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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1955 1
1956 2
1957 2
1958 4
1959 1
1960 1
1968 1
1970 1
1975 1
1979 2
1984 2
1985 1
1987 1
1988 2
1989 2
1990 1
1991 4
1992 5
1993 3
1994 5
1995 4
1996 7
1997 1
1998 12
1999 7
2000 9
2001 11
2002 12
2003 15
2004 27
2005 16
2006 29
2007 41
2008 17
2009 35
2010 28
2011 47
2012 48
2013 60
2014 65
2015 79
2016 97
2017 95
2018 88
2019 114
2020 103
2021 88
2022 103
2023 100
2024 33

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1,260 results

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Page 1
4-Phenylbutyric acid attenuates amyloid-beta proteotoxicity through activation of HSF-1 in an Alzheimer's disease model of the nematode Caenorhabditiselegans.
Baumanns S, Muehlemeyer F, Miesbauer LC, Baake J, Roloff EM, Beis DM, Wenzel U. Baumanns S, et al. Biochem Biophys Res Commun. 2023 Sep 17;673:16-22. doi: 10.1016/j.bbrc.2023.06.064. Epub 2023 Jun 19. Biochem Biophys Res Commun. 2023. PMID: 37354655
The pathogenesis is a complex process, in which the proteotoxicity of amyloid-beta (Abeta) was identified as a major factor. 4-Phenylbutyric acid (4-PBA) is an aromatic short-chain fatty acid that may attenuate Abeta proteotoxicity through its already shown p …
The pathogenesis is a complex process, in which the proteotoxicity of amyloid-beta (Abeta) was identified as a major factor. 4-Phe …
Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes.
Xing D, Zhou Q, Wang Y, Xu J. Xing D, et al. Biol Trace Elem Res. 2023 Mar;201(3):1205-1213. doi: 10.1007/s12011-022-03193-8. Epub 2022 Mar 18. Biol Trace Elem Res. 2023. PMID: 35303254 Free PMC article.
As pharmaceutical chaperones, tauroursodeoxycholic acid (TUDCA) and 4-phenylbutyric acid (4-PBA) can effectively improve the oxidative stress of the endoplasmic reticulum. ...
As pharmaceutical chaperones, tauroursodeoxycholic acid (TUDCA) and 4-phenylbutyric acid (4-PBA) can effectively improv …
4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-alpha.
Chen SZ, Ling Y, Yu LX, Song YT, Chen XF, Cao QQ, Yu H, Chen C, Tang JJ, Fan ZC, Miao YS, Dong YP, Tao JY, Monga SPS, Wen W, Wang HY. Chen SZ, et al. Clin Transl Med. 2021 Apr;11(4):e379. doi: 10.1002/ctm2.379. Clin Transl Med. 2021. PMID: 33931972 Free PMC article.
BACKGROUND AND AIMS: 4-phenylbutyric acid (4-PBA) is a low molecular weight fatty acid that is used in clinical practice to treat inherited urea cycle disorders. ...
BACKGROUND AND AIMS: 4-phenylbutyric acid (4-PBA) is a low molecular weight fatty acid that is used in clinical practic …
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.
Kolb PS, Ayaub EA, Zhou W, Yum V, Dickhout JG, Ask K. Kolb PS, et al. Int J Biochem Cell Biol. 2015 Apr;61:45-52. doi: 10.1016/j.biocel.2015.01.015. Epub 2015 Feb 7. Int J Biochem Cell Biol. 2015. PMID: 25660369 Review.
Recently, there has been an increasing amount of literature published on the effects of 4-phenylbutyric acid (4-PBA) in various biological systems. 4-PBA is currently used clinically to treat urea cycle disorders under the trade name Buphenyl. ...
Recently, there has been an increasing amount of literature published on the effects of 4-phenylbutyric acid (4-PBA) in …
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Rzayev E, Amanvermez R, Gün S, Tiryaki ES, Arslan G. Rzayev E, et al. Neurochem Res. 2022 Oct;47(10):3104-3113. doi: 10.1007/s11064-022-03662-5. Epub 2022 Jun 28. Neurochem Res. 2022. PMID: 35764848
Endoplasmic reticulum (ER) stress and apoptosis are implicated in the pathogenesis of epilepsy. Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizure …
Endoplasmic reticulum (ER) stress and apoptosis are implicated in the pathogenesis of epilepsy. Here we examine the effects of valproic acid …
4-Phenylbutyric acid protects islet beta cell against cellular damage induced by glucocorticoids.
Zhou X, Xu Y, Gu Y, Sun M. Zhou X, et al. Mol Biol Rep. 2021 Feb;48(2):1659-1665. doi: 10.1007/s11033-021-06211-5. Epub 2021 Feb 10. Mol Biol Rep. 2021. PMID: 33566227 Free PMC article.
This study, using the MIN6 cell line, examines the effect of glucocorticoids (GCs) on the expression and protein levels of endoplasmic reticulum stress (ERS) related genes. Furthermore, we evaluated the protective role of 4-phenylbutyric acid (4-PBA) on the a …
This study, using the MIN6 cell line, examines the effect of glucocorticoids (GCs) on the expression and protein levels of endoplasmic retic …
Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice.
Zhou Q, Guo W, Jia Y, Xu J. Zhou Q, et al. Biol Trace Elem Res. 2019 Jun;189(2):501-510. doi: 10.1007/s12011-018-1494-8. Epub 2018 Aug 31. Biol Trace Elem Res. 2019. PMID: 30171596 Free PMC article.
Recent evidence has identified a role of micronutrients, such as magnesium (Mg(2+)) and calcium (Ca(2+)), in glycemic control. 4-Phenylbutyric acid (PBA) and tauroursodeoxycholic acid (TUDCA) are molecular chaperones that can improve protein folding and allev …
Recent evidence has identified a role of micronutrients, such as magnesium (Mg(2+)) and calcium (Ca(2+)), in glycemic control. 4-P …
4-phenylbutyric acid-Identity crisis; can it act as a translation inhibitor?
Stein D, Slobodnik Z, Tam B, Einav M, Akabayov B, Berstein S, Toiber D. Stein D, et al. Aging Cell. 2022 Dec;21(12):e13738. doi: 10.1111/acel.13738. Epub 2022 Nov 14. Aging Cell. 2022. PMID: 36373957 Free PMC article.
While finding molecules that can alleviate these symptoms is an important step toward solutions for these conditions, some molecules might be mischaracterized on the way. 4-phenylbutyric acid (4PBA) is known for its role as a chemical chaperone that helps all …
While finding molecules that can alleviate these symptoms is an important step toward solutions for these conditions, some molecules might b …
Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications.
He B, Moreau R. He B, et al. Pharmacol Res. 2019 Jun;144:116-131. doi: 10.1016/j.phrs.2019.04.002. Epub 2019 Apr 5. Pharmacol Res. 2019. PMID: 30954630 Review.
Concomitantly, the discovery of liporegulatory functions of certain short-chain fatty acids has generated interest in their clinical applications. In particular, butyric acid (BA) and its derivative, 4-phenylbutyric acid (PBA), which afford health benefits ag …
Concomitantly, the discovery of liporegulatory functions of certain short-chain fatty acids has generated interest in their clinical applica …
1,260 results