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Functional characterization of a Plagiochasma appendiculatum flavone synthase I showing flavanone 2-hydroxylase activity.
Han XJ, Wu YF, Gao S, Yu HN, Xu RX, Lou HX, Cheng AX. Han XJ, et al. FEBS Lett. 2014 Jun 27;588(14):2307-14. doi: 10.1016/j.febslet.2014.05.023. Epub 2014 May 22. FEBS Lett. 2014. PMID: 24859082 Free article.
The recombinant protein exhibited high FNS I activity catalyzing the conversion of naringenin to apigenin and 2-hydroxynaringenin. The critical residue for flavanone-2-hydroxylation activity was Tyr240, as identified from homology modeling and site-directed mutagene …
The recombinant protein exhibited high FNS I activity catalyzing the conversion of naringenin to apigenin and 2-hydroxynaringenin …
Enzymatic basis for stepwise C-glycosylation in the formation of flavonoid di-C-glycosides in sacred lotus (Nelumbo nucifera Gaertn.).
Feng CY, Li SS, Taguchi G, Wu Q, Yin DD, Gu ZY, Wu J, Xu WZ, Liu C, Wang LS. Feng CY, et al. Plant J. 2021 Apr;106(2):351-365. doi: 10.1111/tpj.15168. Epub 2021 Apr 5. Plant J. 2021. PMID: 33486798 Free article.
Recombinant UGT708N1 and UGT708N2 can C-glycosylate 2-hydroxyflavanones and 2-hydroxynaringenin C-glucoside, forming flavone mono-C-glycosides and di-C-glycosides, respectively, after dehydration. ...Finally, enzyme assays using cell-free extracts of lotus plumule s …
Recombinant UGT708N1 and UGT708N2 can C-glycosylate 2-hydroxyflavanones and 2-hydroxynaringenin C-glucoside, forming flavone m …
Stilbenes and flavonoids from Artocarpus nitidus subsp. lingnanensis.
Ti H, Wu P, Lin L, Wei X. Ti H, et al. Fitoterapia. 2011 Jun;82(4):662-5. doi: 10.1016/j.fitote.2011.02.001. Epub 2011 Feb 18. Fitoterapia. 2011. PMID: 21316425
The first stilbene possessing a gamma-aminobutyric acid lactam function, artocarpene (1), and a new flavanone, 2-hydroxynaringenin 4'-O-beta-d-glucopyranoside (2), were isolated from the stems of Artocarpus nitidus subsp. lingnanensis along with four known compounds …
The first stilbene possessing a gamma-aminobutyric acid lactam function, artocarpene (1), and a new flavanone, 2-hydroxynaringenin …
Biosynthesis and antifungal activity of fungus-induced O-methylated flavonoids in maize.
Förster C, Handrick V, Ding Y, Nakamura Y, Paetz C, Schneider B, Castro-Falcón G, Hughes CC, Luck K, Poosapati S, Kunert G, Huffaker A, Gershenzon J, Schmelz EA, Köllner TG. Förster C, et al. Plant Physiol. 2022 Jan 20;188(1):167-190. doi: 10.1093/plphys/kiab496. Plant Physiol. 2022. PMID: 34718797 Free PMC article.
The predominant end products were identified as two tautomers of a 2-hydroxynaringenin-derived compound termed xilonenin, which significantly inhibited the growth of two maize pathogens, Fusarium graminearum and Fusarium verticillioides. ...
The predominant end products were identified as two tautomers of a 2-hydroxynaringenin-derived compound termed xilonenin, whic …
Functional analysis of a novel C-glycosyltransferase in the orchid Dendrobium catenatum.
Ren Z, Ji X, Jiao Z, Luo Y, Zhang GQ, Tao S, Lei Z, Zhang J, Wang Y, Liu ZJ, Wei G. Ren Z, et al. Hortic Res. 2020 Jul 1;7:111. doi: 10.1038/s41438-020-0330-4. eCollection 2020. Hortic Res. 2020. PMID: 32637139 Free PMC article.
DcaCGT could specifically catalyze not only di-C-glycosylation but also O-glycosylation. Apart from the normal function of catalyzing 2-hydroxynaringenin and phloretin to the respective di-C-glycosides, DcaCGT also catalyzes apigenin to cosmosiin. Targeted metabolic …
DcaCGT could specifically catalyze not only di-C-glycosylation but also O-glycosylation. Apart from the normal function of catalyzing 2 …
Flavanone 8-dimethylallyltransferase in Sophora flavescens cell suspension cultures.
Yamamoto H, Senda M, Inoue K. Yamamoto H, et al. Phytochemistry. 2000 Aug;54(7):649-55. doi: 10.1016/s0031-9422(00)00198-9. Phytochemistry. 2000. PMID: 10975499
The microsomal fraction prenylated several other flavanones at the C-8 position less effectively as compared with naringenin. Interestingly, when 2'-hydroxynaringenin was used as a prenyl acceptor, the 8-lavandulyl (sophoraflavanone G) and the 6-dimethylallyl deriva …
The microsomal fraction prenylated several other flavanones at the C-8 position less effectively as compared with naringenin. Interestingly, …
A highly selective C-rhamnosyltransferase from Viola tricolor and insights into its mechanisms.
Han BY, Wang ZL, Li J, Jin Q, Wang HT, Chen K, Yi Y, Ågren H, Qiao X, Ye M. Han BY, et al. Acta Pharm Sin B. 2023 Aug;13(8):3535-3544. doi: 10.1016/j.apsb.2023.05.011. Epub 2023 May 16. Acta Pharm Sin B. 2023. PMID: 37655315 Free PMC article.
Herein, we report the first selective C-rhamnosyltransferase VtCGTc from the medicinal plant Viola tricolor. VtCGTc could efficiently catalyze C-rhamnosylation of 2-hydroxynaringenin 3-C-glucoside, and exhibited high selectivity towards UDP-Rha. ...
Herein, we report the first selective C-rhamnosyltransferase VtCGTc from the medicinal plant Viola tricolor. VtCGTc could efficiently cataly …
De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activity.
Marín L, Gutiérrez-Del-Río I, Villar CJ, Lombó F. Marín L, et al. Microb Biotechnol. 2021 Sep;14(5):2009-2024. doi: 10.1111/1751-7915.13874. Epub 2021 Jul 3. Microb Biotechnol. 2021. PMID: 34216097 Free PMC article.
It turned out that the heterologous flavanone 3-hydroxylase (F3H) has a 2-hydroxylase side activity, which explains the observed production of 7,4'-dihydroxyflavone, resokaempferol, kaempferol and apigenin, as well as the biosynthesis of the extremely rare 2-hydroxylated intermed …
It turned out that the heterologous flavanone 3-hydroxylase (F3H) has a 2-hydroxylase side activity, which explains the observed production …
Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa.
Sultana N, Lee NH. Sultana N, et al. Phytother Res. 2007 Dec;21(12):1171-6. doi: 10.1002/ptr.2230. Phytother Res. 2007. PMID: 17661332
Bioassay-guided investigation of the stems of Cornus kousa led to the isolation of 12 compounds such as four triterpenoids: betulinic acid (1), maslinic acid (2), arjunolic acid (3), 3-isoarjunolic acid (4), four flavanoids; catechin (5), epi-catechin (6), 2-hydroxynari …
Bioassay-guided investigation of the stems of Cornus kousa led to the isolation of 12 compounds such as four triterpenoids: betulinic acid ( …
Elucidation of the biosynthesis of the di-C-glycosylflavone isoschaftoside, an allelopathic component from Desmodium spp. that inhibits Striga spp. development.
Hamilton ML, Kuate SP, Brazier-Hicks M, Caulfield JC, Rose R, Edwards R, Torto B, Pickett JA, Hooper AM. Hamilton ML, et al. Phytochemistry. 2012 Dec;84:169-76. doi: 10.1016/j.phytochem.2012.08.005. Epub 2012 Sep 4. Phytochemistry. 2012. PMID: 22959223
Isoschaftoside, an allelopathic di-C-glycosylflavone from Desmodium spp. root exudates, is biosynthesised through sequential glucosylation and arabinosylation of 2-hydroxynaringenin with UDP-glucose and UDP-arabinose. Complete conversion to the flavone requires chem …
Isoschaftoside, an allelopathic di-C-glycosylflavone from Desmodium spp. root exudates, is biosynthesised through sequential glucosylation a …
23 results