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Year Number of Results
1996 1
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2007 1
2012 1
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2022 9
2023 13
2024 4

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49 results

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Page 1
DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA. Rooper LM, et al. Am J Surg Pathol. 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. Am J Surg Pathol. 2021. PMID: 34049316
This study aims to characterize a larger cohort of carcinomas with DEK-AFF2 fusions to assess whether they truly constitute a distinctive entity. ...Overall, the distinctive molecular, histologic, and clinical features of DEK-AFF2 carcinomas suggest they represent a …
This study aims to characterize a larger cohort of carcinomas with DEK-AFF2 fusions to assess whether they truly constitute a distinc …
DEK::AFF2 Fusion Carcinomas of Head and Neck.
Ruangritchankul K, Sandison A. Ruangritchankul K, et al. Adv Anat Pathol. 2023 Mar 1;30(2):86-94. doi: 10.1097/PAP.0000000000000376. Epub 2022 Oct 12. Adv Anat Pathol. 2023. PMID: 36221219 Review.
A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkeratinizing squamous cell carcinoma. ...This review aims to summarize the demographic, clinical, pathologic, immunophenotypic features, and patte …
A novel DEK::AFF2 fusion carcinoma was recently described in 29 patients who originally presented with non-viral-associated nonkerati …
DEK-AFF2 fusion-associated papillary squamous cell carcinoma of the sinonasal tract: clinicopathologic characterization of seven cases with deceptively bland morphology.
Kuo YJ, Lewis JS Jr, Zhai C, Chen YA, Chernock RD, Hsieh MS, Lan MY, Lee CK, Weinreb I, Hang JF. Kuo YJ, et al. Mod Pathol. 2021 Oct;34(10):1820-1830. doi: 10.1038/s41379-021-00846-2. Epub 2021 Jun 9. Mod Pathol. 2021. PMID: 34108636 Free article.
A novel DEK-AFF2 fusion has been recently identified in four cases of basaloid to nonkeratinizing squamous cell carcinoma (SCC) in the sinonasal tract and middle ear with high-grade morphology. ...The DEK gene rearrangement was confirmed by DEK break-apart fluorescence in …
A novel DEK-AFF2 fusion has been recently identified in four cases of basaloid to nonkeratinizing squamous cell carcinoma (SCC) in th …
Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK::AFF2 carcinoma of the sinonasal tract.
Kuo YJ, Lewis JS Jr, Truong T, Yeh YC, Chernock RD, Zhai C, Chen YA, Hongo T, Lee CK, Shi Q, Velez Torres JM, Geromes AB, Chu YH, Hsieh MS, Yamamoto H, Weinreb I, Hang JF. Kuo YJ, et al. Mod Pathol. 2022 Nov;35(11):1587-1595. doi: 10.1038/s41379-022-01117-4. Epub 2022 Jun 14. Mod Pathol. 2022. PMID: 35701667 Free article.
Sixteen of the 17 DEK::AFF2 carcinomas showed nuclear AFF2 expression in 30% of tumor cells, including one decalcified case that failed FISH and RT-PCR confirmation. ...All DEK FISH-negative sinonasal tumors were negative for nuclear AFF2 expression. The nucl …
Sixteen of the 17 DEK::AFF2 carcinomas showed nuclear AFF2 expression in 30% of tumor cells, including one decalcified case th …
Translocations and Gene Fusions in Sinonasal Malignancies.
Larkin R, Hermsen MA, London NR Jr. Larkin R, et al. Curr Oncol Rep. 2023 Apr;25(4):269-278. doi: 10.1007/s11912-023-01364-x. Epub 2023 Feb 8. Curr Oncol Rep. 2023. PMID: 36753024 Free PMC article. Review.
PURPOSE OF REVIEW: During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in cancer of the sinonasal tract. Here we review the downstream biologic effects, clinical characteristics, and pathologic features of …
PURPOSE OF REVIEW: During the past few years there has been an expansion in our understanding of gene fusions and translocations involved in …
[Sinonasal neoplasms: Update from the WHO 2022].
Agaimy A. Agaimy A. Pathologie (Heidelb). 2023 Jul;44(4):233-239. doi: 10.1007/s00292-023-01202-8. Epub 2023 Jun 7. Pathologie (Heidelb). 2023. PMID: 37286851 Review. German.
A highlight of the new classification is the inclusion of SWI/SNF (SMARCB1 or SMARCA4)-deficient carcinomas into a separate category. In addition, carcinomas with DEK::AFF2 fusions have been included as a provisional entity in the spectrum of nonkeratinizing squamous cell …
A highlight of the new classification is the inclusion of SWI/SNF (SMARCB1 or SMARCA4)-deficient carcinomas into a separate category. In add …
Simultaneous Screening of the FRAXA and FRAXE Loci for Rapid Detection of FMR1 CGG and/or AFF2 CCG Repeat Expansions by Triplet-Primed PCR.
Liu T, Wang FS, Cheah FSH, Gu Y, Shaw M, Law HY, Tay SKH, Lee CG, Nelson DL, Gecz J, Chong SS. Liu T, et al. J Mol Diagn. 2021 Aug;23(8):941-951. doi: 10.1016/j.jmoldx.2021.04.015. Epub 2021 Jun 7. J Mol Diagn. 2021. PMID: 34111553 Free article.
The duplex assay accurately identified expansions at the FMR1 and AFF2 trinucleotide repeat loci. On Sanger sequencing of the AFF2 CCG repeat, the single-nucleotide polymorphism variant rs868914124(C) that effectively adds two CCG repeats at the 5'-end, was enriched …
The duplex assay accurately identified expansions at the FMR1 and AFF2 trinucleotide repeat loci. On Sanger sequencing of the AFF2 …
First Report of Thoracic Carcinoma With DEK::AFF2 Rearrangement: A Case Report.
Savari O, Chang JC, Bishop JA, Sakthivel MK, Askin FB, Rekhtman N. Savari O, et al. J Thorac Oncol. 2022 Aug;17(8):1050-1053. doi: 10.1016/j.jtho.2022.05.009. Epub 2022 Jun 28. J Thorac Oncol. 2022. PMID: 35773081 Free PMC article.
DEK::AFF2 carcinomas of the head and neck region have been recently described and reported to have aggressive clinical behavior but exceptional sensitivity to immunotherapy. ...DEK (exon 7)::AFF2 (exon 9) fusion was identified by whole-transcriptome RNA sequencing. …
DEK::AFF2 carcinomas of the head and neck region have been recently described and reported to have aggressive clinical behavior but e …
The First Report of Cytology of DEK::AFF2 Fusion-Associated Papillary Squamous Cell Carcinoma on Fine-Needle Aspiration.
Li JJX, Ng JKM, Chan ABW. Li JJX, et al. Head Neck Pathol. 2023 Dec;17(4):1058-1063. doi: 10.1007/s12105-023-01594-2. Epub 2023 Nov 8. Head Neck Pathol. 2023. PMID: 37938508
DEK::AFF2 fusion-associated papillary squamous cell carcinoma is a recently characterized sinonasal malignancy defined by its unique translocation. DEK::AFF2 carcinomas may be deceptively monotonous and lack keratinization, resembling transitional epithelium. ...
DEK::AFF2 fusion-associated papillary squamous cell carcinoma is a recently characterized sinonasal malignancy defined by its unique …
Sinonasal Adenosquamous Carcinoma - Morphology and Genetic Drivers Including Low- and High-Risk Human Papillomavirus mRNA, DEK::AFF2 Fusion, and MAML2 Rearrangement.
Holliday D Jr, Mehrad M, Ely KA, Tong F, Wang X, Hang JF, Kuo YJ, Velez-Torres JM, Lott-Limbach A, Lewis JS Jr. Holliday D Jr, et al. Head Neck Pathol. 2023 Jun;17(2):487-497. doi: 10.1007/s12105-023-01538-w. Epub 2023 Feb 28. Head Neck Pathol. 2023. PMID: 36849671 Free PMC article.
They were tested for p16 expression by immunohistochemistry (70% cut-off), DEK::AFF2 fusion by fluorescence in situ hybridization (FISH) and AFF2 immunohistochemistry, MAML2 rearrangement by FISH, and low- and high-risk HPV by RNA ISH and reverse transcription PCR, …
They were tested for p16 expression by immunohistochemistry (70% cut-off), DEK::AFF2 fusion by fluorescence in situ hybridization (FI …
49 results