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57 results

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Did you mean and cancer (5,111,011 results)?
Tumour suppressive long non-coding RNA AFDN-DT inhibits gastric cancer invasion via transcriptional regulation.
Lai Y, Xu P, Wang J, Xu K, Wang L, Meng Y. Lai Y, et al. J Cell Mol Med. 2020 Mar;24(5):3157-3166. doi: 10.1111/jcmm.14988. Epub 2020 Jan 24. J Cell Mol Med. 2020. PMID: 31981317 Free PMC article.
Emerging evidence has revealed that dysregulation of lncRNA is associated with the initiation and progression of cancer. However, the function of these lncRNAs in cancer remains largely unexplored. Here, we reported that AFDN-DT, an lncRNA that is repressed i …
Emerging evidence has revealed that dysregulation of lncRNA is associated with the initiation and progression of cancer. However, the …
Afadin couples RAS GTPases to the polarity rheostat Scribble.
Goudreault M, Gagné V, Jo CH, Singh S, Killoran RC, Gingras AC, Smith MJ. Goudreault M, et al. Nat Commun. 2022 Aug 5;13(1):4562. doi: 10.1038/s41467-022-32335-8. Nat Commun. 2022. PMID: 35931706 Free PMC article.
The biological consequences of RAS complex with AFDN are unknown. We used proximity-based proteomics to generate an interaction map for two isoforms of AFDN, identifying the polarity protein SCRIB/Scribble as the top hit. ...Further, the dual RA domains of AFDN …
The biological consequences of RAS complex with AFDN are unknown. We used proximity-based proteomics to generate an interaction map f …
Etiology of oncogenic fusions in 5,190 childhood cancers and its clinical and therapeutic implication.
Liu Y, Klein J, Bajpai R, Dong L, Tran Q, Kolekar P, Smith JL, Ries RE, Huang BJ, Wang YC, Alonzo TA, Tian L, Mulder HL, Shaw TI, Ma J, Walsh MP, Song G, Westover T, Autry RJ, Gout AM, Wheeler DA, Wan S, Wu G, Yang JJ, Evans WE, Loh M, Easton J, Zhang J, Klco JM, Meshinchi S, Brown PA, Pruett-Miller SM, Ma X. Liu Y, et al. Nat Commun. 2023 Apr 5;14(1):1739. doi: 10.1038/s41467-023-37438-4. Nat Commun. 2023. PMID: 37019972 Free PMC article.
Oncogenic fusions formed through chromosomal rearrangements are hallmarks of childhood cancer that define cancer subtype, predict outcome, persist through treatment, and can be ideal therapeutic targets. ...We discover 4 oncogenic fusions, including RUNX1-RUNX1T1, T …
Oncogenic fusions formed through chromosomal rearrangements are hallmarks of childhood cancer that define cancer subtype, pred …
Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A.
Bill M, Mrózek K, Kohlschmidt J, Eisfeld AK, Walker CJ, Nicolet D, Papaioannou D, Blachly JS, Orwick S, Carroll AJ, Kolitz JE, Powell BL, Stone RM, de la Chapelle A, Byrd JC, Bloomfield CD. Bill M, et al. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26340-26346. doi: 10.1073/pnas.2014732117. Epub 2020 Oct 5. Proc Natl Acad Sci U S A. 2020. PMID: 33020282 Free PMC article.
Using targeted next-generation sequencing, we investigated the mutational status of 81 leukemia/cancer-associated genes in 96 patients with 11q23/KMT2A rearrangements with material for molecular studies available. ...KRAS mutations occurred more often in patients with t(6; …
Using targeted next-generation sequencing, we investigated the mutational status of 81 leukemia/cancer-associated genes in 96 patient …
Mitotic recombinatory evolution in acute leukemia.
Papenhausen P, Kelly CA, Zhang Z, Penton A. Papenhausen P, et al. Cancer Genet. 2023 Jun;274-275:33-40. doi: 10.1016/j.cancergen.2023.02.003. Epub 2023 Mar 11. Cancer Genet. 2023. PMID: 36966725
Relapse from an unrelated transplant donor created unique allele dosage ratios in the microarray of the AML patient with the t(6;11) KMT2A-AFDN fusion. An HMR-based evolution initiation site proximal to the 6q27 AFDN fusion gene is evident in the microarray of chrom …
Relapse from an unrelated transplant donor created unique allele dosage ratios in the microarray of the AML patient with the t(6;11) KMT2A- …
RAS GTPase signalling to alternative effector pathways.
Singh S, Smith MJ. Singh S, et al. Biochem Soc Trans. 2020 Oct 30;48(5):2241-2252. doi: 10.1042/BST20200506. Biochem Soc Trans. 2020. PMID: 33125484 Review.
RAS GTPases are fundamental regulators of development and drivers of an extraordinary number of human cancers. RAS oncoproteins constitutively signal through downstream effector proteins, triggering cancer initiation, progression and metastasis. ...We discuss here t …
RAS GTPases are fundamental regulators of development and drivers of an extraordinary number of human cancers. RAS oncoproteins const …
Defining bone fide effectors of RAS GTPases.
Smith MJ. Smith MJ. Bioessays. 2023 Sep;45(9):e2300088. doi: 10.1002/bies.202300088. Epub 2023 Jul 4. Bioessays. 2023. PMID: 37401638 Review.
RAS GTPases play essential roles in normal development and are direct drivers of human cancers. Three decades of study have failed to wholly characterize pathways stimulated by activated RAS, driven by engagement with 'effector' proteins that have RAS binding domains (RBDs …
RAS GTPases play essential roles in normal development and are direct drivers of human cancers. Three decades of study have failed to …
Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination.
Sewduth RN, Carai P, Ivanisevic T, Zhang M, Jang H, Lechat B, Van Haver D, Impens F, Nussinov R, Jones E, Sablina A. Sewduth RN, et al. Adv Sci (Weinh). 2023 Dec;10(36):e2303367. doi: 10.1002/advs.202303367. Epub 2023 Nov 9. Adv Sci (Weinh). 2023. PMID: 37946677 Free PMC article.
Specifically, WWP2-mediated RAP1 ubiquitination at lysine 31 switches the balance from the RAP1/ Talin 1 (TLN1) toward RAP1/ Afadin (AFDN) or RAP1/ RAS Interacting Protein 1 (RASIP1) complex formation, which is essential to suppress shear stress-induced reactive oxygen spe …
Specifically, WWP2-mediated RAP1 ubiquitination at lysine 31 switches the balance from the RAP1/ Talin 1 (TLN1) toward RAP1/ Afadin (AFDN …
Guidelines on Standard and Therapeutic Diets for Adults in Hospitals by the French Association of Nutritionist Dieticians (AFDN) and the French Speaking Society of Clinical Nutrition and Metabolism (SFNCM).
Vaillant MF, Alligier M, Baclet N, Capelle J, Dousseaux MP, Eyraud E, Fayemendy P, Flori N, Guex E, Hennequin V, Lavandier F, Martineau C, Morin MC, Mokaddem F, Parmentier I, Rossi-Pacini F, Soriano G, Verdier E, Zeanandin G, Quilliot D. Vaillant MF, et al. Nutrients. 2021 Jul 15;13(7):2434. doi: 10.3390/nu13072434. Nutrients. 2021. PMID: 34371943 Free PMC article. Review.
METHODS: These guidelines were developed using the Delphi method, as recommended by the HAS (French Health Authority), based on a formal consensus of experts and led by a group of practitioners and dieticians from the AFDN (French Association of Nutritionist Dieticians) an …
METHODS: These guidelines were developed using the Delphi method, as recommended by the HAS (French Health Authority), based on a formal con …
Detection of a Cryptic KMT2A/AFDN Gene Fusion [ins(6;11)(q27;q23q23)] in a Pediatric Patient with Newly Diagnosed Acute Myeloid Leukemia.
Berg HE, Greipp PT, Baughn LB, Falcon CP, Jackson CC, Peterson JF. Berg HE, et al. Lab Med. 2022 Jul 4;53(4):e95-e99. doi: 10.1093/labmed/lmab109. Lab Med. 2022. PMID: 34894139
A KMT2A break-apart FISH probe identified 2 intact copies of the KMT2A gene region and an extra 5'KMT2A signal in 85% of interphase nuclei. Subsequent FISH studies using a KMT2A/AFDN dual-color dual-fusion FISH probe revealed positive results for a single fusion in 82% of …
A KMT2A break-apart FISH probe identified 2 intact copies of the KMT2A gene region and an extra 5'KMT2A signal in 85% of interphase nuclei. …
57 results