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Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
Blanc V, Riordan JD, Soleymanjahi S, Nadeau JH, Nalbantoglu I, Xie Y, Molitor EA, Madison BB, Brunt EM, Mills JC, Rubin DC, Ng IO, Ha Y, Roberts LR, Davidson NO. Blanc V, et al. J Clin Invest. 2021 Jan 4;131(1):e138699. doi: 10.1172/JCI138699. J Clin Invest. 2021. PMID: 33445170 Free PMC article.
The RNA-binding protein Apobec1 complementation factor (A1CF) regulates posttranscriptional ApoB mRNA editing, but the range of RNA targets and the long-term effect of altered A1CF expression on liver function are unknown. Here we studied hepatocyte-specific A1cf …
The RNA-binding protein Apobec1 complementation factor (A1CF) regulates posttranscriptional ApoB mRNA editing, but the range of RNA t …
High APOBEC1 Complementation Factor Expression Positively Modulates the Proliferation, Invasion, and Migration of Endometrial Cancer Cells Through Regulating P53/P21 Signaling Pathway.
Liu Q, Chen CY, Chen GL. Liu Q, et al. Cancer Biother Radiopharm. 2022 Nov;37(9):750-758. doi: 10.1089/cbr.2020.3957. Epub 2020 Aug 18. Cancer Biother Radiopharm. 2022. PMID: 32818382
Background: APOBEC1 complementation factor (A1CF) is a component of the apolipoprotein-B messenger RNA editing complex that participates in various cellular processes and acts as an oncogene in many cancers. In this study, it was aimed to investigate the roles of …
Background: APOBEC1 complementation factor (A1CF) is a component of the apolipoprotein-B messenger RNA editing complex that participa …
A1CF-promoted colony formation and proliferation of RCC depends on DKK1-MEK/ERK signal axis.
Ni D, Yi Q, Liu J, Hu Y, Lv T, Tan G, Liu Y, Xu L, Xia H, Zhou Q, Xie Y. Ni D, et al. Gene. 2020 Mar 10;730:144299. doi: 10.1016/j.gene.2019.144299. Epub 2019 Dec 24. Gene. 2020. PMID: 31881249
Decreased A1CF expression inhibits the proliferation and colony formation of 786-O cells; and further signaling pathway screening demonstrated that A1CF increases ERK activation and DKK1 expression. ...Decreasing of DKK1 expression reduces the phosphorylation of ERK …
Decreased A1CF expression inhibits the proliferation and colony formation of 786-O cells; and further signaling pathway screening dem …
A1CF-Axin2 signal axis regulates apoptosis and migration in Wilms tumor-derived cells through Wnt/beta-catenin pathway.
Ni D, Liu J, Hu Y, Liu Y, Gu Y, Zhou Q, Xie Y. Ni D, et al. In Vitro Cell Dev Biol Anim. 2019 Apr;55(4):252-259. doi: 10.1007/s11626-019-00335-6. Epub 2019 Mar 1. In Vitro Cell Dev Biol Anim. 2019. PMID: 30825095
Here, we explored the regulatory function of A1CF in Wilms tumor-derived cells. Quantitative real-time PCR was performed to detect the mRNA level of A1CF, Axin2, beta-Catenin, CCND1 or NKD1 in A1CF-depleted or A1CF-overexpression G401 cells. ...Our stu …
Here, we explored the regulatory function of A1CF in Wilms tumor-derived cells. Quantitative real-time PCR was performed to detect th …
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg RP, Brown MJ, Gaffo AL, Pirastu N, Li G, Hayward C, Zemunik T, Huffman J, Yengo L, Zhao JH, Demirkan A, Feitosa MF, Liu X, Malerba G, Lopez LM, van der Harst P, Li X, Kleber ME, Hicks AA, Nolte IM, Johansson A, Murgia F, Wild SH, Bakker SJ, Peden JF, Dehghan A, Steri M, Tenesa A, Lagou V, Salo P, Mangino M, Rose LM, Lehtimäki T, Woodward OM, Okada Y, Tin A, Müller C, Oldmeadow C, Putku M, Czamara D, Kraft P, Frogheri L, Thun GA, Grotevendt A, Gislason GK, Harris TB, Launer LJ, McArdle P, Shuldiner AR, Boerwinkle E, Coresh J, Schmidt H, Schallert M, Martin NG, Montgomery GW, Kubo M, Nakamura Y, Tanaka T, Munroe PB, Samani NJ, Jacobs DR Jr, Liu K, D'Adamo P, Ulivi S, Rotter JI, Psaty BM, Vollenweider P, Waeber G, Campbell S, Devuyst O, Navarro P, Kolcic I, Hastie N, Balkau B, Froguel P, Esko T, Salumets A, Khaw KT, Langenberg C, Wareham NJ, Isaacs A, Kraja A, Zhang Q, Wild PS, Scott RJ, Holliday EG, Org E, Viigimaa M, Bandinelli S, Metter JE, Lupo A, Trabetti E, Sorice R, Döring A, Latt… See abstract for full author list ➔ Köttgen A, et al. Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500. Epub 2012 Dec 23. Nat Genet. 2013. PMID: 23263486 Free PMC article.
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TM …
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and re …
Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells.
Song Y, Shao L, Xue Y, Ruan X, Liu X, Yang C, Zheng J, Shen S, Chen J, Li Z, Liu Y. Song Y, et al. J Exp Clin Cancer Res. 2019 Jun 11;38(1):248. doi: 10.1186/s13046-019-1200-5. J Exp Clin Cancer Res. 2019. PMID: 31186064 Free PMC article.
Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular processes by modulating RNA expression, and acts as an oncogene in breast cancer. ...RESULTS: A1CF was upregulated and functio …
Accumulating evidence has highlighted that RNA binding protein APOBEC1 complementation factor (A1CF) is involved in various cellular …
APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells.
Xia H, Liu Y, Xu L, Mao H, Zhou Q, Xie Y. Xia H, et al. In Vitro Cell Dev Biol Anim. 2021 May;57(5):501-509. doi: 10.1007/s11626-021-00589-z. Epub 2021 May 17. In Vitro Cell Dev Biol Anim. 2021. PMID: 34002283
Wound healing assay was conducted to detect migration in A1CF overexpression and knockdown stable cell lines. Quantitative PCR and western blot assays were utilized to test transcriptional and translation levels of A1CF and SMAD3 in A1CF overexpression and kn …
Wound healing assay was conducted to detect migration in A1CF overexpression and knockdown stable cell lines. Quantitative PCR and we …
A1CF Binding to the p65 Interaction Site on NKRF Decreased IFN-beta Expression and p65 Phosphorylation (Ser536) in Renal Carcinoma Cells.
Liu Y, Yang J, Weng D, Xie Y. Liu Y, et al. Int J Mol Sci. 2024 Mar 22;25(7):3576. doi: 10.3390/ijms25073576. Int J Mol Sci. 2024. PMID: 38612387 Free PMC article.
Truncation of A1CF or deletion on NKRF revealed that the RRM1 domain of A1CF and the p65 binding motif of NKRF are required for their interaction. Deletion of RRM1 on A1CF abrogates NKRF binding, and the decrease in IFN-beta expression and p65(Ser536) phospho …
Truncation of A1CF or deletion on NKRF revealed that the RRM1 domain of A1CF and the p65 binding motif of NKRF are required fo …
Parent-of-origin effects of A1CF and AGO2 on testicular germ-cell tumors, testicular abnormalities, and fertilization bias.
Carouge D, Blanc V, Knoblaugh SE, Hunter RJ, Davidson NO, Nadeau JH. Carouge D, et al. Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5425-33. doi: 10.1073/pnas.1604773113. Epub 2016 Aug 31. Proc Natl Acad Sci U S A. 2016. PMID: 27582469 Free PMC article.
Testicular tumors, the most common cancer in young men, arise from abnormalities in germ cells during fetal development. ...In addition, non-Mendelian inheritance was found among progeny of A1cf and Ago2 mutant intercrosses but not in backcrosses and without fetal l …
Testicular tumors, the most common cancer in young men, arise from abnormalities in germ cells during fetal development. ...In additi …
Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells.
Wolfe AD, Arnold DB, Chen XS. Wolfe AD, et al. J Mol Biol. 2019 Mar 29;431(7):1506-1517. doi: 10.1016/j.jmb.2019.02.025. Epub 2019 Mar 4. J Mol Biol. 2019. PMID: 30844405 Free PMC article.
APOBEC1 cytosine deaminase was initially characterized as pairing with a cofactor, A1CF, to form an active RNA editing complex that specifically targets APOB RNA in regulating lipid metabolism. Recent studies revealed that APOBEC1 may be involved in editing other potential …
APOBEC1 cytosine deaminase was initially characterized as pairing with a cofactor, A1CF, to form an active RNA editing complex that s …
23 results