Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 2
2007 1
2008 1
2009 2
2010 1
2012 3
2013 2
2014 1
2015 5
2016 6
2017 6
2018 9
2019 10
2020 3
2021 5
2022 6
2023 7
2024 5

Text availability

Article attribute

Article type

Publication date

Search Results

63 results

Results by year

Filters applied: . Clear all
Page 1
Investigation of the Clinical Significance and Prognostic Value of the lncRNA ACVR2B-As1 in Liver Cancer.
Nie Y, Jiao Y, Li Y, Li W. Nie Y, et al. Biomed Res Int. 2019 Oct 30;2019:4602371. doi: 10.1155/2019/4602371. eCollection 2019. Biomed Res Int. 2019. PMID: 31886217 Free PMC article.
Herein, we analyzed RNA-seq data from the TCGA database and identified a newly annotated lncRNA, ACVR2B-AS1, whose expression is upregulated in liver cancer. Higher ACVR2B-AS1 expression is an independent adverse prognostic factor for overall survival (OS) an …
Herein, we analyzed RNA-seq data from the TCGA database and identified a newly annotated lncRNA, ACVR2B-AS1, whose expression is upre …
ACVR2B antagonism as a countermeasure to multi-organ perturbations in metastatic colorectal cancer cachexia.
Huot JR, Pin F, Narasimhan A, Novinger LJ, Keith AS, Zimmers TA, Willis MS, Bonetto A. Huot JR, et al. J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1779-1798. doi: 10.1002/jcsm.12642. Epub 2020 Nov 16. J Cachexia Sarcopenia Muscle. 2020. PMID: 33200567 Free PMC article.
Activin receptor type 2B (ACVR2B) signalling is known to cause SKM wasting, and its inhibition restores SKM mass and prolongs survival in cancer. ...Altogether, our observations implicate ACVR2B signalling in the development of multi-organ perturbations in me …
Activin receptor type 2B (ACVR2B) signalling is known to cause SKM wasting, and its inhibition restores SKM mass and prolongs surviva …
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs.
Rodgers BD, Ward CW. Rodgers BD, et al. Endocr Rev. 2022 Mar 9;43(2):329-365. doi: 10.1210/endrev/bnab030. Endocr Rev. 2022. PMID: 34520530 Free PMC article. Review.
As a comorbidity, muscle wasting is associated with different neuromuscular diseases and myopathies, cancer, heart failure, chronic pulmonary and renal diseases, peripheral neuropathies, inflammatory disorders, and, of course, musculoskeletal injuries. ...
As a comorbidity, muscle wasting is associated with different neuromuscular diseases and myopathies, cancer, heart failure, chronic p …
Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.
Monsivais D, Nagashima T, Prunskaite-Hyyryläinen R, Nozawa K, Shimada K, Tang S, Hamor C, Agno JE, Chen F, Masand RP, Young SL, Creighton CJ, DeMayo FJ, Ikawa M, Lee SJ, Matzuk MM. Monsivais D, et al. Nat Commun. 2021 Jun 7;12(1):3386. doi: 10.1038/s41467-021-23571-5. Nat Commun. 2021. PMID: 34099644 Free PMC article.
Mice were generated to contain single or double conditional deletion of SMAD1/5 and ACVR2A/ACVR2B receptors using progesterone receptor (PR)-cre. Female mice with SMAD1/5 deletion display endometrial defects that result in the development of cystic endometrial glands, a hy …
Mice were generated to contain single or double conditional deletion of SMAD1/5 and ACVR2A/ACVR2B receptors using progesterone recept …
Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.
Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R. Magga J, et al. Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24. Mol Ther. 2019. PMID: 30765322 Free PMC article.
Systemic blockade of ACVR2B ligands by ACVR2B-Fc was protective against cardiac IR injury, as evidenced by reduced infarcted area, apoptosis, and autophagy and better preserved LV systolic function following IR. ...ACVR2B ligand myostatin was found to exacerb …
Systemic blockade of ACVR2B ligands by ACVR2B-Fc was protective against cardiac IR injury, as evidenced by reduced infarcted a …
Autoantibodies in the diagnosis, prognosis, and prediction of colorectal cancer.
Niloofa R, De Zoysa MI, Seneviratne LS. Niloofa R, et al. J Cancer Res Ther. 2021 Jul-Sep;17(4):819-833. doi: 10.4103/jcrt.JCRT_64_19. J Cancer Res Ther. 2021. PMID: 34528528 Free article. Review.
Colorectal cancer (CRC) is the second-most commonly diagnosed cancer worldwide. ...When tested in combination, autoantibodies against three antigens (PIM1, MAPKAPK3, and ACVR2B) showed high sensitivity and specificity. So far, most CRC-associated autoantibodi …
Colorectal cancer (CRC) is the second-most commonly diagnosed cancer worldwide. ...When tested in combination, autoantibodies …
Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.
Zhong X, Narasimhan A, Silverman LM, Young AR, Shahda S, Liu S, Wan J, Liu Y, Koniaris LG, Zimmers TA. Zhong X, et al. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2146-2161. doi: 10.1002/jcsm.12998. Epub 2022 May 5. J Cachexia Sarcopenia Muscle. 2022. PMID: 35510530 Free PMC article.
The reproductive hormone and cytokine Activin is a mediator of PDAC cachexia, and Activin receptor targeting was clinically tested for cancer cachexia therapy. However, sex-specific manifestations and mechanisms are poorly understood, constraining development of effective …
The reproductive hormone and cytokine Activin is a mediator of PDAC cachexia, and Activin receptor targeting was clinically tested for ca …
ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass.
Barreto R, Kitase Y, Matsumoto T, Pin F, Colston KC, Couch KE, O'Connell TM, Couch ME, Bonewald LF, Bonetto A. Barreto R, et al. Sci Rep. 2017 Oct 31;7(1):14470. doi: 10.1038/s41598-017-15040-1. Sci Rep. 2017. PMID: 29089584 Free PMC article.
ACVR2B/Fc prevented the loss of muscle mass and strength, and the loss of trabecular bone in femurs and vertebrae following Folfiri administration. ...Our results suggest that Folfiri is responsible for concomitant muscle and bone degeneration, and that ACVR2B/Fc pr …
ACVR2B/Fc prevented the loss of muscle mass and strength, and the loss of trabecular bone in femurs and vertebrae following Folfiri a …
Genetic Variant in ACVR2B Is Associated with Lean Mass.
Klimentidis YC, Bea JW, Thompson P, Klimecki WT, Hu C, Wu G, Nicholas JS, Ryckman KK, Chen Z. Klimentidis YC, et al. Med Sci Sports Exerc. 2016 Jul;48(7):1270-5. doi: 10.1249/MSS.0000000000000889. Med Sci Sports Exerc. 2016. PMID: 26848890 Free PMC article.
In the replication stage, we find that SNP rs2276541 in the activin A receptor, type IIB (ACVR2B), was significantly associated with LM (beta = 0.15, P = 2.17 10). ...CONCLUSIONS: Our findings support a previously proposed role of ACVR2B allelic variation as a deter …
In the replication stage, we find that SNP rs2276541 in the activin A receptor, type IIB (ACVR2B), was significantly associated with …
Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses.
Nissinen TA, Hentilä J, Penna F, Lampinen A, Lautaoja JH, Fachada V, Holopainen T, Ritvos O, Kivelä R, Hulmi JJ. Nissinen TA, et al. J Cachexia Sarcopenia Muscle. 2018 Jun;9(3):514-529. doi: 10.1002/jcsm.12310. Epub 2018 May 2. J Cachexia Sarcopenia Muscle. 2018. PMID: 29722201 Free PMC article.
BACKGROUND: Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in experimental cancer. ...METHODS: The effects of blocking activin receptor type 2 (ACVR2) ligands on both muscle and non-muscle tissues we …
BACKGROUND: Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in expe …
63 results