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Year Number of Results
2002 1
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2008 8
2009 14
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2011 23
2012 28
2013 33
2014 42
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2016 35
2017 35
2018 26
2019 33
2020 28
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374 results

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Page 1
The Role of ACKR3 in Breast, Lung, and Brain Cancer.
Neves M, Fumagalli A, van den Bor J, Marin P, Smit MJ, Mayor F. Neves M, et al. Mol Pharmacol. 2019 Dec;96(6):819-825. doi: 10.1124/mol.118.115279. Epub 2019 Feb 11. Mol Pharmacol. 2019. PMID: 30745320 Free article. Review.
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3). This atypical chemokine receptor is overexpressed in numerous cancer types and has been involved in the modulation of tumor cel …
Recent reports regarding the significance of chemokine receptors in disease have put a spotlight on atypical chemokine receptor 3 (ACKR3 …
CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications.
Yang Y, Li J, Lei W, Wang H, Ni Y, Liu Y, Yan H, Tian Y, Wang Z, Yang Z, Yang S, Yang Y, Wang Q. Yang Y, et al. Int J Biol Sci. 2023 Jun 26;19(11):3341-3359. doi: 10.7150/ijbs.82317. eCollection 2023. Int J Biol Sci. 2023. PMID: 37497001 Free PMC article. Review.
Cytokines, including chemokines, exhibit expression changes and disorders in all human cancers. These cytokine abnormalities can disrupt homeostasis and immune function, and make outstanding contributions to various stages of cancer development such as invasion, met …
Cytokines, including chemokines, exhibit expression changes and disorders in all human cancers. These cytokine abnormalities can disr …
CXCL12-CXCR4/CXCR7 Axis in Colorectal Cancer: Therapeutic Target in Preclinical and Clinical Studies.
Khare T, Bissonnette M, Khare S. Khare T, et al. Int J Mol Sci. 2021 Jul 9;22(14):7371. doi: 10.3390/ijms22147371. Int J Mol Sci. 2021. PMID: 34298991 Free PMC article. Review.
Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and regulate resistance to chemotherapy. ...The CXCL12-CXCR4 axis is involved in tumor growth, invasion, angiogenesis, and metastasis in colorectal cancer (CRC). CXCR7, recently termed as a …
Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and regulate resistance to chemotherapy. ...The CXCL12-C …
Crosstalk between CXCR4/ACKR3 and EGFR Signaling in Breast Cancer Cells.
Neves M, Marolda V, Mayor F Jr, Penela P. Neves M, et al. Int J Mol Sci. 2022 Oct 6;23(19):11887. doi: 10.3390/ijms231911887. Int J Mol Sci. 2022. PMID: 36233192 Free PMC article.
A better understanding of the complex crosstalk among key receptors and signaling pathways involved in cancer progression is needed to improve current therapies. We have investigated in cell models representative of the major subtypes of breast cancer (BC) the inter …
A better understanding of the complex crosstalk among key receptors and signaling pathways involved in cancer progression is needed t …
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury.
Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke MC, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Beker MC, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer HF, Rath D, Gawaz M. Rohlfing AK, et al. Nat Commun. 2022 Apr 5;13(1):1823. doi: 10.1038/s41467-022-29341-1. Nat Commun. 2022. PMID: 35383158 Free PMC article.
Loss of platelet ACKR3 enhances tissue injury in ischemic myocardium and brain and aggravates tissue inflammation. Activation of platelet-ACKR3 via specific ACKR3 agonists inhibits platelet activation and thrombus formation and attenuates tissue injury in isc …
Loss of platelet ACKR3 enhances tissue injury in ischemic myocardium and brain and aggravates tissue inflammation. Activation of plat …
Ackr3-Venus knock-in mouse lights up brain vasculature.
Ehrlich AT, Semache M, Couvineau P, Wojcik S, Kobayashi H, Thelen M, Gross F, Hogue M, Le Gouill C, Darcq E, Bouvier M, Kieffer BL. Ehrlich AT, et al. Mol Brain. 2021 Sep 28;14(1):151. doi: 10.1186/s13041-021-00862-y. Mol Brain. 2021. PMID: 34583741 Free PMC article.
At present, ACKR3 is considered a target for cancer and cardiovascular disorders, but less is known about the potential of ACKR3 as a target for brain disease. ...In ACKR3-Venus knock-in mice, we found normal ACKR3 mRNA levels in the brain, sugg …
At present, ACKR3 is considered a target for cancer and cardiovascular disorders, but less is known about the potential of …
Targeted Imaging of the Atypical Chemokine Receptor 3 (ACKR3/CXCR7) in Human Cancer Xenografts.
Behnam Azad B, Lisok A, Chatterjee S, Poirier JT, Pullambhatla M, Luker GD, Pomper MG, Nimmagadda S. Behnam Azad B, et al. J Nucl Med. 2016 Jun;57(6):981-8. doi: 10.2967/jnumed.115.167932. Epub 2016 Feb 23. J Nucl Med. 2016. PMID: 26912435 Free PMC article.
METHODS: ACKR3 expression data were extracted from Cancer Cell Line Encyclopedia, The Cancer Genome Atlas, and the Clinical Lung Cancer Genome Project. (89)Zr-ACKR3-mAb was evaluated in vitro and subsequently in vivo by PET and ex vivo biodistri …
METHODS: ACKR3 expression data were extracted from Cancer Cell Line Encyclopedia, The Cancer Genome Atlas, and the Clin …
Effects of Small Molecule Ligands on ACKR3 Receptors.
Hopkins BE, Masuho I, Ren D, Iyamu ID, Lv W, Malik N, Martemyanov KA, Schiltz GE, Miller RJ. Hopkins BE, et al. Mol Pharmacol. 2022 Sep;102(3):128-138. doi: 10.1124/molpharm.121.000295. Epub 2022 Jul 9. Mol Pharmacol. 2022. PMID: 35809897 Free PMC article.
The development of more selective ACKR3 ligands should allow us to better appreciate the unique roles of ACKR3 in the CXCL12/CXCR4/ACKR3-signaling axis and better understand the structural determinants for ACKR3 activation. ...This work will help to be …
The development of more selective ACKR3 ligands should allow us to better appreciate the unique roles of ACKR3 in the CXCL12/C …
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention.
Cambier S, Gouwy M, Proost P. Cambier S, et al. Cell Mol Immunol. 2023 Mar;20(3):217-251. doi: 10.1038/s41423-023-00974-6. Epub 2023 Feb 1. Cell Mol Immunol. 2023. PMID: 36725964 Free PMC article. Review.
Furthermore, (hetero)dimerization and tight regulation of transcription and translation, as well as post-translational modifications further fine-tune the spatial and temporal activity of CXCL8 in the context of inflammatory diseases and cancer. The CXCL8 interaction with …
Furthermore, (hetero)dimerization and tight regulation of transcription and translation, as well as post-translational modifications further …
Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12.
Del Molino Del Barrio I, Wilkins GC, Meeson A, Ali S, Kirby JA. Del Molino Del Barrio I, et al. Int J Mol Sci. 2018 Nov 14;19(11):3592. doi: 10.3390/ijms19113592. Int J Mol Sci. 2018. PMID: 30441765 Free PMC article.
Upon binding with the chemokine CXCL12, the chemokine receptor CXCR4 has been shown to promote breast cancer progression. This process, however, can be affected by the expression of the atypical chemokine receptor ACKR3. ...Functional consequences in cell migration …
Upon binding with the chemokine CXCL12, the chemokine receptor CXCR4 has been shown to promote breast cancer progression. This proces …
374 results