is the most significant neurotoxic metabolite of n-hexane; however, little is known regarding the underlying mechanism of its neurotoxicity. …
Central and peripheral neuropathies induced by n-hexane exposure are a major health concern. 2,5-Hexanedione (2,5-HD) i …
Effects of 2,5-hexanedione on angiogenesis and vasculogenesis in chick embryos.
Cheng X, Luo R, Wang G, Xu CJ, Feng X, Yang RH, Ding E, He YQ, Chuai M, Lee KK, Yang X. Cheng X, et al. Reprod Toxicol. 2015 Jan;51:79-89. doi: 10.1016/j.reprotox.2014.12.006. Epub 2014 Dec 27. Reprod Toxicol. 2015. PMID: 25549948
n-Hexane is widely used in industry and its metabolite, 2,5-hexanedione (2,5-HD), has been implicated as a neural toxin in the developing fetus. ...
n-Hexane is widely used in industry and its metabolite, 2,5-hexanedione (2,5-HD), has been implicated as a neural toxin …
2,5-Hexanedione Affects Ovarian Granulosa Cells in Swine by Regulating the CDKN1A Gene: A Transcriptome Analysis.
Chen Y, Kong C, Yang M, Liu Y, Han Z, Xu L, Zheng X, Ding Y, Yin Z, Zhang X. Chen Y, et al. Vet Sci. 2023 Mar 7;10(3):201. doi: 10.3390/vetsci10030201. Vet Sci. 2023. PMID: 36977240 Free PMC article.
N-hexane, a common industrial organic solvent, causes multiple organ damage owing to its metabolite, 2,5-hexanedione (2,5-HD). To identify and evaluate the effects of 2,5-HD on sows' reproductive performance, we used porcine ovarian granulosa cells (pGCs) as …
N-hexane, a common industrial organic solvent, causes multiple organ damage owing to its metabolite, 2,5-hexanedione (2 …
Determination of total urinary 2,5-hexanedione in the Chinese general population.
Xing-Fu P, Ya-Ling Q, Wei Z, Hong-Fang T, Zheng R, Bang-Hua W, Han-Lin H, Yu-Xin Z, Hui-Fang Y. Xing-Fu P, et al. Environ Res. 2016 Oct;150:645-650. doi: 10.1016/j.envres.2016.05.030. Epub 2016 May 26. Environ Res. 2016. PMID: 27237929
OBJECTIVE: Determination of the urinary levels of 2.5-hexanedione (2,5-HD) was performed in subjects belonging to the Chinese general population to define the reference value for this metabolite. ...
OBJECTIVE: Determination of the urinary levels of 2.5-hexanedione (2,5-HD) was performed in subjects belonging to the C …
636 results