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Metabolic activation of 4H-cyclopenta[def]chrysene in human mammary carcinoma MCF-7 cell cultures.
Agarwal R, Coffing SL, Baird WM, Harvey RG, Dipple A. Agarwal R, et al. Chem Res Toxicol. 1999 May;12(5):437-41. doi: 10.1021/tx980258r. Chem Res Toxicol. 1999. PMID: 10328754
The tumor initiating activities of 4H-cyclopenta[def]chrysene (C[def]C) and its two putative reactive metabolites, trans-1, 2-dihydroxy-anti-3,3a-epoxy-1,2,3, 3a-tetrahydro-4H-cyclopenta[def]chrysene (C[def]C-3,3a-DE) and trans-6,7-dihydroxy-anti-8,9-e …
The tumor initiating activities of 4H-cyclopenta[def]chrysene (C[def]C) and its two putative reactive metabolites, trans-1, 2- …
Tumorigenicity in newborn mice of fjord region and other sterically hindered diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene.
Amin S, Desai D, Dai W, Harvey RG, Hecht SS. Amin S, et al. Carcinogenesis. 1995 Nov;16(11):2813-7. doi: 10.1093/carcin/16.11.2813. Carcinogenesis. 1995. PMID: 7586203
Diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene were tested for tumorigenicity in newborn mice. The compounds tested were racemic trans-11,12-dihydroxy-anti-13,14-epoxy-11,12,13, 14-tetrahyd …
Diol epoxides of benzo[g]chrysene, dibenzo[a,l]pyrene (dibenzo[def,p]chrysene), 4H-cyclopenta[def]chrysene and fluoranthene we …
Methylene-bridged bay region chrysene and phenanthrene derivatives and their keto-analogs: mutagenicity in Salmonella typhimurium and tumor-initiating activity on mouse skin.
Rice JE, Makowski GS, Hosted TJ Jr, Lavoie EJ. Rice JE, et al. Cancer Lett. 1985 Jun;27(2):199-206. doi: 10.1016/0304-3835(85)90108-9. Cancer Lett. 1985. PMID: 3891075
A series of methylene-bridged and keto-bridged bay region derivatives of chrysene and phenanthrene were prepared and evaluated for mutagenic activity in Salmonella typhimurium TA100 and for tumor-initiating activity on CD-1 mouse skin. The compounds included in this series were …
A series of methylene-bridged and keto-bridged bay region derivatives of chrysene and phenanthrene were prepared and evaluated for mutagenic …