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Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.
Nat Immunol. 2011 Jun 19;12(8):770-7. doi: 10.1038/ni.2050.
Nat Immunol. 2011.
PMID: 21685908
Free PMC article.
Granzyme A activates another way to die.
Lieberman J.
Lieberman J.
Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x.
Immunol Rev. 2010.
PMID: 20536557
Free PMC article.
Review.
Item in Clipboard
Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.
Thiery J, Keefe D, Saffarian S, Martinvalet D, Walch M, Boucrot E, Kirchhausen T, Lieberman J.
Thiery J, et al.
Blood. 2010 Feb 25;115(8):1582-93. doi: 10.1182/blood-2009-10-246116. Epub 2009 Dec 28.
Blood. 2010.
PMID: 20038786
Free PMC article.
Item in Clipboard
NMR assignment and secondary structure of the STAS domain of Rv1739c, a putative sulfate transporter of Mycobacterium tuberculosis.
Sharma AK, Ye L, Zolotarev AS, Alper SL, Rigby AC.
Sharma AK, et al.
Biomol NMR Assign. 2009 Jun;3(1):99-102. doi: 10.1007/s12104-009-9150-z. Epub 2009 Mar 14.
Biomol NMR Assign. 2009.
PMID: 19636956
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Death by a thousand cuts: granzyme pathways of programmed cell death.
Chowdhury D, Lieberman J.
Chowdhury D, et al.
Annu Rev Immunol. 2008;26:389-420. doi: 10.1146/annurev.immunol.26.021607.090404.
Annu Rev Immunol. 2008.
PMID: 18304003
Free PMC article.
Review.
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Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity.
Nieland TJ, Shaw JT, Jaipuri FA, Duffner JL, Koehler AN, Banakos S, Zannis VI, Kirchhausen T, Krieger M.
Nieland TJ, et al.
Biochemistry. 2008 Jan 8;47(1):460-72. doi: 10.1021/bi701277x. Epub 2007 Dec 8.
Biochemistry. 2008.
PMID: 18067275
Free PMC article.
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