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Oncogenic ACSM1 in prostate cancer is through metabolic and extracellular matrix-receptor interaction signaling pathways.
Guo Y, Ren C, Huang W, Yang W, Bao Y. Guo Y, et al. Am J Cancer Res. 2022 Apr 15;12(4):1824-1842. eCollection 2022. Am J Cancer Res. 2022. PMID: 35530294 Free PMC article.
However, ACSM1 gene amplifications were significantly corrected with increased risks of prostate cancer metastasis, and ACSM1 genetic alterations were significantly associated with worse disease-free. ...In conclusion, the present work has demonstrated that …
However, ACSM1 gene amplifications were significantly corrected with increased risks of prostate cancer metastasis, and ACS …
ACSM1 and ACSM3 regulate fatty acid metabolism to support prostate cancer growth and constrain ferroptosis.
Shrestha RK, Nassar ZD, Hanson AR, Iggo R, Townley SL, Dehairs J, Mah CY, Helm M, Alizadeh-Ghodsi M, Pickering M, Ghesquiere B, Watt MJ, Quek LE, Hoy AJ, Tilley WD, Swinnen JV, Butler LM, Selth LA. Shrestha RK, et al. Cancer Res. 2024 Apr 24. doi: 10.1158/0008-5472.CAN-23-1489. Online ahead of print. Cancer Res. 2024. PMID: 38657108
ACSM1 and ACSM3 were upregulated in prostate tumors compared to non-malignant tissues and other cancer types. ...ACSM1 and ACSM3 were major regulators of the prostate cancer lipidome and enhanced energy production via fatty acid oxidation. ...
ACSM1 and ACSM3 were upregulated in prostate tumors compared to non-malignant tissues and other cancer types. ...ACSM1 …
Comprehensive Analysis of Purine-Metabolism-Related Gene Signature for Predicting Ovarian Cancer Prognosis, Immune Landscape, and Potential Treatment Options.
Liu J, Zhang X, Wang H, Zuo X, Hong L. Liu J, et al. J Pers Med. 2023 Apr 29;13(5):776. doi: 10.3390/jpm13050776. J Pers Med. 2023. PMID: 37240946 Free PMC article.
Purine metabolism is an important branch of metabolic reprogramming and has received increasing attention in cancer research. Ovarian cancer is an extremely dangerous gynecologic malignancy for which there are no adequate tools to predict prognostic risk. ...In addi …
Purine metabolism is an important branch of metabolic reprogramming and has received increasing attention in cancer research. Ovarian …
Poldip2 is an oxygen-sensitive protein that controls PDH and alphaKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.
Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, Torres G, Sanhueza-Olivares F, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A. Paredes F, et al. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1789-1794. doi: 10.1073/pnas.1720693115. Epub 2018 Feb 6. Proc Natl Acad Sci U S A. 2018. PMID: 29434038 Free PMC article.
ACSM1 is required for the utilization of lipoic acid derived from a salvage pathway, an unacknowledged lipoylation mechanism. ...Increasing mitochondrial lipoylation by forced expression of Poldip2 increases respiration and reduces the growth rate of cancer cells. O …
ACSM1 is required for the utilization of lipoic acid derived from a salvage pathway, an unacknowledged lipoylation mechanism. ...Incr …
Prostate Cancer Risk Stratification in Men With a Clinical Suspicion of Prostate Cancer Using a Unique Biparametric MRI and Expression of 11 Genes in Apparently Benign Tissue: Evaluation Using Machine-Learning Techniques.
Montoya Perez I, Jambor I, Pahikkala T, Airola A, Merisaari H, Saunavaara J, Alinezhad S, Väänänen RM, Tallgrén T, Verho J, Kiviniemi A, Ettala O, Knaapila J, Syvänen KT, Kallajoki M, Vainio P, Aronen HJ, Pettersson K, Boström PJ, Taimen P. Montoya Perez I, et al. J Magn Reson Imaging. 2020 May;51(5):1540-1553. doi: 10.1002/jmri.26945. Epub 2019 Oct 6. J Magn Reson Imaging. 2020. PMID: 31588660 Clinical Trial.
BACKGROUND: Accurate risk stratification of men with a clinical suspicion of prostate cancer (cSPCa) remains challenging despite the increasing use of MRI. ...Additionally, 2-core from normal-appearing prostate areas were obtained for the mRNA expression of ACSM1, A …
BACKGROUND: Accurate risk stratification of men with a clinical suspicion of prostate cancer (cSPCa) remains challenging despite the …
Molecular characterization of apocrine carcinoma of the breast: validation of an apocrine protein signature in a well-defined cohort.
Celis JE, Cabezón T, Moreira JM, Gromov P, Gromova I, Timmermans-Wielenga V, Iwase T, Akiyama F, Honma N, Rank F. Celis JE, et al. Mol Oncol. 2009 Jun;3(3):220-37. doi: 10.1016/j.molonc.2009.01.005. Epub 2009 Feb 3. Mol Oncol. 2009. PMID: 19393583 Free PMC article.
Establishing these apocrine-specific markers as best practice for the routine pathology evaluation of breast cancer, however, will require their validation in large cohorts of patients. ...These results pave the way for addressing issues such as prognosis of IACs, patient …
Establishing these apocrine-specific markers as best practice for the routine pathology evaluation of breast cancer, however, will re …
15-prostaglandin dehydrogenase expression alone or in combination with ACSM1 defines a subgroup of the apocrine molecular subtype of breast carcinoma.
Celis JE, Gromov P, Cabezón T, Moreira JM, Friis E, Jirström K, Llombart-Bosch A, Timmermans-Wielenga V, Rank F, Gromova I. Celis JE, et al. Mol Cell Proteomics. 2008 Oct;7(10):1795-809. doi: 10.1074/mcp.R800011-MCP200. Epub 2008 Jul 16. Mol Cell Proteomics. 2008. PMID: 18632593 Free article.
Here we reiterate our strategy to reveal apocrine cell markers and present novel data, based on the analysis of a considerably larger number of samples, establishing that IACs correspond to a distinct molecular subtype of breast carcinomas characterized by the expression of 15-pr …
Here we reiterate our strategy to reveal apocrine cell markers and present novel data, based on the analysis of a considerably larger number …
Stratification of aggressive prostate cancer from indolent disease-Prospective controlled trial utilizing expression of 11 genes in apparently benign tissue.
Alinezhad S, Väänänen RM, Tallgrén T, Perez IM, Jambor I, Aronen H, Kähkönen E, Ettala O, Syvänen K, Nees M, Kallajoki M, Taimen P, Boström PJ, Pettersson K. Alinezhad S, et al. Urol Oncol. 2016 Jun;34(6):255.e15-22. doi: 10.1016/j.urolonc.2015.12.014. Epub 2016 Feb 5. Urol Oncol. 2016. PMID: 26857646 Clinical Trial.
BACKGROUND: The aim of the study was to evaluate the diagnostic power of molecular markers in men with a clinical suspicion of prostate cancer (PCa) using apparently benign areas as targeted by magnetic resonance imaging (MRI). ...In addition to 12-core systematic and MRI- …
BACKGROUND: The aim of the study was to evaluate the diagnostic power of molecular markers in men with a clinical suspicion of prostate c …
Validation of Novel Biomarkers for Prostate Cancer Progression by the Combination of Bioinformatics, Clinical and Functional Studies.
Alinezhad S, Väänänen RM, Mattsson J, Li Y, Tallgrén T, Tong Ochoa N, Bjartell A, Åkerfelt M, Taimen P, Boström PJ, Pettersson K, Nees M. Alinezhad S, et al. PLoS One. 2016 May 19;11(5):e0155901. doi: 10.1371/journal.pone.0155901. eCollection 2016. PLoS One. 2016. PMID: 27196083 Free PMC article.
The identification and validation of biomarkers for clinical applications remains an important issue for improving diagnostics and therapy in many diseases, including prostate cancer. Gene expression profiles are routinely applied to identify diagnostic and predictive biom …
The identification and validation of biomarkers for clinical applications remains an important issue for improving diagnostics and therapy i …
New network topology approaches reveal differential correlation patterns in breast cancer.
Bockmayr M, Klauschen F, Györffy B, Denkert C, Budczies J. Bockmayr M, et al. BMC Syst Biol. 2013 Aug 15;7:78. doi: 10.1186/1752-0509-7-78. BMC Syst Biol. 2013. PMID: 23945349 Free PMC article.
Clusters of differentially correlated genes could be interpreted biologically and included the marker genes hydroxyprostaglandin dehydrogenase (PGDH) and acyl-CoA synthetase medium chain 1 (ACSM1) of invasive apocrine carcinomas that were differentially correlated, but not …
Clusters of differentially correlated genes could be interpreted biologically and included the marker genes hydroxyprostaglandin dehydrogena …
11 results