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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 2
2001 1
2002 2
2004 3
2006 1
2007 1
2009 2
2010 2
2011 1
2012 2
2013 4
2014 2
2015 3
2016 1
2017 3
2018 3
2019 2
2020 4
2021 7
2022 7
2023 4
2024 0

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48 results

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Page 1
Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease.
Morton SU, Shimamura A, Newburger PE, Opotowsky AR, Quiat D, Pereira AC, Jin SC, Gurvitz M, Brueckner M, Chung WK, Shen Y, Bernstein D, Gelb BD, Giardini A, Goldmuntz E, Kim RW, Lifton RP, Porter GA Jr, Srivastava D, Tristani-Firouzi M, Newburger JW, Seidman JG, Seidman CE. Morton SU, et al. JAMA Cardiol. 2021 Apr 1;6(4):457-462. doi: 10.1001/jamacardio.2020.4947. JAMA Cardiol. 2021. PMID: 33084842 Free PMC article.
EXPOSURES: Presence of rare (allele frequency, <1 10-5) loss-of-function (LoF) variants in cancer risk genes. MAIN OUTCOMES AND MEASURES: Frequency of LoF variants in cancer risk genes (defined in the Catalogue of Somatic Mutations in Cancer-Cancer …
EXPOSURES: Presence of rare (allele frequency, <1 10-5) loss-of-function (LoF) variants in cancer risk genes. MAIN OUTCOMES AND ME …
miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis.
Ge W, Goga A, He Y, Silva PN, Hirt CK, Herrmanns K, Guccini I, Godbersen S, Schwank G, Stoffel M. Ge W, et al. Gastroenterology. 2022 Jan;162(1):269-284. doi: 10.1053/j.gastro.2021.09.029. Epub 2021 Sep 20. Gastroenterology. 2022. PMID: 34547282 Free article.
Genetic ablation of mir-802 cooperates with Kras(G12D) by promoting ADM formation. miR-802 deficiency results in de-repression of the miR-802 targets Arhgef12, RhoA, and Sdc4, activation of RhoA, and induction of the downstream RhoA effectors ROCK1, LIMK1, COFILIN1, and EZ …
Genetic ablation of mir-802 cooperates with Kras(G12D) by promoting ADM formation. miR-802 deficiency results in de-repression of the miR-80 …
Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity.
Yang Y, Wang S, Cai J, Liang J, Zhang Y, Xie Y, Luo F, Tang J, Gao Y, Shen S, Feng H, Li Y. Yang Y, et al. Cell Oncol (Dordr). 2023 Feb;46(1):133-143. doi: 10.1007/s13402-022-00739-9. Epub 2022 Dec 15. Cell Oncol (Dordr). 2023. PMID: 36520365
Animal xenograft models were used to investigate antitumor effects after ARHGEF12 knockdown or treatment with the ARHGEF12 inhibitor Y16 in vivo. ...CONCLUSION: Our findings provide new insight into the mechanism by which ARHGEF12 regulates neuroblastoma tumo …
Animal xenograft models were used to investigate antitumor effects after ARHGEF12 knockdown or treatment with the ARHGEF12 inh …
KMT2A-ARHGEF12, a therapy related fusion with poor prognosis.
Assaf N, Liévin R, Merabet F, Raggueneau V, Osman J, Kim R, Garnache F, D'Angiò M, Larghero P, Meyer C, Marschalek R, Rousselot P, Terré C. Assaf N, et al. Mol Biol Rep. 2021 Oct;48(10):7021-7027. doi: 10.1007/s11033-021-06621-5. Epub 2021 Aug 12. Mol Biol Rep. 2021. PMID: 34383244 Review.
The review of the few cases of KMT2A-ARHGEF12 reveals the tendency of this deletion to occur in therapy related hematologic neoplasm and confer unfavorable prognosis. CONCLUSION: This review sheds light into the rare KMT2A-ARHGEF12 fusion in leukemia. Reporting rare …
The review of the few cases of KMT2A-ARHGEF12 reveals the tendency of this deletion to occur in therapy related hematologic neoplasm …
ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.
Xie Y, Gao L, Xu C, Chu L, Gao L, Wu R, Liu Y, Liu T, Sun XJ, Ren R, Tang J, Zheng Y, Zhou Y, Shen S. Xie Y, et al. Haematologica. 2020 Apr;105(4):925-936. doi: 10.3324/haematol.2018.210286. Epub 2019 Aug 29. Haematologica. 2020. PMID: 31467124 Free PMC article.
We further demonstrated in zebrafish by morpholino-mediated knockdown and CRISPR/Cas9-mediated knockout of arhgef12 that its reduction resulted in erythropoiesis defects. The p38 kinase pathway was affected by the ARHGEF12-RhoA signaling in K562 cells, and consisten …
We further demonstrated in zebrafish by morpholino-mediated knockdown and CRISPR/Cas9-mediated knockout of arhgef12 that its reductio …
Bioinformatics analysis and identification of upregulated tumor suppressor genes associated with suppressing colon cancer progression by curcumin treatment.
Wu D, Fu Z, Liu W, Zhao Y, Li W, Liu Q, Liang Y. Wu D, et al. Front Pharmacol. 2023 Sep 5;14:1218046. doi: 10.3389/fphar.2023.1218046. eCollection 2023. Front Pharmacol. 2023. PMID: 37731740 Free PMC article.
ARHGEF12 is a newly identified TSG and a potential therapeutic target for colon cancer. Furthermore, molecular docking was performed to predict the binding sites of CUR and ARHGEF12, suggesting that CUR can prevent colon cancer cell invasion and metast …
ARHGEF12 is a newly identified TSG and a potential therapeutic target for colon cancer. Furthermore, molecular docking was per …
The putative oncogenic role of WDTC1 in colorectal cancer.
Wang X, Cai Q, Ping J, Diaz-Zabala H, Xia Y, Guo X. Wang X, et al. Carcinogenesis. 2022 Jun 27;43(6):594-600. doi: 10.1093/carcin/bgac027. Carcinogenesis. 2022. PMID: 35238908 Free PMC article.
The ingenuity pathways analysis suggested that the most significant enrichments associated with cancer function and upstream regulator ATM/ATR were observed for these commonly observed genes. We further verified differential gene expression of eight cancer-related g …
The ingenuity pathways analysis suggested that the most significant enrichments associated with cancer function and upstream regulato …
Identification of KMT2A-ARHGEF12 fusion in a child with a high-grade B-cell lymphoma.
Schafernak KT, Williams JA, Clyde BI, Marcus C, Decker B, Toydemir RM. Schafernak KT, et al. Cancer Genet. 2021 Nov;258-259:23-26. doi: 10.1016/j.cancergen.2021.06.006. Epub 2021 Jun 27. Cancer Genet. 2021. PMID: 34237703
There is a diverse recombinome associated with KMT2A involving at least 135 partner genes, with more being discovered due to advances in molecular genetic diagnostics. KMT2A-ARHGEF12 fusion has only rarely been reported, in five cases of acute leukemia and a single case of …
There is a diverse recombinome associated with KMT2A involving at least 135 partner genes, with more being discovered due to advances in mol …
48 results