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1995 1
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2006 2
2007 4
2008 3
2009 6
2010 7
2011 3
2012 7
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95 results

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Page 1
ABI1-based expression signature predicts breast cancer metastasis and survival.
Regua A, Papp C, Grageda A, Porter BA, Caza T, Bichindaritz I, Krendel M, Sivapiragasam A, Bratslavsky G, Kuznetsov VA, Kotula L. Regua A, et al. Mol Oncol. 2022 Jul;16(14):2632-2657. doi: 10.1002/1878-0261.13175. Epub 2022 Jan 26. Mol Oncol. 2022. PMID: 34967509 Free PMC article.
In conclusion, ABI1 is a prognostic metastatic biomarker in breast cancer. We demonstrate, for the first time, that lung metastasis is associated with an Abi1 gene dose and specific gene expression aberrations in primary breast cancer tumors. These res …
In conclusion, ABI1 is a prognostic metastatic biomarker in breast cancer. We demonstrate, for the first time, that lung metas …
PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1.
Qi Y, Liu J, Chao J, Scheuerman MP, Rahimi SA, Lee LY, Li S. Qi Y, et al. Sci Rep. 2020 Jul 29;10(1):12685. doi: 10.1038/s41598-020-69698-1. Sci Rep. 2020. PMID: 32728066 Free PMC article.
The protein rather than the lipid phosphatase activity of PTEN accounts for the reversal of the EMT. PTEN dephosphorylates and downregulates Abi1 in breast cancer cells. Gain- and loss-of-function analysis indicates that upregulation of Abi1 mediates PTEN los …
The protein rather than the lipid phosphatase activity of PTEN accounts for the reversal of the EMT. PTEN dephosphorylates and downregulates …
The roles and prognostic significance of ABI1-TSV-11 expression in patients with left-sided colorectal cancer.
Zhang Y, Zhong Z, Li M, Chen J, Lin T, Sun J, Wang D, Mu Q, Su H, Wu N, Liu A, Yu Y, Zhang M, Liu Y, Guo J, Yu W. Zhang Y, et al. Sci Rep. 2021 May 24;11(1):10734. doi: 10.1038/s41598-021-90220-8. Sci Rep. 2021. PMID: 34031495 Free PMC article.
Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal cancer (CRC). ...Here, we firstly identified ABI1-TSV-11 as a key TSV affecting the metastasis and prognosis of left-sided colo …
Abnormally expressed and/or phosphorylated Abelson interactor 1 (ABI1) participates in the metastasis and progression of colorectal …
Pan-cancer transcriptomic data of ABI1 transcript variants and molecular constitutive elements identifies novel cancer metastatic and prognostic biomarkers.
Lin T, Guo J, Peng Y, Li M, Liu Y, Yu X, Wu N, Yu W. Lin T, et al. Cancer Biomark. 2024;39(1):49-62. doi: 10.3233/CBM-220348. Cancer Biomark. 2024. PMID: 37545215 Free PMC article.
OBJECTIVE: To identify novel cancer metastatic and prognostic biomarkers from ABI1 total mRNA, TSVs, and molecular constitutive elements. ...A total of 13 ABI1 molecular constitutive elements were identified as independent prognostic biomarkers in six canc …
OBJECTIVE: To identify novel cancer metastatic and prognostic biomarkers from ABI1 total mRNA, TSVs, and molecular constitutiv …
Inhibitory short peptides targeting EPS8/ABI1/SOS1 tri-complex suppress invasion and metastasis of ovarian cancer cells.
Yu X, Liang C, Zhang Y, Zhang W, Chen H. Yu X, et al. BMC Cancer. 2019 Sep 5;19(1):878. doi: 10.1186/s12885-019-6087-1. BMC Cancer. 2019. PMID: 31488087 Free PMC article.
RESULTS: The formation of endogenous SOS1/EPS8/ABI1 tri-complex was detected in the event of LPA-induced ovarian cancer cell invasion. ...TAT-p + p-8 peptide could disrupt ABI1-EPS8 interaction and suppress the invasion and metastasis of ovarian cancer …
RESULTS: The formation of endogenous SOS1/EPS8/ABI1 tri-complex was detected in the event of LPA-induced ovarian cancer cell i …
RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.
Maurin M, Ranjouri M, Megino-Luque C, Newberg JY, Du D, Martin K, Miner RE 3rd, Prater MS, Wee DKB, Centeno B, Pruett-Miller SM, Stewart P, Fleming JB, Yu X, Bravo-Cordero JJ, Guccione E, Black MA, Mann KM. Maurin M, et al. Nat Commun. 2023 Dec 19;14(1):8444. doi: 10.1038/s41467-023-44126-w. Nat Commun. 2023. PMID: 38114498 Free PMC article.
RNA splicing is an important biological process associated with cancer initiation and progression. However, the contribution of alternative splicing to pancreatic cancer (PDAC) development is not well understood. ...These exons are differentially spliced in PDAC pat …
RNA splicing is an important biological process associated with cancer initiation and progression. However, the contribution of alter …
Integrity of SOS1/EPS8/ABI1 tri-complex determines ovarian cancer metastasis.
Chen H, Wu X, Pan ZK, Huang S. Chen H, et al. Cancer Res. 2010 Dec 1;70(23):9979-90. doi: 10.1158/0008-5472.CAN-10-2394. Epub 2010 Nov 30. Cancer Res. 2010. PMID: 21118970 Free PMC article.
Importantly, coexpression of SOS1, EPS8, and ABI1, but not of any individual member of SOS1/EPS8/ABI1 tri-complex, correlates with advanced stages and shorter survival of ovarian cancer patients. Our study implicates that the integrity of SOS1/EPS8/ABI1 …
Importantly, coexpression of SOS1, EPS8, and ABI1, but not of any individual member of SOS1/EPS8/ABI1 tri-complex, correlates …
Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling.
Nath D, Li X, Mondragon C, Post D, Chen M, White JR, Hryniewicz-Jankowska A, Caza T, Kuznetsov VA, Hehnly H, Jamaspishvili T, Berman DM, Zhang F, Kung SHY, Fazli L, Gleave ME, Bratslavsky G, Pandolfi PP, Kotula L. Nath D, et al. Cell Commun Signal. 2019 Sep 18;17(1):120. doi: 10.1186/s12964-019-0410-y. Cell Commun Signal. 2019. PMID: 31530281 Free PMC article.
ABI1, a member of WAVE complex and actin cytoskeleton regulator and adaptor protein, acts as tumor suppressor in prostate cancer but the role of ABI1 in EMT is not clear. ...Furthermore, an increase in STAT3 phosphorylation upon ABI1 inactivation and t …
ABI1, a member of WAVE complex and actin cytoskeleton regulator and adaptor protein, acts as tumor suppressor in prostate cancer …
Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.
Kotula L. Kotula L. FEBS Lett. 2012 Aug 14;586(17):2790-4. doi: 10.1016/j.febslet.2012.05.015. Epub 2012 May 19. FEBS Lett. 2012. PMID: 22617151 Free PMC article. Review.
Although PI-3 kinase function has been associated with actin cytoskeleton remodeling, satisfactory explanations of the mechanisms mediating this regulation have been elusive. Here we propose that interaction of the Abi1 protein with the p85 regulatory subunit of PI-3 kinas …
Although PI-3 kinase function has been associated with actin cytoskeleton remodeling, satisfactory explanations of the mechanisms mediating …
Epithelial-mesenchymal transition of ovarian cancer cells is sustained by Rac1 through simultaneous activation of MEK1/2 and Src signaling pathways.
Fang D, Chen H, Zhu JY, Wang W, Teng Y, Ding HF, Jing Q, Su SB, Huang S. Fang D, et al. Oncogene. 2017 Mar;36(11):1546-1558. doi: 10.1038/onc.2016.323. Epub 2016 Sep 12. Oncogene. 2017. PMID: 27617576 Free PMC article.
However, molecular mechanism sustaining EMT of ovarian cancer cells remains elusive. Here we show that the presence of SOS1/EPS8/ABI1 complex is critical for sustained EMT traits of ovarian cancer cells. Consistent with the role of SOS1/EPS8/ABI1 compl …
However, molecular mechanism sustaining EMT of ovarian cancer cells remains elusive. Here we show that the presence of SOS1/EPS8/A …
95 results