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Why Build Whole-Cell Models?
Carrera J, Covert MW. Carrera J, et al. Trends Cell Biol. 2015 Dec;25(12):719-722. doi: 10.1016/j.tcb.2015.09.004. Epub 2015 Oct 21. Trends Cell Biol. 2015. PMID: 26471224 Free PMC article.
Accelerated discovery via a whole-cell model.
Sanghvi JC, Regot S, Carrasco S, Karr JR, Gutschow MV, Bolival B Jr, Covert MW. Sanghvi JC, et al. Nat Methods. 2013 Dec;10(12):1192-5. doi: 10.1038/nmeth.2724. Epub 2013 Nov 3. Nat Methods. 2013. PMID: 24185838 Free PMC article.
Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models.
Karr JR, Williams AH, Zucker JD, Raue A, Steiert B, Timmer J, Kreutz C; DREAM8 Parameter Estimation Challenge Consortium; Wilkinson S, Allgood BA, Bot BM, Hoff BR, Kellen MR, Covert MW, Stolovitzky GA, Meyer P. Karr JR, et al. PLoS Comput Biol. 2015 May 28;11(5):e1004096. doi: 10.1371/journal.pcbi.1004096. eCollection 2015 May. PLoS Comput Biol. 2015. PMID: 26020786 Free PMC article.