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A2ML1 Inhibits Esophageal Squamous Cell Carcinoma Progression and Serves as a Novel Prognostic Biomarker.
Zhang X, Tang C, Lian J, Jiang Y. Zhang X, et al. Can J Gastroenterol Hepatol. 2023 Nov 3;2023:5557546. doi: 10.1155/2023/5557546. eCollection 2023. Can J Gastroenterol Hepatol. 2023. PMID: 37954860 Free PMC article.
Studies have established a correlation between alpha2-macroglobulin-like 1 (A2ML1) and the prognosis of lung, pancreatic, and breast cancers; however, research on its involvement in the pathogenesis of esophageal carcinoma remains limited. ...Our findings demonstrat …
Studies have established a correlation between alpha2-macroglobulin-like 1 (A2ML1) and the prognosis of lung, pancreatic, and breast …
Multi-omics analysis based on integrated genomics, epigenomics and transcriptomics in pancreatic cancer.
Kong L, Liu P, Zheng M, Xue B, Liang K, Tan X. Kong L, et al. Epigenomics. 2020 Mar;12(6):507-524. doi: 10.2217/epi-2019-0374. Epub 2020 Feb 12. Epigenomics. 2020. PMID: 32048534
Aim: Integrated analysis of genomics, epigenomics, transcriptomics and clinical information contributes to identify specific molecular subgroups and find novel biomarkers for pancreatic cancer. Materials & methods: The DNA copy number variation, the simple nucleotide v …
Aim: Integrated analysis of genomics, epigenomics, transcriptomics and clinical information contributes to identify specific molecular subgr …
Detection of autoantibodies against alpha-2-macroglobulin-like 1 in paraneoplastic pemphigus sera utilizing novel green fluorescent protein-based immunoassays.
Bazzini C, Begré N, Favre B, Hashimoto T, Hertl M, Schlapbach C, Borradori L. Bazzini C, et al. J Dermatol Sci. 2020 Jun;98(3):173-178. doi: 10.1016/j.jdermsci.2020.04.005. Epub 2020 May 7. J Dermatol Sci. 2020. PMID: 32439251
OBJECTIVES: To develop novel assays which allow to easily and reliably detect anti-A2ML1 autoantibodies in PNP sera. METHODS: We produced full-length A2ML1 in fusion with enhanced green fluorescent protein (EGFP-A2ML1) in transfected human embryonic kidney 29 …
OBJECTIVES: To develop novel assays which allow to easily and reliably detect anti-A2ML1 autoantibodies in PNP sera. METHODS: We prod …
Anti-α-2-macroglobulin-like-1 autoantibodies are detected frequently and may be pathogenic in paraneoplastic pemphigus.
Numata S, Teye K, Tsuruta D, Sogame R, Ishii N, Koga H, Natsuaki Y, Tsuchisaka A, Hamada T, Karashima T, Nakama T, Furumura M, Ohata C, Kawakami T, Schepens I, Borradori L, Hashimoto T. Numata S, et al. J Invest Dermatol. 2013 Jul;133(7):1785-93. doi: 10.1038/jid.2013.65. Epub 2013 Feb 13. J Invest Dermatol. 2013. PMID: 23407400 Free article.
Next, to investigate the pathogenic role of anti-A2ML1 antibody, we performed additional functional studies. Addition of anti-A2ML1 polyclonal antibody to culture media decreased NHK cell adhesion examined by dissociation assay, and increased plasmin activity detect …
Next, to investigate the pathogenic role of anti-A2ML1 antibody, we performed additional functional studies. Addition of anti-A2ML …
Differentially expressed genes and key molecules of BRCA1/2-mutant breast cancer: evidence from bioinformatics analyses.
Li Y, Zhou X, Liu J, Yin Y, Yuan X, Yang R, Wang Q, Ji J, He Q. Li Y, et al. PeerJ. 2020 Jan 21;8:e8403. doi: 10.7717/peerj.8403. eCollection 2020. PeerJ. 2020. PMID: 31998560 Free PMC article.
BACKGROUND: BRCA1 and BRCA2 genes are currently proven to be closely related to high lifetime risks of breast cancer. To date, the closely related genes to BRCA1/2 mutations in breast cancer remains to be fully elucidated. ...Through topological analysis scores of t …
BACKGROUND: BRCA1 and BRCA2 genes are currently proven to be closely related to high lifetime risks of breast cancer. To date, the cl …
Paraneoplastic autoimmune multiorgan syndrome (PAMS): Beyond the single phenotype of paraneoplastic pemphigus.
Amber KT, Valdebran M, Grando SA. Amber KT, et al. Autoimmun Rev. 2018 Oct;17(10):1002-1010. doi: 10.1016/j.autrev.2018.04.008. Epub 2018 Aug 11. Autoimmun Rev. 2018. PMID: 30103046 Review.
Autoantibodies in PAMS target a wide array of antigens including plakins, cadherins, alpha-2-macroglobulin like 1 (A2ML1), BP180, plakophilin-3, and several neuromuscular antigens. ...
Autoantibodies in PAMS target a wide array of antigens including plakins, cadherins, alpha-2-macroglobulin like 1 (A2ML1), BP180, pla …
Laboratory diagnosis of paraneoplastic pemphigus.
Poot AM, Diercks GF, Kramer D, Schepens I, Klunder G, Hashimoto T, Borradori L, Jonkman MF, Pas HH. Poot AM, et al. Br J Dermatol. 2013 Nov;169(5):1016-24. doi: 10.1111/bjd.12479. Br J Dermatol. 2013. PMID: 23796242
BACKGROUND: Paraneoplastic pemphigus (PNP) is a multiorgan disease characterized by antibodies against plakins, desmogleins and the alpha2-macroglobulin-like-1 (A2ML1) protein, in association with an underlying neoplasm. Accurate diagnosis relies on the demonstration of th …
BACKGROUND: Paraneoplastic pemphigus (PNP) is a multiorgan disease characterized by antibodies against plakins, desmogleins and the alpha2-m …
Clinical and immunological findings in 104 cases of paraneoplastic pemphigus.
Ohzono A, Sogame R, Li X, Teye K, Tsuchisaka A, Numata S, Koga H, Kawakami T, Tsuruta D, Ishii N, Hashimoto T. Ohzono A, et al. Br J Dermatol. 2015 Dec;173(6):1447-52. doi: 10.1111/bjd.14162. Epub 2015 Nov 14. Br J Dermatol. 2015. PMID: 26358412
METHODS: This retrospective study consisted of 104 patients with PNP. Clinical and histopathological manifestations, associated neoplasms, complicating diseases, prognosis and results of immunofluorescence, immunoblotting and enzyme-linked immunosorbent assays (ELISAs) wer …
METHODS: This retrospective study consisted of 104 patients with PNP. Clinical and histopathological manifestations, associated neoplasms …
The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human.
Schepens I, Jaunin F, Begre N, Läderach U, Marcus K, Hashimoto T, Favre B, Borradori L. Schepens I, et al. PLoS One. 2010 Aug 18;5(8):e12250. doi: 10.1371/journal.pone.0012250. PLoS One. 2010. PMID: 20805888 Free PMC article.
BACKGROUND: Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and associated with underlying neoplasms. PNP is characterized by the production of autoantibodies targeting proteins of the plakin and c …
BACKGROUND: Paraneoplastic pemphigus (PNP) is a devastating autoimmune blistering disease, involving mucocutaneous and internal organs, and …
Mining the Biomarkers and Associated-Drugs for Esophageal Squamous Cell Carcinoma by Bioinformatic Methods.
Kuang X, Liu Z. Kuang X, et al. Tohoku J Exp Med. 2022 Jan;256(1):27-36. doi: 10.1620/tjem.256.27. Tohoku J Exp Med. 2022. PMID: 35067492 Free article.
After hub genes validated, nine genes (FLG, COL1A1, COL1A2, PSCA, SCEL, PPL, ACPP, CNFN, and A2ML1) expression trends showed no change. Moreover, higher COL1A1 or COL1A2 expression for ESCC patients showed poor prognosis. ...Probably, these drugs could show anticancer effe …
After hub genes validated, nine genes (FLG, COL1A1, COL1A2, PSCA, SCEL, PPL, ACPP, CNFN, and A2ML1) expression trends showed no chang …
15 results