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circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-beta signalling pathway-mediated activation of MMPs in pancreatic cancer.
Zhao Z, Yang W, Kong R, Zhang Y, Li L, Song Z, Chen H, Luo Y, Zhang T, Cheng C, Li G, Liu D, Geng X, Chen H, Wang Y, Pan S, Hu J, Sun B. Zhao Z, et al. Mol Cancer. 2023 Sep 9;22(1):152. doi: 10.1186/s12943-023-01847-2. Mol Cancer. 2023. PMID: 37689715 Free PMC article.
Moreover, although PDAC metastasis remains a leading cause of cancer-related deaths, the biological mechanism is poorly understood. ...CONCLUSIONS: Our study reveals that circEIF3I promotes pancreatic cancer progression. circEIF3I is a molecular scaffold that intera …
Moreover, although PDAC metastasis remains a leading cause of cancer-related deaths, the biological mechanism is poorly understood. . …
N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer.
Jiao J, Jiang L, Luo Y. Jiao J, et al. Recent Pat Anticancer Drug Discov. 2021;16(3):407-416. doi: 10.2174/1574892816666210615164645. Recent Pat Anticancer Drug Discov. 2021. PMID: 34137363
Several patents have reported the application of m6A mRNA modification in cancer diagnosis and treatment. Ovarian cancer is the leading cause of death among all gynecological cancers. It is urgent to identify new biomarkers for early diagnosis and prognosis o …
Several patents have reported the application of m6A mRNA modification in cancer diagnosis and treatment. Ovarian cancer is th …
Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes.
Pleasance E, Titmuss E, Williamson L, Kwan H, Culibrk L, Zhao EY, Dixon K, Fan K, Bowlby R, Jones MR, Shen Y, Grewal JK, Ashkani J, Wee K, Grisdale CJ, Thibodeau ML, Bozoky Z, Pearson H, Majounie E, Vira T, Shenwai R, Mungall KL, Chuah E, Davies A, Warren M, Reisle C, Bonakdar M, Taylor GA, Csizmok V, Chan SK, Zong Z, Bilobram S, Muhammadzadeh A, D'Souza D, Corbett RD, MacMillan D, Carreira M, Choo C, Bleile D, Sadeghi S, Zhang W, Wong T, Cheng D, Brown SD, Holt RA, Moore RA, Mungall AJ, Zhao Y, Nelson J, Fok A, Ma Y, Lee MKC, Lavoie JM, Mendis S, Karasinska JM, Deol B, Fisic A, Schaeffer DF, Yip S, Schrader K, Regier DA, Weymann D, Chia S, Gelmon K, Tinker A, Sun S, Lim H, Renouf DJ, Laskin J, Jones SJM, Marra MA. Pleasance E, et al. Nat Cancer. 2020 Apr;1(4):452-468. doi: 10.1038/s43018-020-0050-6. Epub 2020 Apr 13. Nat Cancer. 2020. PMID: 35121966
Recurrent noncoding events were found in regulatory region hotspots of genes including TERT, PLEKHS1, AP2A1 and ADGRG6. Mutation burden and immune signatures corresponded with overall survival and response to immunotherapy. Our data offer a rich resource for investigation …
Recurrent noncoding events were found in regulatory region hotspots of genes including TERT, PLEKHS1, AP2A1 and ADGRG6. Mutation burd …
Molecular cloning of novel transcripts of the adaptor-related protein complex 2 alpha 1 subunit (AP2A1) gene, using Next-Generation Sequencing.
Adamopoulos PG, Kontos CK, Diamantopoulos MA, Scorilas A. Adamopoulos PG, et al. Gene. 2018 Dec 15;678:55-64. doi: 10.1016/j.gene.2018.08.008. Epub 2018 Aug 4. Gene. 2018. PMID: 30081190
In brief, we subcultured fifty-five established human cell lines, originating from several distinct cancerous and normal tissues, extracted total RNA, and synthesized first-strand cDNA. ...Consequently, alterations in the levels of these potentially non-coding AP2A1 …
In brief, we subcultured fifty-five established human cell lines, originating from several distinct cancerous and normal tissues, ext …
Identification of Hub Genes in Pediatric Medulloblastoma by Multiple-Microarray Analysis.
Huang P, Guo YD, Zhang HW. Huang P, et al. J Mol Neurosci. 2020 Apr;70(4):522-531. doi: 10.1007/s12031-019-01451-4. Epub 2019 Dec 9. J Mol Neurosci. 2020. PMID: 31820345
Pediatric medulloblastoma is the leading cause of cancer-related death in children. However, few studies have reported gene expression profiles of pediatric medulloblastoma and the molecular mechanism underlying this disease is unclear. ...Protein-protein interaction (PPI) …
Pediatric medulloblastoma is the leading cause of cancer-related death in children. However, few studies have reported gene expressio …
AP-2α-Mediated Activation of E2F and EZH2 Drives Melanoma Metastasis.
White JR, Thompson DT, Koch KE, Kiriazov BS, Beck AC, van der Heide DM, Grimm BG, Kulak MV, Weigel RJ. White JR, et al. Cancer Res. 2021 Sep 1;81(17):4455-4470. doi: 10.1158/0008-5472.CAN-21-0772. Epub 2021 Jul 1. Cancer Res. 2021. PMID: 34210752 Free PMC article.
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Pils D, Tong D, Hager G, Obermayr E, Aust S, Heinze G, Kohl M, Schuster E, Wolf A, Sehouli J, Braicu I, Vergote I, Van Gorp T, Mahner S, Concin N, Speiser P, Zeillinger R. Pils D, et al. BMC Cancer. 2013 Apr 3;13:178. doi: 10.1186/1471-2407-13-178. BMC Cancer. 2013. PMID: 23551967 Free PMC article.
BACKGROUND: The immune system is a key player in fighting cancer. Thus, we sought to identify a molecular 'immune response signature' indicating the presence of epithelial ovarian cancer (EOC) and to combine this with a serum protein biomarker panel to increase the …
BACKGROUND: The immune system is a key player in fighting cancer. Thus, we sought to identify a molecular 'immune response signature' …
Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer - Proof of concept towards a systems pharmacology approach.
Saafan H, Foerster S, Parra-Guillen ZP, Hammer E, Michaelis M, Cinatl J Jr, Völker U, Fröhlich H, Kloft C, Ritter CA. Saafan H, et al. Eur J Pharm Sci. 2016 Oct 30;94:20-32. doi: 10.1016/j.ejps.2016.04.025. Epub 2016 Apr 23. Eur J Pharm Sci. 2016. PMID: 27112992
Drug treatment of epidermal growth factor receptor (EGFR) positive non-small cell lung cancer has improved substantially by targeting activating mutations within the receptor tyrosine kinase domain. ...Affinity purification coupled with high resolution mass spectrometry wa …
Drug treatment of epidermal growth factor receptor (EGFR) positive non-small cell lung cancer has improved substantially by targeting …
Genomic Fabrics of the Excretory System's Functional Pathways Remodeled in Clear Cell Renal Cell Carcinoma.
Iacobas DA, Obiomon EA, Iacobas S. Iacobas DA, et al. Curr Issues Mol Biol. 2023 Nov 24;45(12):9471-9499. doi: 10.3390/cimb45120594. Curr Issues Mol Biol. 2023. PMID: 38132440 Free PMC article.
The present study confirms the conclusion of our previously published articles on prostate and kidney cancers that even equally graded cancer nodules from the same tumor have different transcriptomic topologies. Therefore, the personalization of anti-cancer t …
The present study confirms the conclusion of our previously published articles on prostate and kidney cancers that even equally grade …
Interaction of Shc with adaptor protein adaptins.
Okabayashi Y, Sugimoto Y, Totty NF, Hsuan J, Kido Y, Sakaguchi K, Gout I, Waterfield MD, Kasuga M. Okabayashi Y, et al. J Biol Chem. 1996 Mar 1;271(9):5265-9. doi: 10.1074/jbc.271.9.5265. J Biol Chem. 1996. PMID: 8617812 Free article.
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