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Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis and clinical data from The Cancer Genome Atlas.
Zhang Y, Luo J, Liu Z, Liu X, Ma Y, Zhang B, Chen Y, Li X, Feng Z, Yang N, Feng D, Wang L, Song X. Zhang Y, et al. Biosci Rep. 2021 Jul 30;41(7):BSR20211280. doi: 10.1042/BSR20211280. Biosci Rep. 2021. PMID: 34308980 Free PMC article.
Colorectal cancer (CRC) is one of the most common tumors worldwide and is associated with high mortality. ...Weighted gene co-expression network analysis (WGCNA) identified eight gene modules that were associated with clinical characteristics of CRC patients, including bro …
Colorectal cancer (CRC) is one of the most common tumors worldwide and is associated with high mortality. ...Weighted gene co-express …
Generation and initial characterization of mice lacking full-length BAI3 (ADGRB3) expression.
Shiu FH, Wong JC, Bhattacharya D, Kuranaga Y, Parag RR, Alsharif HA, Bhatnagar S, Van Meir EG, Escayg A. Shiu FH, et al. Basic Clin Pharmacol Toxicol. 2023 Oct;133(4):353-363. doi: 10.1111/bcpt.13917. Epub 2023 Jul 7. Basic Clin Pharmacol Toxicol. 2023. PMID: 37337931 Free PMC article.
It is most highly expressed in the brain where it plays a role in synaptogenesis and synapse maintenance. Genome-wide association studies have implicated ADGRB3 in disorders such as schizophrenia and epilepsy. Somatic mutations in ADGRB3 have also been identified in …
It is most highly expressed in the brain where it plays a role in synaptogenesis and synapse maintenance. Genome-wide association studies ha …
NLRC5 Might Promote Endometrial Cancer Progression by Inducing PD-L1 Expression.
Zhu SD, Zhang J, Liu XJ, Zhang JH, Wei B, Wang WY, Fan YJ, Li D, Cao YX, Zhan L. Zhu SD, et al. Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221112742. doi: 10.1177/15330338221112742. Technol Cancer Res Treat. 2022. PMID: 35880269 Free PMC article.
Conclusion: NLRC5 could inhibit the activation of PD-L1 in EC. Mutations of ANKRD20A2, C2orf42, ADGRB3, AVPR2, GOLGA6C, and IPPK may lead to the downregulation of NLRC5 in EC patients. Future study should investigate the mechanism of NLRC5 in PD-L1, as well as the mechanis …
Conclusion: NLRC5 could inhibit the activation of PD-L1 in EC. Mutations of ANKRD20A2, C2orf42, ADGRB3, AVPR2, GOLGA6C, and IPPK may …
A correlation study of adhesion G protein-coupled receptors as potential therapeutic targets in Uterine Corpus Endometrial cancer.
Lei P, Wang H, Yu L, Xu C, Sun H, Lyu Y, Li L, Zhang DL. Lei P, et al. Int Immunopharmacol. 2022 Jul;108:108743. doi: 10.1016/j.intimp.2022.108743. Epub 2022 Apr 9. Int Immunopharmacol. 2022. PMID: 35413679
The structure, function, and involvement of adhesion GPCRs in cancer development have been discussed in a series of papers. Uterine Corpus Endometrial Carcinoma (UCEC) isa malignanttumorofendometrium epithelial, whichis alsooneofthemostcommonfemalereproductivesystemtumors, …
The structure, function, and involvement of adhesion GPCRs in cancer development have been discussed in a series of papers. Uterine C …
Exploring and validating the prognostic value of pathomics signatures and genomics in patients with cutaneous melanoma based on bioinformatics and deep learning.
Li X, Yu X, Tian D, Liu Y, Li D. Li X, et al. Med Phys. 2023 Nov;50(11):7049-7059. doi: 10.1002/mp.16748. Epub 2023 Sep 18. Med Phys. 2023. PMID: 37722701
METHODS: Pathology full scans, clinical information, and genomics data for CM patients were downloaded from The Cancer Genome Atlas (TCGA) database. Exploratory data analysis (EDA) was used to visualize patient characteristics. ...There was a certain correlation between so …
METHODS: Pathology full scans, clinical information, and genomics data for CM patients were downloaded from The Cancer Genome Atlas ( …
Mutational and Transcriptional Characterization Establishes Prognostic Models for Resectable Lung Squamous Cell Carcinoma.
Liu Y, Duan J, Zhang F, Liu F, Luo X, Shi Y, Lei Y. Liu Y, et al. Cancer Manag Res. 2023 Feb 17;15:147-163. doi: 10.2147/CMAR.S384918. eCollection 2023. Cancer Manag Res. 2023. PMID: 36824152 Free PMC article.
BACKGROUND: The prognosis of non-small cell lung cancer (NSCLC) patients has been comprehensively studied. However, the prognosis of resectable (stage I-IIIA) lung squamous cell carcinoma (LUSC) has not been thoroughly investigated at genomic and transcriptional levels. ME …
BACKGROUND: The prognosis of non-small cell lung cancer (NSCLC) patients has been comprehensively studied. However, the prognosis of …
An investigation into the potential role of brain angiogenesis inhibitor protein 3 (BAI3) in the tumorigenesis of small-cell carcinoma: a review of the surrounding literature.
Thomas M, Snead D, Mitchell D. Thomas M, et al. J Recept Signal Transduct Res. 2017 Aug;37(4):325-334. doi: 10.1080/10799893.2017.1328441. Epub 2017 May 24. J Recept Signal Transduct Res. 2017. PMID: 28537194 Review.
Brain angiogenesis inhibitor protein 3 (BAI3) is from the adhesion group of seven-transmembrane spanning G protein-coupled receptors (GPCRs) and has been identified via gene expression profiling as being upregulated in small-cell lung cancer (SCLC) tumors. It has subsequen …
Brain angiogenesis inhibitor protein 3 (BAI3) is from the adhesion group of seven-transmembrane spanning G protein-coupled receptors (GPCRs) …
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.
Beliu G, Altrichter S, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW, Sauer M, Langenhan T. Beliu G, et al. Mol Cell. 2021 Mar 4;81(5):905-921.e5. doi: 10.1016/j.molcel.2020.12.042. Epub 2021 Jan 25. Mol Cell. 2021. PMID: 33497605 Free article.
Adhesion G protein-coupled receptors (aGPCRs)/family B2 GPCRs execute critical tasks during development and the operation of organs, and their genetic lesions are associated with human disorders, including cancers. Exceptional structural aGPCR features are the presence of …
Adhesion G protein-coupled receptors (aGPCRs)/family B2 GPCRs execute critical tasks during development and the operation of organs, and the …
Genomic analysis of an aggressive case with metastatic intrahepatic mucinous cholangiocarcinoma.
Masaki Y, Akutsu N, Adachi Y, Ishigami K, Iwata N, Endo T, Ishii Y, Sasaki Y, Nagayama M, Kimura Y, Nakase H. Masaki Y, et al. Clin J Gastroenterol. 2022 Aug;15(4):809-817. doi: 10.1007/s12328-022-01649-x. Epub 2022 Jun 14. Clin J Gastroenterol. 2022. PMID: 35699889
Next-generation sequencing revealed that somatic mutations in ADGRB3, TAF1L and EPHA3 may affect carcinogenesis, and those in TAF1, EPHA3, PIK3C2B, FN1, ERBB3, BRIP1, SYNE1 and TGFBR2 may affect metastasis. ...
Next-generation sequencing revealed that somatic mutations in ADGRB3, TAF1L and EPHA3 may affect carcinogenesis, and those in TAF1, E …
17 results