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Year Number of Results
1945 1
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1947 13
1948 9
1949 9
1950 8
1951 9
1952 3
1953 7
1954 5
1955 4
1956 6
1957 3
1958 8
1959 11
1960 9
1961 14
1962 18
1963 11
1964 9
1965 15
1966 25
1967 17
1968 27
1969 17
1970 21
1971 28
1972 28
1973 24
1974 26
1975 52
1976 70
1977 60
1978 55
1979 70
1980 82
1981 87
1982 117
1983 147
1984 147
1985 158
1986 169
1987 216
1988 203
1989 219
1990 248
1991 269
1992 218
1993 251
1994 240
1995 264
1996 287
1997 296
1998 310
1999 318
2000 418
2001 457
2002 439
2003 470
2004 523
2005 544
2006 616
2007 577
2008 584
2009 571
2010 596
2011 616
2012 620
2013 650
2014 654
2015 659
2016 684
2017 712
2018 733
2019 762
2020 819
2021 825
2022 861
2023 793
2024 310

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Page 1
2,4-D (Pesticides).
Food Safety Commission of Japan. Food Safety Commission of Japan. Food Saf (Tokyo). 2017 Dec 29;5(4):171-177. doi: 10.14252/foodsafetyfscj.2017010s. eCollection 2017 Dec. Food Saf (Tokyo). 2017. PMID: 32231942 Free PMC article.
Food Safety Commission of Japan (FSCJ) conducted a risk assessment of 2,4-D(1)) (CAS No. 94-75-7), a phenoxy herbicide, based on results from various studies. ...The relevant substance to the residue definition for dietary risk assessment was identified as 2,4 …
Food Safety Commission of Japan (FSCJ) conducted a risk assessment of 2,4-D(1)) (CAS No. 94-75-7), a phenoxy herbicide, based …
Pyrazolo[3,4-d]pyrimidine scaffold: A review on synthetic approaches and EGFR and VEGFR inhibitory activities.
Kassab AE. Kassab AE. Arch Pharm (Weinheim). 2023 Jan;356(1):e2200424. doi: 10.1002/ardp.202200424. Epub 2022 Oct 3. Arch Pharm (Weinheim). 2023. PMID: 36192144 Review.
The pyrazolo[3,4-d]pyrimidine core has received a lot of interest from the medicinal chemistry community as a promising framework for drug design and discovery. ...Many successful anticancer medicines have been designed and synthesized using pyrazolo[3,4-d …
The pyrazolo[3,4-d]pyrimidine core has received a lot of interest from the medicinal chemistry community as a promising framew …
Animal models in the neurotoxicology of 2,4-D.
Freitas LM, Valadares LA, Camozzi M, de Oliveira PG, Ferreira Machado MR, Lima FC. Freitas LM, et al. Hum Exp Toxicol. 2019 Oct;38(10):1178-1182. doi: 10.1177/0960327119860172. Epub 2019 Jun 30. Hum Exp Toxicol. 2019. PMID: 31256685 Review.
2,4-D is a selective pre- and postemergence herbicide used for several crops. ...The worst neuropathologic effects were observed in fish. Since most studies focused on the neurotoxicity of 2,4-D in rodents, the effect it may have on other species and g …
2,4-D is a selective pre- and postemergence herbicide used for several crops. ...The worst neuropathologic effects were observ …
Inheritance of 2,4-dichlorophenoxyacetic acid (2,4-D) resistance in Amaranthus palmeri.
Shyam C, Peterson DE, Jhala AJ, Jugulam M. Shyam C, et al. Sci Rep. 2022 Dec 17;12(1):21822. doi: 10.1038/s41598-022-25686-1. Sci Rep. 2022. PMID: 36528649 Free PMC article.
In this study, the inheritance of 2,4-D resistance in a multiple herbicide-resistant Palmer amaranth (KCTR) was investigated. ...In future, efforts will be directed towards identifying genes mediating 2,4-D resistance in KCTR population....
In this study, the inheritance of 2,4-D resistance in a multiple herbicide-resistant Palmer amaranth (KCTR) was investigated. …
2,4-Dichlorophenoxyacetic acid (2,4-D) affects DNA integrity and retina structure in zebrafish larvae.
Gaaied S, Oliveira M, Barreto A, Zakhama A, Banni M. Gaaied S, et al. Environ Sci Pollut Res Int. 2022 Dec;29(56):85402-85412. doi: 10.1007/s11356-022-21793-8. Epub 2022 Jul 6. Environ Sci Pollut Res Int. 2022. PMID: 35794326
Retinal development toxicity was evaluated with histological approach. The results obtained revealed that 2,4-D alters DNA integrity of zebrafish larvae. Moreover, transcriptomic data showed a significant induction of p-53 and casp-3 genes and a significant decrease …
Retinal development toxicity was evaluated with histological approach. The results obtained revealed that 2,4-D alters DNA int …
2,4-D and 2,4-D butoxyethyl ester behavior in Eurasian and hybrid watermilfoil (Myriophyllum spp.).
Ortiz MF, Figueiredo MR, Nissen SJ, Wersal RM, Ratajczyk WA, Dayan FE. Ortiz MF, et al. Pest Manag Sci. 2022 Feb;78(2):626-632. doi: 10.1002/ps.6671. Epub 2021 Oct 23. Pest Manag Sci. 2022. PMID: 34626161
These Eurasian and northern watermilfoil hybrids (HWM) grow 30% faster and in many cases are less sensitive to 2,4-dichlorophenoxy acetic acid (2,4-D) than either parent. The mechanism(s) impacting 2,4-D tolerance in these hybrids was investigated by c …
These Eurasian and northern watermilfoil hybrids (HWM) grow 30% faster and in many cases are less sensitive to 2,4-dichlorophenoxy acetic ac …
Recent green approaches for the synthesis of pyrazolo[3,4-d]pyrimidines: A mini review.
Maher M, Zaher AF, Mahmoud Z, Kassab AE. Maher M, et al. Arch Pharm (Weinheim). 2022 Jun;355(6):e2100470. doi: 10.1002/ardp.202100470. Epub 2022 Mar 4. Arch Pharm (Weinheim). 2022. PMID: 35244962 Review.
Pyrazolo[3,4-d]pyrimidine as a bioisostere of purine has drawn considerable attention as a privileged scaffold for the design and discovery of novel drugs. ...The present mini review reflects recent advances in the green synthesis of pyrazolo[3,4-d]pyr …
Pyrazolo[3,4-d]pyrimidine as a bioisostere of purine has drawn considerable attention as a privileged scaffold for the design …
The association between 2,4-D and serum testosterone levels: NHANES 2013-2014.
Glover FE, Del Giudice F, Belladelli F, Ryan PB, Chen T, Eisenberg ML, Caudle WM. Glover FE, et al. J Endocrinol Invest. 2022 Apr;45(4):787-796. doi: 10.1007/s40618-021-01709-y. Epub 2021 Nov 27. J Endocrinol Invest. 2022. PMID: 34837643
METHODS: Using data from a cross-sectional study of 456 adult men in the 2013-2014 NHANES survey cycle, we examined the relationship between urinary concentrations of 2,4-D and serum testosterone levels. RESULTS: Multivariable regression models adjusting for potenti …
METHODS: Using data from a cross-sectional study of 456 adult men in the 2013-2014 NHANES survey cycle, we examined the relationship between …
2,4-dichlorophenoxyacetic acid (2,4-D) exposure during postnatal development alters the effects of western diet on mouse prostate.
Rocha VA, Aquino AM, Magosso N, Souza PV, Justulin LA, Domeniconi RF, Barbisan LF, Romualdo GR, Scarano WR. Rocha VA, et al. Reprod Toxicol. 2023 Sep;120:108449. doi: 10.1016/j.reprotox.2023.108449. Epub 2023 Jul 28. Reprod Toxicol. 2023. PMID: 37516258
Male C57Bl/6J mice received simultaneously a WD and 2,4-D at doses of 0.02, 2.0, or 20.0 mg/kg b.w./day for 6 months. ...Our results showed that 2,4-D was able to modulate the effects caused by WD, mainly at lower doses. ...
Male C57Bl/6J mice received simultaneously a WD and 2,4-D at doses of 0.02, 2.0, or 20.0 mg/kg b.w./day for 6 months. ...Our r …
Review of 2,4-dichlorophenoxyacetic acid (2,4-D) epidemiology and toxicology.
Garabrant DH, Philbert MA. Garabrant DH, et al. Crit Rev Toxicol. 2002 Jul;32(4):233-57. doi: 10.1080/20024091064237. Crit Rev Toxicol. 2002. PMID: 12184504 Review.
Overall, the available evidence from epidemiologic studies is not adequate to conclude that any form of cancer is causally associated with 2,4-D exposure. There is no human evidence of adverse reproductive outcomes related to 2,4-D. ...At high doses, 2 …
Overall, the available evidence from epidemiologic studies is not adequate to conclude that any form of cancer is causally associated with 2 …
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