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2016 1
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Page 1
Development of a 2,4-Diaminothiazole Series for the Treatment of Human African Trypanosomiasis Highlights the Importance of Static-Cidal Screening of Analogues.
Cleghorn LAT, Wall RJ, Albrecht S, MacGowan SA, Norval S, De Rycker M, Woodland A, Spinks D, Thompson S, Patterson S, Corpas Lopez V, Dey G, Collie IT, Hallyburton I, Kime R, Simeons FRC, Stojanovski L, Frearson JA, Wyatt PG, Read KD, Gilbert IH, Wyllie S. Cleghorn LAT, et al. J Med Chem. 2023 Jul 13;66(13):8896-8916. doi: 10.1021/acs.jmedchem.3c00509. Epub 2023 Jun 21. J Med Chem. 2023. PMID: 37343180 Free PMC article.
Design and Synthesis of Covalent Inhibitors of FabA.
Martin JS, Mackenzie CJ, Lin D, Homeyer N, Gray DW, Zuccotto F, Gilbert IH. Martin JS, et al. ACS Omega. 2023 Mar 27;8(14):12787-12804. doi: 10.1021/acsomega.2c08031. eCollection 2023 Apr 11. ACS Omega. 2023. PMID: 37065080 Free PMC article.
CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery.
Benns HJ, Storch M, Falco JA, Fisher FR, Tamaki F, Alves E, Wincott CJ, Milne R, Wiedemar N, Craven G, Baragaña B, Wyllie S, Baum J, Baldwin GS, Weerapana E, Tate EW, Child MA. Benns HJ, et al. Nat Microbiol. 2022 Nov;7(11):1891-1905. doi: 10.1038/s41564-022-01249-y. Epub 2022 Oct 20. Nat Microbiol. 2022. PMID: 36266336 Free PMC article.
Drug discovery research in Ghana, challenges, current efforts, and the way forward.
Amewu RK, Amoateng P, Arthur PK, Asare P, Asiamah I, Boamah D, Darko Otchere I, Dzidzor Amengor C, Ekuadzi E, Chibale K, Farrell SJ, Appiah-Oppong R, Osei-Safo D, David Read K, Hugh Gilbert I, Yeboah-Manu D. Amewu RK, et al. PLoS Negl Trop Dis. 2022 Sep 15;16(9):e0010645. doi: 10.1371/journal.pntd.0010645. eCollection 2022 Sep. PLoS Negl Trop Dis. 2022. PMID: 36107859 Free PMC article. Review.
Toolkit of Approaches To Support Target-Focused Drug Discovery for Plasmodium falciparum Lysyl tRNA Synthetase.
Milne R, Wiedemar N, Corpas-Lopez V, Moynihan E, Wall RJ, Dawson A, Robinson DA, Shepherd SM, Smith RJ, Hallyburton I, Post JM, Dowers K, Torrie LS, Gilbert IH, Baragaña B, Patterson S, Wyllie S. Milne R, et al. ACS Infect Dis. 2022 Sep 9;8(9):1962-1974. doi: 10.1021/acsinfecdis.2c00364. Epub 2022 Aug 29. ACS Infect Dis. 2022. PMID: 36037410 Free PMC article.
137 results