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A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV, Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X, Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD, Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A, Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA, Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL, Nayak U, N'diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL, Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S, Speliotes… See abstract for full author list ➔ Monda KL, et al. Nat Genet. 2013 Jun;45(6):690-6. doi: 10.1038/ng.2608. Epub 2013 Apr 14. Nat Genet. 2013. PMID: 23583978 Free PMC article.
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the associatio …
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index …
Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI.
Gong J, Nishimura KK, Fernandez-Rhodes L, Haessler J, Bien S, Graff M, Lim U, Lu Y, Gross M, Fornage M, Yoneyama S, Isasi CR, Buzkova P, Daviglus M, Lin DY, Tao R, Goodloe R, Bush WS, Farber-Eger E, Boston J, Dilks HH, Ehret G, Gu CC, Lewis CE, Nguyen KH, Cooper R, Leppert M, Irvin MR, Bottinger EP, Wilkens LR, Haiman CA, Park L, Monroe KR, Cheng I, Stram DO, Carlson CS, Jackson R, Kuller L, Houston D, Kooperberg C, Buyske S, Hindorff LA, Crawford DC, Loos RJF, Le Marchand L, Matise TC, North KE, Peters U. Gong J, et al. Int J Obes (Lond). 2018 Mar;42(3):384-390. doi: 10.1038/ijo.2017.304. Epub 2017 Dec 21. Int J Obes (Lond). 2018. PMID: 29381148 Free PMC article.
OBJECTIVE: Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases and negative health outcomes. ...We aim to replicate known BMI loci and identify novel associations in a trans-ethnic s …
OBJECTIVE: Body mass index (BMI) is commonly used to assess obesity, which is associated with numerous diseases …
Three pleiotropic loci associated with bone mineral density and lean body mass.
Zhang YX, Zhang SS, Ran S, Liu Y, Zhang H, Yang XL, Hai R, Shen H, Tian Q, Deng HW, Zhang L, Pei YF. Zhang YX, et al. Mol Genet Genomics. 2021 Jan;296(1):55-65. doi: 10.1007/s00438-020-01724-3. Epub 2020 Sep 24. Mol Genet Genomics. 2021. PMID: 32970232 Free PMC article.
Both bone mineral density (BMD) and lean body mass (LBM) are important physiological measures with strong genetic determination. ...Combining the results from discovery meta-analysis and replication sample, we identified three genomic loci …
Both bone mineral density (BMD) and lean body mass (LBM) are important physiological measures with strong genetic determinatio …
Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.
Hong J, Hatchell KE, Bradfield JP, Bjonnes A, Chesi A, Lai CQ, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP, Bowden DW, Gilsanz V, Houston DK, Kalkwarf HJ, Kelly A, Lappe JM, Liu Y, Michos ED, Oberfield SE, Palmer ND, Rotter JI, Sapkota B, Shepherd JA, Wilson JG, Basu S, de Boer IH, Divers J, Freedman BI, Grant SFA, Hakanarson H, Harris TB, Kestenbaum BR, Kritchevsky SB, Loos RJF, Norris JM, Norwood AF, Ordovas JM, Pankow JS, Psaty BM, Sanghera DK, Wagenknecht LE, Zemel BS, Meigs J, Dupuis J, Florez JC, Wang T, Liu CT, Engelman CD, Billings LK. Hong J, et al. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1380-1392. doi: 10.1210/jc.2017-01802. J Clin Endocrinol Metab. 2018. PMID: 29325163 Free PMC article.
Although the genetic determinants underlying vitamin D inadequacy have been studied in people of European ancestry, less is known about populations with Hispanic or African ancestry. ...DESIGN: Ancestry-specific (Hispanic and African) and …
Although the genetic determinants underlying vitamin D inadequacy have been studied in people of European ancestry, less is kn …
Genome-wide association study of body mass index in subjects with alcohol dependence.
Polimanti R, Zhang H, Smith AH, Zhao H, Farrer LA, Kranzler HR, Gelernter J. Polimanti R, et al. Addict Biol. 2017 Mar;22(2):535-549. doi: 10.1111/adb.12317. Epub 2015 Oct 12. Addict Biol. 2017. PMID: 26458734 Free PMC article.
Outcomes related to disordered metabolism are common in alcohol dependence (AD). To investigate alterations in the regulation of body mass that occur in the context of AD, we performed a genome-wide association study (GWAS) of body mass index …
Outcomes related to disordered metabolism are common in alcohol dependence (AD). To investigate alterations in the regulation of body …
Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.
Justice AE, Young K, Gogarten SM, Sofer T, Graff M, Love SAM, Wang Y, Klimentidis YC, Cruz M, Guo X, Hartwig F, Petty L, Yao J, Allison MA, Below JE, Buchanan TA, Chen YI, Goodarzi MO, Hanis C, Highland HM, Hsueh WA, Ipp E, Parra E, Palmas W, Raffel LJ, Rotter JI, Tan J, Taylor KD, Valladares A, Xiang AH, Sánchez-Johnsen L, Isasi CR, North KE. Justice AE, et al. Hum Mol Genet. 2021 Nov 1;30(22):2190-2204. doi: 10.1093/hmg/ddab166. Hum Mol Genet. 2021. PMID: 34165540 Free PMC article.
Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central adiposity measured as waist-to-hip ratio (WHR), waist circumference (WC) and hip circumference (HIP) adjusted f …
Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci …
A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women.
Taylor KC, Evans DS, Edwards DRV, Edwards TL, Sofer T, Li G, Liu Y, Franceschini N, Jackson RD, Giri A, Donneyong M, Psaty B, Rotter JI, LaCroix AZ, Jordan JM, Robbins JA, Lewis B, Stefanick ML, Liu Y, Garcia M, Harris T, Cauley JA, North KE. Taylor KC, et al. Bone Rep. 2016 Aug 27;5:233-242. doi: 10.1016/j.bonr.2016.08.005. eCollection 2016 Dec. Bone Rep. 2016. PMID: 28580392 Free PMC article.
The purpose of this hypothesis-generating study was to identify possible genetic determinants of fracture among African American (AA) women in a GWAS meta-analysis. ...Possible reasons for the lack of generalization are discussed. CONCLUSION: This GWAS …
The purpose of this hypothesis-generating study was to identify possible genetic determinants of fracture among African Americ …
Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure.
Huang Y, Ollikainen M, Muniandy M, Zhang T, van Dongen J, Hao G, van der Most PJ, Pan Y, Pervjakova N, Sun YV, Hui Q, Lahti J, Fraszczyk E, Lu X, Sun D, Richard MA, Willemsen G, Heikkila K, Mateo Leach I, Mononen N, Kähönen M, Hurme MA, Raitakari OT, Drake AJ, Perola M, Nuotio ML, Huang Y, Khulan B, Räikkönen K, Wolffenbuttel BHR, Zhernakova A, Fu J, Zhu H, Dong Y, van Vliet-Ostaptchouk JV, Franke L, Eriksson JG, Fornage M, Milani L, Lehtimäki T, Vaccarino V, Boomsma DI, van der Harst P, de Geus EJC, Salomaa V, Li S, Chen W, Su S, Wilson J, Snieder H, Kaprio J, Wang X. Huang Y, et al. Hypertension. 2020 Jul;76(1):195-205. doi: 10.1161/HYPERTENSIONAHA.120.14973. Epub 2020 Jun 10. Hypertension. 2020. PMID: 32520614 Free PMC article.
We conducted an epigenome-wide association study meta-analysis on blood pressure (BP) in 4820 individuals of European and African ancestry aged 14 to 69. Genome-wide DNA methylation data from peripheral leukocytes were obtained using the …
We conducted an epigenome-wide association study meta-analysis on blood pressure (BP) in 4820 individuals of Eur …
Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.
Sung YJ, Pérusse L, Sarzynski MA, Fornage M, Sidney S, Sternfeld B, Rice T, Terry JG, Jacobs DR Jr, Katzmarzyk P, Curran JE, Jeffrey Carr J, Blangero J, Ghosh S, Després JP, Rankinen T, Rao DC, Bouchard C. Sung YJ, et al. Int J Obes (Lond). 2016 Apr;40(4):662-74. doi: 10.1038/ijo.2015.217. Epub 2015 Oct 20. Int J Obes (Lond). 2016. PMID: 26480920 Free PMC article.
BACKGROUND: To identify loci associated with abdominal fat and replicate prior findings, we performed genome-wide association (GWA) studies of abdominal fat traits: subcutaneous adipose tissue (SAT); visceral adipose tissue (VAT); total adipose tissue …
BACKGROUND: To identify loci associated with abdominal fat and replicate prior findings, we performed genome-wide as …
Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium.
Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen WM, Chesi A, Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Allison MA, Ambrosone CB, Bandera EV, Bartz TM, Berndt SI, Bernstein L, Blot WJ, Bottinger EP, Carpten J, Chanock SJ, Chen YI, Conti DV, Cooper RS, Fornage M, Freedman BI, Garcia M, Goodman PJ, Hsu YH, Hu J, Huff CD, Ingles SA, John EM, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi A, Olshan A, Press MF, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick DS, Stanford JL, Stevens VL, Stram A, Strom SS, Vaidya D, Witte JS, Yao J, Zhu X, Ziegler RG, Zonderman AB, Adeyemo A, Ambs S, Cushman M, Faul JD, Hakonarson H, Levin AM, Nathanson KL, Ware EB, Weir DR, Zhao W, Zhi D; Bone Mineral Density in Childhood Study (BMDCS) Group; Arnett DK, Grant SFA, Kardia SLR, Oloapde OI, Rao DC, Rotimi CN, Sale MM, Williams LK, Zemel BS, Becker DM, Borecki IB, Evans MK, Harris TB, Hirschhorn JN, Li Y, Patel SR, Psaty BM, Rotter JI, Wilson JG, Bowden DW, Cupples LA, Haiman… See abstract for full author list ➔ Ng MCY, et al. PLoS Genet. 2017 Apr 21;13(4):e1006719. doi: 10.1371/journal.pgen.1006719. eCollection 2017 Apr. PLoS Genet. 2017. PMID: 28430825 Free PMC article.
Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity including body mass index (BMI) and waist-to-hip ratio (adjusted for BMI, WHRadjBMI), but few have been identified thr …
Genome-wide association studies (GWAS) have identified >300 loci associated with measures of adiposity includ …