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Therapeutic targets for endometriosis: Genome-wide Mendelian randomization and colocalization analyses.
Zeng P, Lu L, Zhang H, Li Y, Tan S, Yu T, Zhou H. Zeng P, et al. Gene. 2024 Jan 30;893:147970. doi: 10.1016/j.gene.2023.147970. Epub 2023 Nov 4. Gene. 2024. PMID: 37931855
On the other hand, progestin and adipoQ receptor family member 8 (PAQR8), adaptor related protein complex 3 subunit mu 1 (AP3M1), surfeit 6 (SURF6), TUB bipartite transcription factor (TUB), and DNA polymerase delta interacting protein 2 (POLDIP2) were found to have invers …
On the other hand, progestin and adipoQ receptor family member 8 (PAQR8), adaptor related protein complex 3 subunit mu 1 (AP3M1), sur …
Zhachong Shisanwei Pill resists ischemic stroke by lysosome pathway based on proteomics and bioinformatics.
Song Q, Bi L, Jiao J, Shang J, Li Q, Shabuerjiang L, Bai M, Liu X. Song Q, et al. J Ethnopharmacol. 2023 Jan 30;301:115766. doi: 10.1016/j.jep.2022.115766. Epub 2022 Sep 29. J Ethnopharmacol. 2023. PMID: 36183948
Proteomics results showed that the anti-IS action of ZSP was mainly through lysosome pathway. LAMP2, AP3M1, and SCARB2 were the differentially changed proteins in this pathway. ...CONCLUSION: This study confirms that ZSP regulates the lysosomal pathway, which may protect I …
Proteomics results showed that the anti-IS action of ZSP was mainly through lysosome pathway. LAMP2, AP3M1, and SCARB2 were the diffe …
Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer.
Gonçalves E, Fragoulis A, Garcia-Alonso L, Cramer T, Saez-Rodriguez J, Beltrao P. Gonçalves E, et al. Cell Syst. 2017 Oct 25;5(4):386-398.e4. doi: 10.1016/j.cels.2017.08.013. Epub 2017 Oct 11. Cell Syst. 2017. PMID: 29032074 Free PMC article.
We identified 48 such rate-limiting interactions and experimentally confirmed our predictions on the interactions of AP3B1 with AP3M1 and GTF2E2 with GTF2E1. This study highlights the importance of post-transcriptional mechanisms in cancer that allow cells to cope with the …
We identified 48 such rate-limiting interactions and experimentally confirmed our predictions on the interactions of AP3B1 with AP3M1 …
Association analysis between schizophrenia and the AP-3 complex genes.
Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, Taya S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H. Hashimoto R, et al. Neurosci Res. 2009 Sep;65(1):113-5. doi: 10.1016/j.neures.2009.05.008. Epub 2009 May 27. Neurosci Res. 2009. PMID: 19481122
As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia ( …
As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 compl …
Downregulation of genes encoding for subunits of adaptor complex-3 in cervical carcinomas.
Petrenko AA, Pavlova LS, Karseladze AI, Kisseljov FL, Kisseljova NP. Petrenko AA, et al. Biochemistry (Mosc). 2006 Oct;71(10):1153-60. doi: 10.1134/s0006297906100130. Biochemistry (Mosc). 2006. PMID: 17125464
Using RT-PCR we demonstrated more than twofold decrease in the levels of mRNA of AP3D1, AP3B1, AP3M1, and AP3S1 in 32, 28, 23, and 26% tumors in comparison with normal tissues of uterine cervix, respectively. ...
Using RT-PCR we demonstrated more than twofold decrease in the levels of mRNA of AP3D1, AP3B1, AP3M1, and AP3S1 in 32, 28, 23, and 26 …