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Pan-Cancer Analysis Identifies Tumor Cell Surface Targets for CAR-T Cell Therapies and Antibody Drug Conjugates.
Li X, Zhou J, Zhang W, You W, Wang J, Zhou L, Liu L, Chen WW, Li H. Li X, et al. Cancers (Basel). 2022 Nov 18;14(22):5674. doi: 10.3390/cancers14225674. Cancers (Basel). 2022. PMID: 36428765 Free PMC article.
In this study, we aimed to identify novel tumor-specific antigens as targets for more effective and safer CAR-T cell therapies and ADCs. Here, we performed differential expression analysis of pan-cancer data obtained from the Cancer Genome Atlas (TCGA), and then per …
In this study, we aimed to identify novel tumor-specific antigens as targets for more effective and safer CAR-T cell therapies and ADCs. Her …
MiR-218 suppresses metastasis and invasion of endometrial cancer via negatively regulating ADD2.
Li XC, Hai JJ, Tan YJ, Yue QF, Liu LJ. Li XC, et al. Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1408-1417. doi: 10.26355/eurrev_201902_17097. Eur Rev Med Pharmacol Sci. 2019. PMID: 30840261 Free article.
OBJECTIVE: Endometrial cancer (EC) is one of the three most common gynecological cancers. ...Rescue experiments further validated that miR-218 could serve as a carcinoma suppressor by negatively regulating ADD2 expression in EC. CONCLUSIONS: In the present st …
OBJECTIVE: Endometrial cancer (EC) is one of the three most common gynecological cancers. ...Rescue experiments further valida …
Discovery and Validation of Hypermethylated Markers for Colorectal Cancer.
Wei J, Li G, Dang S, Zhou Y, Zeng K, Liu M. Wei J, et al. Dis Markers. 2016;2016:2192853. doi: 10.1155/2016/2192853. Epub 2016 Jul 14. Dis Markers. 2016. PMID: 27493446 Free PMC article.
ROC curves show that the areas under the curves of ADD2 and AKR1B1 are higher than that of SEPT9, which has been clinically used as a screening biomarker of CRC. Our data suggests that aberrant DNA methylation of ADD2 and AKR1B1 could be potential screening markers …
ROC curves show that the areas under the curves of ADD2 and AKR1B1 are higher than that of SEPT9, which has been clinically used as a …
A Review on Adducin from Functional to Pathological Mechanisms: Future Direction in Cancer.
Kiang KM, Leung GK. Kiang KM, et al. Biomed Res Int. 2018 May 16;2018:3465929. doi: 10.1155/2018/3465929. eCollection 2018. Biomed Res Int. 2018. PMID: 29862265 Free PMC article. Review.
Adducin (ADD) is a family of membrane skeleton proteins including ADD1, ADD2, and ADD3 that are encoded by distinct genes on different chromosomes. ...These alterations are associated with a wide range of diseases including cancer. This paper begins with a discussio …
Adducin (ADD) is a family of membrane skeleton proteins including ADD1, ADD2, and ADD3 that are encoded by distinct genes on differen …
Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2.
Yenerel MN, Sundell IB, Weese J, Bulger M, Gilligan DM. Yenerel MN, et al. Exp Hematol. 2005 Jul;33(7):758-66. doi: 10.1016/j.exphem.2005.03.015. Exp Hematol. 2005. PMID: 15963851 Free article.
OBJECTIVE: The first objective of this study was to examine the differences in levels of adducin (ADD1, ADD2, ADD3) mRNA expression during human erythropoiesis. The second objective was to determine whether the rapid induction of ADD2 expression could be attributed …
OBJECTIVE: The first objective of this study was to examine the differences in levels of adducin (ADD1, ADD2, ADD3) mRNA expression d …
Transcriptional Control of Gene Expression and the Heterogeneous Cellular Identity of Erythroblastic Island Macrophages.
Mukherjee K, Bieker JJ. Mukherjee K, et al. Front Genet. 2021 Nov 22;12:756028. doi: 10.3389/fgene.2021.756028. eCollection 2021. Front Genet. 2021. PMID: 34880902 Free PMC article. Review.
Specifically, the discovery of markers such as Epor, and specific features for EKLF/Klf1-expressing island macrophages such as Sptb and Add2, or for SpiC-expressing island macrophage such as Timd4, or for Maf/Nr1h3-expressing island macrophage such as Vcam1, opens exciting …
Specifically, the discovery of markers such as Epor, and specific features for EKLF/Klf1-expressing island macrophages such as Sptb and A …
Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression.
Lechuga S, Amin PH, Wolen AR, Ivanov AI. Lechuga S, et al. Biochim Biophys Acta Mol Cell Res. 2019 Mar;1866(3):395-408. doi: 10.1016/j.bbamcr.2018.10.001. Epub 2018 Oct 2. Biochim Biophys Acta Mol Cell Res. 2019. PMID: 30290240 Free PMC article.
This study investigated the roles of alpha-adducin (ADD1) and gamma-adducin (ADD3) in regulating migration and invasion of non-small cell lung cancer (NSCLC) cells. ADD1 was mislocalized, whereas ADD3 was markedly downregulated in NSCLC cells with the invasive mesenchymal …
This study investigated the roles of alpha-adducin (ADD1) and gamma-adducin (ADD3) in regulating migration and invasion of non-small cell lu …
Integrative 3' Untranslated Region-Based Model to Identify Patients with Low Risk of Axillary Lymph Node Metastasis in Operable Triple-Negative Breast Cancer.
Wang L, Hu X, Wang P, Shao ZM. Wang L, et al. Oncologist. 2019 Jan;24(1):22-30. doi: 10.1634/theoncologist.2017-0609. Epub 2018 Aug 6. Oncologist. 2019. PMID: 30082491 Free PMC article.
BACKGROUND: Sentinel lymph node biopsy is the standard surgical staging approach for operable triple-negative breast cancer (TNBC) with clinically negative axillae. In this study, we sought to develop a model to predict TNBC patients with negative nodal involvement, who wo …
BACKGROUND: Sentinel lymph node biopsy is the standard surgical staging approach for operable triple-negative breast cancer (TNBC) wi …
The chromosomal translocation (11;14) (p13; q11) in acute B-Cell lymphocytic leukemia.
Miao K, Li J, Qiu H, Zhang R, Chen L, Wu H, Wang R, Zhang J. Miao K, et al. Onkologie. 2010;33(7):385-7. doi: 10.1159/000315753. Epub 2010 Jun 22. Onkologie. 2010. PMID: 20631486
Conventional cytogenetic study by R-banding showed complex chromosome aberrations involving t(11;14)(p13;q11) with the following karyotype: 46,XY,t (11;14)(p13;q11)[2]/46,idem,add2(q?)[2]/46,XY,add16(p?) [3]/46,XY[13]. Fluorescence in situ hybridization analysis indicated …
Conventional cytogenetic study by R-banding showed complex chromosome aberrations involving t(11;14)(p13;q11) with the following karyotype: …
Gastrodin synergistically increases migration of interleukin-13 receptor α2 chimeric antigen receptor T cell to the brain against glioblastoma multiforme: A preclinical study.
Huang S, Bai Y, An Z, Xu C, Zhang C, Wang F, Zhong C, Zhong X. Huang S, et al. Phytother Res. 2023 Dec;37(12):5947-5957. doi: 10.1002/ptr.8007. Epub 2023 Sep 25. Phytother Res. 2023. PMID: 37748098
Transcriptomic analysis revealed that genes related to skeletal migration such as add2 and gng8 showed increased expression in GAS-treated CAR-T cells. ...
Transcriptomic analysis revealed that genes related to skeletal migration such as add2 and gng8 showed increased expression in GAS-tr …
11 results