Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 8
1947 2
1948 2
1954 1
1956 1
1958 1
1961 2
1962 1
1963 3
1964 1
1965 2
1966 3
1967 2
1968 1
1969 5
1970 5
1971 4
1972 7
1973 6
1974 4
1975 10
1976 8
1977 11
1978 7
1979 8
1980 9
1981 10
1982 14
1983 17
1984 10
1985 14
1986 12
1987 6
1988 3
1989 5
1990 7
1991 10
1992 10
1993 8
1994 5
1995 11
1996 14
1997 9
1998 8
1999 12
2000 7
2001 6
2002 5
2003 13
2004 10
2005 13
2006 6
2007 8
2008 11
2009 10
2010 11
2011 10
2012 6
2013 14
2014 11
2015 10
2016 10
2017 9
2018 12
2019 11
2020 9
2021 13
2022 12
2023 9
2024 7

Text availability

Article attribute

Article type

Publication date

Search Results

519 results

Results by year

Filters applied: . Clear all
Page 1
Detection of 2-Alkyl-4-Quinolones Using Biosensors.
Fletcher MP, Diggle SP, Cámara M, Williams P. Fletcher MP, et al. Methods Mol Biol. 2018;1673:25-34. doi: 10.1007/978-1-4939-7309-5_2. Methods Mol Biol. 2018. PMID: 29130161
2-Alkyl-4-quinolones (AQs) such as 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-hydroxyquinoline (HHQ) are quorum-sensing signal molecules. Here we describe two methods for AQ detection and quantification that employ thin-layer chromatography (TLC) and microt …
2-Alkyl-4-quinolones (AQs) such as 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-hydroxyquinoline (HHQ) are quorum-sensi …
Quinolones: from antibiotics to autoinducers.
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Cámara M. Heeb S, et al. FEMS Microbiol Rev. 2011 Mar;35(2):247-74. doi: 10.1111/j.1574-6976.2010.00247.x. FEMS Microbiol Rev. 2011. PMID: 20738404 Free PMC article. Review.
However, quinolones such as the Pseudomonas quinolone signal and 2-heptyl-4-hydroxyquinoline act as quorum-sensing signal molecules, controlling the expression of many virulence genes as a function of cell population density. ...
However, quinolones such as the Pseudomonas quinolone signal and 2-heptyl-4-hydroxyquinoline act as quorum-sensing signal mole …
Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis in Pseudomonas aeruginosa colony biofilms.
Giallonardi G, Letizia M, Mellini M, Frangipani E, Halliday N, Heeb S, Cámara M, Visca P, Imperi F, Leoni L, Williams P, Rampioni G. Giallonardi G, et al. Front Cell Infect Microbiol. 2023 May 26;13:1183681. doi: 10.3389/fcimb.2023.1183681. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37305419 Free PMC article.
The pqs QS system of P. aeruginosa is responsible for the biosynthesis of diverse 2-alkyl-4-quinolones (AQs), of which 2-heptyl-4-hydroxyquinoline (HHQ) and 2-heptyl-3-hydroxy-4(1H)-quinolone (PQS) function as QS signal molecules. Transcriptomic analyses revealed th …
The pqs QS system of P. aeruginosa is responsible for the biosynthesis of diverse 2-alkyl-4-quinolones (AQs), of which 2-heptyl-4- …
Assay of MAO Inhibition by Chromatographic Techniques (HPLC/HPLC-MS).
Herraiz T. Herraiz T. Methods Mol Biol. 2023;2558:97-114. doi: 10.1007/978-1-0716-2643-6_8. Methods Mol Biol. 2023. PMID: 36169858
This work describes a chromatographic method to assay MAO A and MAO B activity by using kynuramine as a nonselective substrate and the subsequent analysis of 4-hydroxyquinoline by RP-HPLC-DAD-fluorescence and mass spectrometry (MS). ...
This work describes a chromatographic method to assay MAO A and MAO B activity by using kynuramine as a nonselective substrate and the subse …
Enzyme Inhibition Assays for Monoamine Oxidase.
Mathew B, Oh JM, Parambi DGT, Sudevan ST, Kumar S, Kim H. Mathew B, et al. Methods Mol Biol. 2024;2761:329-336. doi: 10.1007/978-1-0716-3662-6_24. Methods Mol Biol. 2024. PMID: 38427248
MAO-A and MAO-B can be assayed using kynuramine and benzylamine as substrates, respectively, at 316 nm and 250 nm, respectively, to measure their respective products, 4-hydroxyquinoline and benzaldehyde. Inhibition degree and pattern can be analyzed by using the Lin …
MAO-A and MAO-B can be assayed using kynuramine and benzylamine as substrates, respectively, at 316 nm and 250 nm, respectively, to measure …
Understanding resistance acquisition by Pseudomonas aeruginosa and possible pharmacological approaches in palliating its pathogenesis.
Thakur M, Khushboo, Kumar Y, Yadav V, Pramanik A, Dubey KK. Thakur M, et al. Biochem Pharmacol. 2023 Sep;215:115689. doi: 10.1016/j.bcp.2023.115689. Epub 2023 Jul 20. Biochem Pharmacol. 2023. PMID: 37481132 Review.
These virulence factors include pyocyanin, proteases, exotoxins, 2-heptyl-4-hydroxyquinoline N-oxide (HQNO), phospholipases, and siderophores that enable the bacteria to cause severe infections in immunocompromised individuals. ...
These virulence factors include pyocyanin, proteases, exotoxins, 2-heptyl-4-hydroxyquinoline N-oxide (HQNO), phospholipases, a …
Antioxidative or prooxidative effect of 4-hydroxyquinoline derivatives on free-radical-initiated hemolysis of erythrocytes is due to its distributive status.
Liu ZQ, Han K, Lin YJ, Luo XY. Liu ZQ, et al. Biochim Biophys Acta. 2002 Mar 15;1570(2):97-103. doi: 10.1016/s0304-4165(02)00159-9. Biochim Biophys Acta. 2002. PMID: 11985893
7-Chloro-4-hydroxyquinoline (CQ) is an antitumor drug but its efficiency is not very satisfactory. This fact motivates us to study the relationship between the structure of 4-hydroxyquinoline with various substituent and its antioxidant effect against …
7-Chloro-4-hydroxyquinoline (CQ) is an antitumor drug but its efficiency is not very satisfactory. This fact motivates us to s …
A bacterial pigment provides cross-species protection from H2O2- and neutrophil-mediated killing.
Liu Y, McQuillen EA, Rana PSJB, Gloag ES, Parsek MR, Wozniak DJ. Liu Y, et al. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2312334121. doi: 10.1073/pnas.2312334121. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170744 Free PMC article.
We found that STX production by S. aureus, either as surface-grown macrocolonies or planktonic cultures, was elevated when exposed to the P. aeruginosa exoproduct, 2-heptyl-4-hydroxyquinoline N-oxide (HQNO). This was observed with both mucoid and non-mucoid P. aerug …
We found that STX production by S. aureus, either as surface-grown macrocolonies or planktonic cultures, was elevated when exposed to the P. …
519 results