Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1.
Il'ina IV, Dyrkheeva NS, Zakharenko AL, Sidorenko AY, Li-Zhulanov NS, Korchagina DV, Chand R, Ayine-Tora DM, Chepanova AA, Zakharova OD, Ilina ES, Reynisson J, Malakhova AA, Medvedev SP, Zakian SM, Volcho KP, Salakhutdinov NF, Lavrik OI.
Il'ina IV, et al.
Molecules. 2020 Jul 31;25(15):3496. doi: 10.3390/molecules25153496.
Molecules. 2020.
PMID: 32751997
Free PMC article.
These monoterpene-derived compounds were synthesized through preliminary isomerization of (+)-3-carene to (+)-2-carene followed by reaction with heteroaromatic aldehydes. All the compounds inhibit the TDP1 enzyme at micro- and submicromolar levels, with the most pot …
These monoterpene-derived compounds were synthesized through preliminary isomerization of (+)-3-carene to (+)-2-carene followe …