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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 1
1963 1
1965 1
1969 1
1974 3
1975 3
1976 3
1977 8
1978 9
1979 3
1980 3
1981 4
1982 6
1983 12
1984 7
1985 13
1986 10
1987 11
1988 17
1989 13
1990 7
1991 15
1992 9
1993 11
1994 8
1995 6
1996 12
1997 10
1998 13
1999 25
2000 27
2001 31
2002 27
2003 17
2004 26
2005 26
2006 30
2007 19
2008 26
2009 24
2010 33
2011 38
2012 36
2013 41
2014 50
2015 50
2016 61
2017 57
2018 52
2019 70
2020 98
2021 83
2022 116
2023 99
2024 60

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1,334 results

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A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1beta/NF-kappaB pathway.
Sun C, Cao C, Zhao T, Guo H, Fleming BC, Owens B, Beveridge J, McAllister S, Wei L. Sun C, et al. J Orthop Res. 2023 Jan;41(1):241-248. doi: 10.1002/jor.25348. Epub 2022 May 4. J Orthop Res. 2023. PMID: 35451533 Free article.
Human chondrocytes (cell line C28) were incubated with A2M protein and then treated with IL-1beta. A2M was labeled with VivoTag 680 to localize the protein postincubation. ...IP experiments demonstrated that A2M could bind IL-1beta. Additionally, western blot …
Human chondrocytes (cell line C28) were incubated with A2M protein and then treated with IL-1beta. A2M was labeled with VivoTa …
A2M Serves as Promising Biomarker for Chronic Obstructive Pulmonary Disease.
Xiao X, Cai W, Ding Z, Shi Y, Fan L, Zhang Q. Xiao X, et al. Int J Chron Obstruct Pulmon Dis. 2023 Apr 24;18:683-692. doi: 10.2147/COPD.S407491. eCollection 2023. Int J Chron Obstruct Pulmon Dis. 2023. PMID: 37123074 Free PMC article.
Correlation coefficients were evaluated using Pearson's correlation. RESULTS: Plasma A2M concentration was decreased and MMP-9 concentration, MMP-9/A2M ratio were elevated in stable COPD patients compared with control groups. ...CONCLUSION: A2M is altered in …
Correlation coefficients were evaluated using Pearson's correlation. RESULTS: Plasma A2M concentration was decreased and MMP-9 concen …
LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3.
Qiu X, Shi Q, Zhang X, Shi X, Jiang H, Qin S. Qiu X, et al. Mol Cancer Res. 2022 Nov 3;20(11):1636-1645. doi: 10.1158/1541-7786.MCR-22-0024. Mol Cancer Res. 2022. PMID: 35920801
Moreover, the Erastin-induced ferroptosis increased the expression levels of A2M-AS1. The overexpression of A2M-AS1 promoted ferroptosis in the pancreatic cancer, which was inhibited by the silencing of A2M-AS1. ...IMPLICATIONS: A2M-AS1 might be a pote …
Moreover, the Erastin-induced ferroptosis increased the expression levels of A2M-AS1. The overexpression of A2M-AS1 promoted f …
A2M is a potential core gene in intrahepatic cholangiocarcinoma.
Zhang G, Liu X, Sun Z, Feng X, Wang H, Hao J, Zhang X. Zhang G, et al. BMC Cancer. 2022 Jan 3;22(1):5. doi: 10.1186/s12885-021-09070-2. BMC Cancer. 2022. PMID: 34979994 Free PMC article.
CONCLUSIONS: According to our study, low A2M expression in ICC compared to normal bile duct tissue was an adverse prognostic factor in ICC patients. The value of A2M in the treatment of ICC needs to be further studied....
CONCLUSIONS: According to our study, low A2M expression in ICC compared to normal bile duct tissue was an adverse prognostic factor i …
Inflammatory myofibroblastic tumors of the lung carrying a chimeric A2M-ALK gene: report of 2 infantile cases and review of the differential diagnosis of infantile pulmonary lesions.
Tanaka M, Kohashi K, Kushitani K, Yoshida M, Kurihara S, Kawashima M, Ueda Y, Souzaki R, Kinoshita Y, Oda Y, Takeshima Y, Hiyama E, Taguchi T, Tanaka Y. Tanaka M, et al. Hum Pathol. 2017 Aug;66:177-182. doi: 10.1016/j.humpath.2017.06.013. Epub 2017 Jul 11. Hum Pathol. 2017. PMID: 28705706 Review.
We report 2 infantile cases of pulmonary tumor carrying a chimeric A2M-ALK gene. A2M-ALK is a newly identified anaplastic lymphoma kinase (ALK)-related chimeric gene from a tumor diagnosed as fetal lung interstitial tumor (FLIT). ...The present cases suggest that AL …
We report 2 infantile cases of pulmonary tumor carrying a chimeric A2M-ALK gene. A2M-ALK is a newly identified anaplastic lymp …
LncRNA A2M-AS1 lessens the injury of cardiomyocytes caused by hypoxia and reoxygenation via regulating IL1R2.
Song XL, Zhang FF, Wang WJ, Li XN, Dang Y, Li YX, Yang Q, Shi MJ, Qi XY. Song XL, et al. Genes Genomics. 2020 Dec;42(12):1431-1441. doi: 10.1007/s13258-020-01007-6. Epub 2020 Oct 14. Genes Genomics. 2020. PMID: 33057899
Overexpression of A2M-AS1 can notably enhance the cell viability of H/R-damaged cardiomyocytes, whereas knockdown of A2M-AS1 showed the opposite outcomes. Besides, a negative correlation was showed between A2M-AS1 and IL1R2 expression. In H/R-treated cardiomy …
Overexpression of A2M-AS1 can notably enhance the cell viability of H/R-damaged cardiomyocytes, whereas knockdown of A2M-AS1 s …
Overexpression of lncRNA A2M-AS1 inhibits cell growth and aggressiveness via regulating the miR-587/bone morphogenetic protein 3 axis in lung adenocarcinoma.
Guo H, Li T, Peng C, Mao Q, Shen B, Shi M, Lu H, Xiao T, Yang A, Liu Y. Guo H, et al. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221138971. doi: 10.1177/09603271221138971. Hum Exp Toxicol. 2022. PMID: 36461613 Free article.
However, the precise mechanism of A2M-AS1 in LUAD has not been elucidated. Therefore, our study was designed to investigate the detailed molecular mechanism of A2M-AS1 in LUAD. ...Mechanistically, A2M-AS1 directly bound with miR-587 to promote BMP3 expression …
However, the precise mechanism of A2M-AS1 in LUAD has not been elucidated. Therefore, our study was designed to investigate the detai …
Structural Investigations of Human A2M Identify a Hollow Native Conformation That Underlies Its Distinctive Protease-Trapping Mechanism.
Harwood SL, Lyngsø J, Zarantonello A, Kjøge K, Nielsen PK, Andersen GR, Pedersen JS, Enghild JJ. Harwood SL, et al. Mol Cell Proteomics. 2021;20:100090. doi: 10.1016/j.mcpro.2021.100090. Epub 2021 May 6. Mol Cell Proteomics. 2021. PMID: 33964423 Free PMC article.
A second recombinant A2M introduced an intersubunit disulfide into the LNK region, demonstrating the predicted interactions between these regions in native A2M. Altogether, our native A2M model provides a structural foundation for understanding A2M's p …
A second recombinant A2M introduced an intersubunit disulfide into the LNK region, demonstrating the predicted interactions between t …
Zinc dyshomeostasis, ageing and neurodegeneration: implications of A2M and inflammatory gene polymorphisms.
Mocchegiani E, Malavolta M. Mocchegiani E, et al. J Alzheimers Dis. 2007 Aug;12(1):101-9. doi: 10.3233/jad-2007-12110. J Alzheimers Dis. 2007. PMID: 17851198 Review.
One of the causes may be an altered homeostasis of MT and other zinc-binding proteins, such as alpha2 macroglobulin (A2M), which are of protection against stress and inflammation during young/adult age but turn into being harmful in aging. In fact, despite total brain zinc …
One of the causes may be an altered homeostasis of MT and other zinc-binding proteins, such as alpha2 macroglobulin (A2M), which are …
The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat.
Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, Volke D, Dehghani F, Buzdin A, Engel K, Robitzki A, Hoffmann R, Gockel I, Birkenmeier G. Kurz S, et al. PLoS One. 2017 Dec 27;12(12):e0189514. doi: 10.1371/journal.pone.0189514. eCollection 2017. PLoS One. 2017. PMID: 29281661 Free PMC article.
Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promoting signalling pathways indicating a less tumorigenic environment mediated by A2M. By virtue of these multiple actions the naturally …
Transcriptome analysis of A2M-treated tumour cells, xenografts and mouse liver demonstrated a multifaceted regulation of tumour promo …
1,334 results