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2011 1
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Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-kappaB/ICAM1 axis.
Zhang Y, Zhang L, Zheng S, Li M, Xu C, Jia D, Qi Y, Hou T, Wang L, Wang B, Li A, Chen S, Si J, Zhuo W. Zhang Y, et al. Gut Microbes. 2022 Jan-Dec;14(1):2038852. doi: 10.1080/19490976.2022.2038852. Gut Microbes. 2022. PMID: 35220887 Free PMC article.
Mechanistically, we identified that F. nucleatum induced a new pattern recognition receptor ALPK1 to activate NF-kappaB pathway, resulting in the upregulation of ICAM1. Interestingly, the abundance of F. nucleatum in tumor tissues of CRC patients was positively associated …
Mechanistically, we identified that F. nucleatum induced a new pattern recognition receptor ALPK1 to activate NF-kappaB pathway, resu …
Gain-of-function mutations in ALPK1 cause an NF-kappaB-mediated autoinflammatory disease: functional assessment, clinical phenotyping and disease course of patients with ROSAH syndrome.
Kozycki CT, Kodati S, Huryn L, Wang H, Warner BM, Jani P, Hammoud D, Abu-Asab MS, Jittayasothorn Y, Mattapallil MJ, Tsai WL, Ullah E, Zhou P, Tian X, Soldatos A, Moutsopoulos N, Kao-Hsieh M, Heller T, Cowen EW, Lee CR, Toro C, Kalsi S, Khavandgar Z, Baer A, Beach M, Long Priel D, Nehrebecky M, Rosenzweig S, Romeo T, Deuitch N, Brenchley L, Pelayo E, Zein W, Sen N, Yang AH, Farley G, Sweetser DA, Briere L, Yang J, de Oliveira Poswar F, Schwartz IVD, Silva Alves T, Dusser P, Koné-Paut I, Touitou I, Titah SM, van Hagen PM, van Wijck RTA, van der Spek PJ, Yano H, Benneche A, Apalset EM, Jansson RW, Caspi RR, Kuhns DB, Gadina M, Takada H, Ida H, Nishikomori R, Verrecchia E, Sangiorgi E, Manna R, Brooks BP, Sobrin L, Hufnagel RB, Beck D, Shao F, Ombrello AK, Aksentijevich I, Kastner DL; Undiagnosed Diseases Network. Kozycki CT, et al. Ann Rheum Dis. 2022 Oct;81(10):1453-1464. doi: 10.1136/annrheumdis-2022-222629. Epub 2022 Jul 22. Ann Rheum Dis. 2022. PMID: 35868845 Free PMC article.
OBJECTIVES: To test the hypothesis that ROSAH (retinal dystrophy, optic nerve oedema, splenomegaly, anhidrosis and headache) syndrome, caused by dominant mutation in ALPK1, is an autoinflammatory disease. METHODS: This cohort study systematically evaluated 27 patients with …
OBJECTIVES: To test the hypothesis that ROSAH (retinal dystrophy, optic nerve oedema, splenomegaly, anhidrosis and headache) syndrome, cause …
ALPK1 mutants causing ROSAH syndrome or Spiradenoma are activated by human nucleotide sugars.
Snelling T, Saalfrank A, Wood NT, Cohen P. Snelling T, et al. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2313148120. doi: 10.1073/pnas.2313148120. Epub 2023 Dec 7. Proc Natl Acad Sci U S A. 2023. PMID: 38060563 Free PMC article.
In contrast, ALPK1 mutations cause two human diseases: the ALPK1[T237M] and ALPK1[Y254C] mutations underlie ROSAH syndrome (retinal dystrophy, optic nerve oedema, splenomegaly, anhidrosis, and migraine headache), while the ALPK1[V1092A] mutation accoun …
In contrast, ALPK1 mutations cause two human diseases: the ALPK1[T237M] and ALPK1[Y254C] mutations underlie ROSAH syndr …
The ALPK1/TIFA/NF-kappaB axis links a bacterial carcinogen to R-loop-induced replication stress.
Bauer M, Nascakova Z, Mihai AI, Cheng PF, Levesque MP, Lampart S, Hurwitz R, Pfannkuch L, Dobrovolna J, Jacobs M, Bartfeld S, Dohlman A, Shen X, Gall AA, Salama NR, Töpfer A, Weber A, Meyer TF, Janscak P, Müller A. Bauer M, et al. Nat Commun. 2020 Oct 9;11(1):5117. doi: 10.1038/s41467-020-18857-z. Nat Commun. 2020. PMID: 33037203 Free PMC article.
Here, we show that H. pylori-induced DNA damage occurs co-transcriptionally in S-phase cells that activate NF-kappaB signaling upon innate immune recognition of the lipopolysaccharide biosynthetic intermediate beta-ADP-heptose by the ALPK1/TIFA signaling pathway. DNA damag …
Here, we show that H. pylori-induced DNA damage occurs co-transcriptionally in S-phase cells that activate NF-kappaB signaling upon innate i …
Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation.
Martin-Gallausiaux C, Salesse L, Garcia-Weber D, Marinelli L, Beguet-Crespel F, Brochard V, Le Gléau C, Jamet A, Doré J, Blottière HM, Arrieumerlou C, Lapaque N. Martin-Gallausiaux C, et al. Gut Microbes. 2024 Jan-Dec;16(1):2295384. doi: 10.1080/19490976.2023.2295384. Epub 2023 Dec 21. Gut Microbes. 2024. PMID: 38126163 Free PMC article.
The anaerobic bacterium Fusobacterium nucleatum is significantly associated with human colorectal cancer (CRC) and is considered a significant contributor to the disease. ...Finally, it promoted the survival of CRC cells and reduced 5-fluorouracil chemosensitivity in vitro …
The anaerobic bacterium Fusobacterium nucleatum is significantly associated with human colorectal cancer (CRC) and is considered a si …
Systematic Review of the Role of Alpha-Protein Kinase 1 in Cancer and Cancer-Related Inflammatory Diseases.
Ko AM, Tu HP, Ko YC. Ko AM, et al. Cancers (Basel). 2022 Sep 9;14(18):4390. doi: 10.3390/cancers14184390. Cancers (Basel). 2022. PMID: 36139553 Free PMC article. Review.
METHODS: In this systematic review, we searched for and analyzed studies linking ALPK1 to cancer development and progression. RESULTS: Based on the current evidence obtained using human, animal, cellular, and tissue models, ALPK1 is located upstream and trigg …
METHODS: In this systematic review, we searched for and analyzed studies linking ALPK1 to cancer development and progression. …
Down-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers.
Liao HF, Lee HH, Chang YS, Lin CL, Liu TY, Chen YC, Yen JC, Lee YT, Lin CY, Wu SH, Ko YC, Chang JG. Liao HF, et al. Sci Rep. 2016 Jun 10;6:27350. doi: 10.1038/srep27350. Sci Rep. 2016. PMID: 27283888 Free PMC article.
In lung and colorectal cancer tissues, the ALPK1 RNA level of the normal part was higher than that of the tumor part using the RT-qPCR analysis. ...Taken together, these findings suggested that ALPK1 might play a vital role in cancer development and th …
In lung and colorectal cancer tissues, the ALPK1 RNA level of the normal part was higher than that of the tumor part using the …
ALPK1 Expression Is Associated with Lymph Node Metastasis and Tumor Growth in Oral Squamous Cell Carcinoma Patients.
Chen PK, Hua CH, Hsu HT, Kuo TM, Chung CM, Lee CP, Tsai MH, Yeh KT, Ko YC. Chen PK, et al. Am J Pathol. 2019 Jan;189(1):190-199. doi: 10.1016/j.ajpath.2018.09.003. Epub 2018 Oct 11. Am J Pathol. 2019. PMID: 30315765 Free article. Clinical Trial.
Oral squamous cell carcinoma (OSCC) is the most common malignant cancer, with high mortality rates in advanced stages. Recent studies have shown that the expression of ALPK1 mRNA and its inhibitory differentiation function are associated with cancer progressi …
Oral squamous cell carcinoma (OSCC) is the most common malignant cancer, with high mortality rates in advanced stages. Recent studies …
In vitro kinase assay reveals ADP-heptose-dependent ALPK1 autophosphorylation and altered kinase activity of disease-associated ALPK1 mutants.
García-Weber D, Dangeard AS, Teixeira V, Hauke M, Carreaux A, Josenhans C, Arrieumerlou C. García-Weber D, et al. Sci Rep. 2023 Apr 18;13(1):6278. doi: 10.1038/s41598-023-33459-7. Sci Rep. 2023. PMID: 37072480 Free PMC article.
ADPH binding to ALPK1 activates its kinase domain and triggers TIFA phosphorylation on threonine 9. ...We confirm that ALPK1 phosphorylates TIFA T9 and show that T2, T12 and T19 are also weakly phosphorylated by ALPK1. ...
ADPH binding to ALPK1 activates its kinase domain and triggers TIFA phosphorylation on threonine 9. ...We confirm that ALPK1 p …
Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis.
Lee CP, Ko AM, Nithiyanantham S, Lai CH, Ko YC. Lee CP, et al. J Mol Med (Berl). 2021 Sep;99(9):1323-1334. doi: 10.1007/s00109-021-02095-x. Epub 2021 Jun 7. J Mol Med (Berl). 2021. PMID: 34097087
More research for HAR1A activators or ALPK1 inhibitors is required to develop potential therapeutic agents for advanced oral cancer. ...ALPK1 inhibitors are potential kinase-targeted therapeutic agents for patients with advanced oral cancer....
More research for HAR1A activators or ALPK1 inhibitors is required to develop potential therapeutic agents for advanced oral cance …
30 results