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ADAMTS19 Suppresses Cell Migration and Invasion by Targeting S100A16 via the NF-kappaB Pathway in Human Gastric Cancer.
Jiang Y, Yu X, Zhao Y, Huang J, Li T, Chen H, Zhou J, Huang Z, Yang Z. Jiang Y, et al. Biomolecules. 2021 Apr 12;11(4):561. doi: 10.3390/biom11040561. Biomolecules. 2021. PMID: 33921267 Free PMC article.
A Disintegrin and Metalloproteinase with Thrombospondin motifs 19 (ADAMTS19) has been reported to participate in the pathogenesis of solid cancers. ...S100A16 acted as the downstream of ADAMTS19, reversing the suppression of cell migration and invasion by …
A Disintegrin and Metalloproteinase with Thrombospondin motifs 19 (ADAMTS19) has been reported to participate in the pathogenesis of …
Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer.
Alonso S, González B, Ruiz-Larroya T, Durán Domínguez M, Kato T, Matsunaga A, Suzuki K, Strongin AY, Gimènez-Bonafé P, Perucho M. Alonso S, et al. Clin Epigenetics. 2015 Dec 2;7:124. doi: 10.1186/s13148-015-0158-1. eCollection 2015. Clin Epigenetics. 2015. PMID: 26634009 Free PMC article.
Tumor-specific methylation of ADAMTS19 was significantly more frequent in gastrointestinal than in gynecological cancers (odds ratio (OR) = 2.9, confidence interval (CI) = (1.9-4.7), p = 5.2 10(-7)) and was independent of the methylation of adjacent loci in CRC. ... …
Tumor-specific methylation of ADAMTS19 was significantly more frequent in gastrointestinal than in gynecological cancers (odds …
Clinical Significance of ADAMTS19, BMP7, SIM1, and SFRP1 Promoter Methylation in Renal Clear Cell Carcinoma.
Kubiliute R, Zalimas A, Bakavicius A, Ulys A, Jankevicius F, Jarmalaite S. Kubiliute R, et al. Onco Targets Ther. 2021 Oct 5;14:4979-4990. doi: 10.2147/OTT.S330341. eCollection 2021. Onco Targets Ther. 2021. PMID: 34675538 Free PMC article.
RESULTS: DNA methylation changes of ADAMTS19, BMP7, SIM1, and SFRP1 were cancer-specific with significantly (P<0.050) higher methylation frequency (37%, 20%, 18%, and 42%, respectively) in tumor tissues. ...CONCLUSION: In conclusion, DNA methylation of the three- …
RESULTS: DNA methylation changes of ADAMTS19, BMP7, SIM1, and SFRP1 were cancer-specific with significantly (P<0.050) highe …
Concurrent mutations associated with trastuzumab-resistance revealed by single cell sequencing.
Gao Y, Wu N, Wang S, Yang X, Wang X, Xu B. Gao Y, et al. Breast Cancer Res Treat. 2021 Jun;187(3):613-624. doi: 10.1007/s10549-021-06237-0. Epub 2021 Apr 27. Breast Cancer Res Treat. 2021. PMID: 33905021
PURPOSE: HER2-positive breast cancer patients benefit from HER2-targeted therapies, among which the most commonly used is trastuzumab. ...CONCLUSION: Taken together, our study revealed a common pathway level trastuzumab-resistance mechanism for HER2-positive breast canc …
PURPOSE: HER2-positive breast cancer patients benefit from HER2-targeted therapies, among which the most commonly used is trastuzumab …
The Endometrial Transcriptome of Metabolic and Inflammatory Pathways During the Window of Implantation Is Deranged in Infertile Obese Polycystic Ovarian Syndrome Women.
Salamun V, Rizzo M, Lovrecic L, Hocevar K, Papler Burnik T, Janez A, Jensterle M, Vrtacnik Bokal E, Peterlin B, Maver A. Salamun V, et al. Metab Syndr Relat Disord. 2022 Sep;20(7):384-394. doi: 10.1089/met.2021.0149. Epub 2022 Jul 13. Metab Syndr Relat Disord. 2022. PMID: 35834645
Results: Infertile O-PCOS patients had 610 differentially expressed genes (DEGs), after adjustment for multiple comparisons with normal weight infertile controls, related to obesity (MXRA5 and ECM1), PCOS (ADAMTS19 and SLC18A2), and metabolism (VNN1 and PC). In the ovulato …
Results: Infertile O-PCOS patients had 610 differentially expressed genes (DEGs), after adjustment for multiple comparisons with normal weig …
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
Cal S, Obaya AJ, Llamazares M, Garabaya C, Quesada V, López-Otín C. Cal S, et al. Gene. 2002 Jan 23;283(1-2):49-62. doi: 10.1016/s0378-1119(01)00861-7. Gene. 2002. PMID: 11867212
ADAMTS (A Disintegrin And Metalloproteinase domain, with ThromboSpondin type-1 modules) is a recently described family of zinc-dependent proteases which play important roles in a variety of normal and pathological conditions, including arthritis and cancer. In this work, w …
ADAMTS (A Disintegrin And Metalloproteinase domain, with ThromboSpondin type-1 modules) is a recently described family of zinc-dependent pro …
Key pathway and gene alterations in the gastric mucosa associated with obesity and obesity-related diabetes.
Wen X, Qian C, Zhang Y, Wu R, Lu L, Zhu C, Cheng X, Cui R, You H, Mei F, Gao J, Li F, Bu L, Qu S. Wen X, et al. J Cell Biochem. 2019 Apr;120(4):6763-6771. doi: 10.1002/jcb.27976. Epub 2018 Nov 18. J Cell Biochem. 2019. PMID: 30450618
Seven differentially expressed genes were validated by RT-PCR (NRIP3, L1CAM, TPO, P2RY1, OR8A1, ADAMTS19, and ASIC3). A functional analysis revealed that genes differentially expressed between the OB or OD and CON groups played crucial roles in metabolic, T cell, and G-pro …
Seven differentially expressed genes were validated by RT-PCR (NRIP3, L1CAM, TPO, P2RY1, OR8A1, ADAMTS19, and ASIC3). A functional an …
Comparing MitoQ10 and heat therapy: Evaluating mechanisms and therapeutic potential for polycystic ovary syndrome induced by circadian rhythm disruption.
Amin SN, Asali F, Aolymat I, Abuquteish D, Abu Al Karsaneh O, El Gazzar WB, Shaltout SA, Alabdallat YJ, Elberry DA, Kamar SS, Hosny SA, Mehesen MN, Rashed LA, Farag AM, ShamsEldeen AM. Amin SN, et al. Chronobiol Int. 2023 Aug;40(8):1004-1027. doi: 10.1080/07420528.2023.2241902. Epub 2023 Aug 7. Chronobiol Int. 2023. PMID: 37548004