37000975 36748904 36746611 36125499 35967038 35934973 35901763 35504315 35194800 35041859 34861643 34793859 33988076 33609599 33577868 33313928 32786313 32668266 32616212 32333922 31694876 31419800 31369732 31202811 30825491 29328006 28474980 2710686 - Search Results

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66 results

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Clinical pharmacological innovation in the treatment of depression.

Witkin JM, Golani LK, Smith JL. Witkin JM, et al. Expert Rev Clin Pharmacol. 2023 Apr;16(4):349-362. doi: 10.1080/17512433.2023.2198703. Epub 2023 Apr 6. Expert Rev Clin Pharmacol. 2023. PMID: 37000975

Comparative anticonvulsant activity of the GABAkine KRM-II-81 and a deuterated analog.

Ping X, Meyer MJ, Zahn NM, Golani LK, Sharmin D, Pandey KP, Revanian S, Mondal P, Jin X, Arnold LA, Cerne R, Cook JM, Divović B, Savić MM, Lippa A, Smith JL, Witkin JM. Ping X, et al. Drug Dev Res. 2023 May;84(3):527-531. doi: 10.1002/ddr.22042. Epub 2023 Feb 7. Drug Dev Res. 2023. PMID: 36748904

Structural Analogs of the GABAkine KRM-II-81 Are Orally Bioavailable Anticonvulsants without Sedation.

Pandey KP, Divović B, Rashid F, Golani LK, Cerne R, Zahn NM, Meyer MJ, Arnold LA, Sharmin D, Mian MY, Smith JL, Ping X, Jin X, Lippa A, Tiruveedhula VVNPB, Cook JM, Savić MM, Witkin JM. Pandey KP, et al. J Pharmacol Exp Ther. 2023 Apr;385(1):50-61. doi: 10.1124/jpet.122.001362. Epub 2023 Feb 6. J Pharmacol Exp Ther. 2023. PMID: 36746611 Free PMC article.

Mortality of adolescents with isolated traumatic brain injury does not vary with type of level I trauma center.

Sheff ZT, Engbrecht BW, Rodgers R, Jacobson LE, Smith JL. Sheff ZT, et al. J Trauma Acute Care Surg. 2022 Oct 1;93(4):538-544. doi: 10.1097/TA.0000000000003611. Epub 2022 Apr 4. J Trauma Acute Care Surg. 2022. PMID: 36125499

Hydrochloride Salt of the GABAkine KRM-II-81.

Mian MY, Divović B, Sharmin D, Pandey KP, Golani LK, Tiruveedhula VVNPB, Cerne R, Smith JL, Ping X, Jin X, Imler GH, Deschamps JR, Lippa A, Cook JM, Savić MM, Rowlett J, Witkin JM. Mian MY, et al. ACS Omega. 2022 Jul 27;7(31):27550-27559. doi: 10.1021/acsomega.2c03029. eCollection 2022 Aug 9. ACS Omega. 2022. PMID: 35967038 Free PMC article.

Where do we go next in antidepressant drug discovery? A new generation of antidepressants: a pivotal role of AMPA receptor potentiation and mGlu2/3 receptor antagonism.

Pilc A, Machaczka A, Kawalec P, Smith JL, Witkin JM. Pilc A, et al. Expert Opin Drug Discov. 2022 Oct;17(10):1131-1146. doi: 10.1080/17460441.2022.2111415. Epub 2022 Aug 22. Expert Opin Drug Discov. 2022. PMID: 35934973

Hydrocephalus surveillance following CSF diversion: a modified Delphi study.

Hersh DS, Martin JE, Bristol RE, Browd SR, Grant G, Gupta N, Hankinson TC, Jackson EM, Kestle JRW, Krieger MD, Kulkarni AV, Madura CJ, Pindrik J, Pollack IF, Raskin JS, Riva-Cambrin J, Rozzelle CJ, Smith JL, Wellons JC. Hersh DS, et al. J Neurosurg Pediatr. 2022 Jun 17:1-11. doi: 10.3171/2022.5.PEDS22116. Online ahead of print. J Neurosurg Pediatr. 2022. PMID: 35901763

Can GABAkines quiet the noise? The GABA_A receptor neurobiology and pharmacology of tinnitus.

Witkin JM, Lippa A, Smith JL, Cook JM, Cerne R. Witkin JM, et al. Biochem Pharmacol. 2022 Jul;201:115067. doi: 10.1016/j.bcp.2022.115067. Epub 2022 Apr 30. Biochem Pharmacol. 2022. PMID: 35504315 Review.

Metabolism, pharmacokinetics, and anticonvulsant activity of a deuterated analog of the α2/3-selective GABAkine KRM-II-81.

Golani LK, Divović B, Sharmin D, Pandey KP, Mian MY, Cerne R, Zahn NM, Meyer MJ, Tiruveedhula VVNPB, Smith JL, Ping X, Jin X, Lippa A, Schkeryantz JM, Arnold LA, Cook JM, Savić MM, Witkin JM. Golani LK, et al. Biopharm Drug Dispos. 2022 Apr;43(2):66-75. doi: 10.1002/bdd.2313. Epub 2022 Mar 10. Biopharm Drug Dispos. 2022. PMID: 35194800

The imidazodiazepine, KRM-II-81: An example of a newly emerging generation of GABAkines for neurological and psychiatric disorders.

Witkin JM, Lippa A, Smith JL, Jin X, Ping X, Biggerstaff A, Kivell BM, Knutson DE, Sharmin D, Pandey KP, Mian MY, Cook JM, Cerne R. Witkin JM, et al. Pharmacol Biochem Behav. 2022 Feb;213:173321. doi: 10.1016/j.pbb.2021.173321. Epub 2022 Jan 15. Pharmacol Biochem Behav. 2022. PMID: 35041859 Review.

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