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6-Paradol Acts as a Potential Anti-obesity Vanilloid from Grains of Paradise.
Hattori H, Mori T, Shibata T, Kita M, Mitsunaga T. Hattori H, et al. Mol Nutr Food Res. 2021 Aug;65(16):e2100185. doi: 10.1002/mnfr.202100185. Epub 2021 Jun 30. Mol Nutr Food Res. 2021. PMID: 33793045
Additionally, 6-paradol suppresses the hepatic cholesterol and triglyceride and significantly decreases the gene expression related to fatty acid synthesis, lipid transportation, and adipocyte differentiation in both liver and adipose tissue. Moreover, phosphorylati …
Additionally, 6-paradol suppresses the hepatic cholesterol and triglyceride and significantly decreases the gene expression re …
6-Paradol Alleviates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Inhibiting AKT/mTOR Axis.
Binmahfouz LS, Almukadi H, Alamoudi AJ, El-Halawany AM, Abdallah HM, Algandaby MM, Mohamed GA, Ibrahim SRM, Alghamdi FA, Al-Shaeri M, Abdel-Naim AB. Binmahfouz LS, et al. Plants (Basel). 2022 Oct 3;11(19):2602. doi: 10.3390/plants11192602. Plants (Basel). 2022. PMID: 36235468 Free PMC article.
INTRODUCTION: Benign prostatic hyperplasia (BPH) is a common disease among elderly men. Its pharmacological treatment is still unsatisfactory. 6-Paradol (6-PD) is an active metabolite found in many members of the Zingiberaceae family. ...
INTRODUCTION: Benign prostatic hyperplasia (BPH) is a common disease among elderly men. Its pharmacological treatment is still unsatisfactor …
[6]-Paradol suppresses proliferation and metastases of pancreatic cancer by decreasing EGFR and inactivating PI3K/AKT signaling.
Jiang X, Wang J, Chen P, He Z, Xu J, Chen Y, Liu X, Jiang J. Jiang X, et al. Cancer Cell Int. 2021 Aug 10;21(1):420. doi: 10.1186/s12935-021-02118-0. Cancer Cell Int. 2021. PMID: 34376189 Free PMC article.
METHODS: Functional assays were performed to investigate the role of [6]-Paradol (6-P) in proliferation and metastasis of pancreatic cancer in vitro and in vivo. ...
METHODS: Functional assays were performed to investigate the role of [6]-Paradol (6-P) in proliferation and metastasis of panc …
Protective effect of 6-paradol in acetic acid-induced ulcerative colitis in rats.
Rafeeq M, Murad HAS, Abdallah HM, El-Halawany AM. Rafeeq M, et al. BMC Complement Med Ther. 2021 Jan 13;21(1):28. doi: 10.1186/s12906-021-03203-7. BMC Complement Med Ther. 2021. PMID: 33441125 Free PMC article.
Current study evaluates the effect of 6-paradol in amelioration of ulcerative colitis in rats for the first time. METHODS: 6-Paradol (95% purity) was obtained from seeds of Aframomum melegueta. ...
Current study evaluates the effect of 6-paradol in amelioration of ulcerative colitis in rats for the first time. METHODS: …
6-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways.
El-Maadawy WH, Hassan M, Abdou RM, El-Dine RS, Aboushousha T, El-Tanbouly ND, El-Sayed AM. El-Maadawy WH, et al. Environ Toxicol Pharmacol. 2022 Apr;91:103817. doi: 10.1016/j.etap.2022.103817. Epub 2022 Jan 25. Environ Toxicol Pharmacol. 2022. PMID: 35091105
With the absence of satisfactory treatment, we investigated the protective effects of 6-Paradol (PDL) against DIC-induced AKI, with focus on renal autophagy and NLRP3 inflammasome pathways . ...
With the absence of satisfactory treatment, we investigated the protective effects of 6-Paradol (PDL) against DIC-induced AKI, …
6-Paradol and its glucoside improve memory disorder in mice.
Yamaguchi K , Mitsunaga T , Yamauchi K . Yamaguchi K , et al. Food Funct. 2020 Nov 18;11(11):9892-9902. doi: 10.1039/d0fo01975e. Food Funct. 2020. PMID: 33094793
In this study, the effects of 6-paradol (6P) and 6-paradol-beta-glucoside (6PG) on neuritogenesis were investigated using PC12 cells. ...
In this study, the effects of 6-paradol (6P) and 6-paradol-beta-glucoside (6PG) on neuritogenesis were investiga …
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
Kim HJ, Kim IS, Rehman SU, Ha SK, Nakamura K, Yoo HH. Kim HJ, et al. Bioorg Med Chem Lett. 2017 Apr 15;27(8):1826-1830. doi: 10.1016/j.bmcl.2017.02.047. Epub 2017 Feb 20. Bioorg Med Chem Lett. 2017. PMID: 28274629
In this study, the inhibitory effects of 6-paradol on the activities of cytochrome P450 (CYP) enzymes were investigated with human liver microsomes and recombinant CYP isozymes. 6-Paradol showed concentration-dependent inhibitory effects on CYP1A2, CYP …
In this study, the inhibitory effects of 6-paradol on the activities of cytochrome P450 (CYP) enzymes were investigated with h …
Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis.
Sapkota A, Park SJ, Choi JW. Sapkota A, et al. Biomol Ther (Seoul). 2019 Mar 1;27(2):152-159. doi: 10.4062/biomolther.2018.089. Biomol Ther (Seoul). 2019. PMID: 30001610 Free PMC article.
Previous studies have reported that 6-shogaol, a major constituent of ginger (Zingiber officinale rhizome), and its biological metabolite, 6-paradol, have anti-inflammatory and anti-oxidative properties in the central nervous system (CNS). ...Administration of 6-sho …
Previous studies have reported that 6-shogaol, a major constituent of ginger (Zingiber officinale rhizome), and its biological metabolite, …
Nutritional implications of ginger: chemistry, biological activities and signaling pathways.
Kiyama R. Kiyama R. J Nutr Biochem. 2020 Dec;86:108486. doi: 10.1016/j.jnutbio.2020.108486. Epub 2020 Aug 19. J Nutr Biochem. 2020. PMID: 32827666 Review.
To understand the beneficial characteristics of ginger, especially its physiological and pharmacological activities at the molecular level, the biological effects of ginger constituents, such as monoterpenes (cineole, citral, limonene and alpha/beta-pinenes), sesquiterpenes (beta …
To understand the beneficial characteristics of ginger, especially its physiological and pharmacological activities at the molecular level, …
6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice.
Wei CK, Tsai YH, Korinek M, Hung PH, El-Shazly M, Cheng YB, Wu YC, Hsieh TJ, Chang FR. Wei CK, et al. Int J Mol Sci. 2017 Jan 17;18(1):168. doi: 10.3390/ijms18010168. Int J Mol Sci. 2017. PMID: 28106738 Free PMC article.
Therefore, we prepared 10 ginger active components, namely 6-, 8-, 10-paradols, 6-, 8-, 10-shogaols, 6-, 8-, 10-gingerols and zingerone, and evaluated their anti-hyperglycemic activity. Among the tested compounds, 6-paradol and 6-shogaol showed potent activity in st …
Therefore, we prepared 10 ginger active components, namely 6-, 8-, 10-paradols, 6-, 8-, 10-shogaols, 6-, 8-, 10-gingerols and zingerone, and …
74 results